Clinical profile of brucellosis from a tertiary care center in southern India

Sathyanarayanan, Vishwanath; Razak, Abdul; Saravu, Kavitha; Ananthakrishna, Shastry Barkur; Prabhu, Mukhyaprana; Vandana, KE

doi:10.1016/s1995-7645(11)60111-9

Cited by 28 publications

(33 citation statements)

References 26 publications

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“…34.8%) have been reported in other studies. (11,13,18,21,22) In the present study, 20 patients had a negative SAT for brucellosis, according to serological diagnostic criteria (titre ≥ 1:160), during the fi rst admission. However, these patients were diagnosed with brucellosis using culture results or increasing titres.…”

Section: Discussionmentioning

confidence: 68%

“…The complaints and physical examination fi ndings at admission in other studies of patients diagnosed with brucellosis were similar to those observed in the present study. (10)(11)(12)(13)(14)(15)(16)(17)(18) The most frequent complaints among subacute and chronic brucellosis patients were back and joint pain. We believe that spondylodiscitis should be investigated in patients with back pain.…”

Section: Discussionmentioning

confidence: 99%

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Brucellosis: a retrospective evaluation of 164 cases

Kazak

Akalın

Yılmaz

et al. 2016

smedj

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INTRODUCTIONBrucellosis is a public health problem that is prevalent in several developing countries. METHODS The clinical and laboratory characteristics of 164 cases of brucellosis in Bursa, Turkey, were retrospectively evaluated. RESULTSThe ages of the 164 patients ranged from 15-85 years. All of the patients underwent the Rose Bengal test and 163 (99.4%) patients tested positive. 122 (74.4%) patients were diagnosed with acute brucellosis, 31 (18.9%) with subacute brucellosis and 11 (6.7%) with chronic brucellosis. Focal involvement was found in 101 (61.6%) patients. Although patients with focal involvement had a higher white blood cell count (p = 0.002), those without focal involvement had higher aspartate transaminase and alanine transaminase values, and lower platelet values (p = 0.005, 0.007 and 0.039, respectively). Spondylodiscitis was observed on imaging in 58 (66.7%) of the 87 patients who presented with back pain. Among the 118 patients who were examined within the fi rst month of treatment, 79 (66.9%) responded to treatment. The relapse rate was 11.6% among all 164 patients.CONCLUSION Brucellosis should be considered as a differential diagnosis among patients who present with fever, and joint or back pain. Focal involvement should be investigated in the presence of leucocytosis, and subacute or chronic forms of brucellosis. To identify cases of spondylodiscitis, radiography should be performed in patients who present with back pain.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Brucellosis: a retrospective evaluation of 164 cases

Kazak

Akalın

Yılmaz

et al. 2016

smedj

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“…Humans are infected via the consumption of raw meat and non-pasteurised diary products that have been contaminated with brucellosis 5. Our patient had a history of consuming non-pasteurised milk and other dairy products.…”

Section: Discussionmentioning

confidence: 95%

“…Uveitis frequently occurs when the disease involves the eye. The clinical diagnosis of brucellosis requires isolation of the bacteria with a blood or tissue culture or the presence of specific antibodies via an agglutination test, complement fixation test, radioimmunoassay, or ELISA 5. Although uveitis is idiopathic with a prevalence of 30–40%, it may be comorbid with some rheumatological and infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

Bilateral sacroiliitis and uveitis comorbidity: brucellosis? Ankylosing spondylitis?

Akyol

Aslan²,

Özgen

et al. 2015

BMJ Case Reports

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We present a rare case of a comorbidity of sacroiliitis and brucellosis infection. A 28-year-old woman received irregular medication due to ongoing backache and hip pain for 5 years. The patient presented to our hospital for evaluation of visual loss and was diagnosed with uveitis. Sacroiliac MRI was performed to investigate the inflammatory backache and hip pain, and the aetiology of the uveitis, revealing the presence of sacroiliitis. The patient's blood test results were as follows: positive brucellosis Rose Bengal test and positive tube agglutination test with a titre of 1/640. The patient was treated with doxycycline and rifampicin for 8 weeks for the brucellosis infection, and with acemetacin for the ankylosing spondylitis. The patient's back and hip pain decreased significantly 8 weeks later; however, the uveitis was not controlled by the treatment. Therefore, anti-tumour necrosis factor (infliximab) treatment was started.

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“…Brucella spp. is classified as a Class B Bioterrorist agent, posing a major public health problem in many developing and developed countries [4]. …”

Section: Introductionmentioning

confidence: 99%

Classical Presentation of Acute Pyelonephritis in a Case of Brucellosis

Al-Sahali

Sultan²,

Dhar

2016

Case Rep Nephrol Dial

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Although Brucella species is known to affect almost all organs in humans, renal involvement presenting as acute pyelonephritis remains a rare entity in brucellosis. We report the case of a female patient who presented with symptoms of fever with chills, right loin pain and dysuria in the emergency room. Blood cultures drawn at the time of admission grew Brucella spp., but no organisms were isolated from urine culture although urinalysis data was indicative of urinary tract infection. Empiric therapy with piperacillin/tazobactam plus gentamicin relieved her symptoms. However, the treatment was switched to doxycycline plus rifampicin once the blood culture result was obtained.

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Clinical profile of brucellosis from a tertiary care center in southern India

Abstract: In countries like India, where brucellosis and tuberculosis are endemic; rapid, sensitive and highly specific diagnostic methods are required to make early diagnosis and prevent resistance as there is an overlap in therapy.

Cited by 28 publications

References 26 publications

Brucellosis: a retrospective evaluation of 164 cases

Brucellosis: a retrospective evaluation of 164 cases

Bilateral sacroiliitis and uveitis comorbidity: brucellosis? Ankylosing spondylitis?

Classical Presentation of Acute Pyelonephritis in a Case of Brucellosis

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