Clinical profile of childhood vitiligo at a tertiary hospital in North Kerala

Kambil, Srirath Madappally

doi:10.18203/issn.2455-4529.intjresdermatol20181399

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…17 We encountered maximum cases between the age group of 6 to 10 years with 40%, whereas it was 45.5% in the study by Afsar FS et al 15 In our study, a family history of vitiligo was seen in 14% of cases. It is similar to Indian studies by Hafi et al 18 12%, Murugaiyan et al 19 12.5%, PK Sheth et al 20 14% and SM Kambil et al 21 15%, but much lesser than the findings of Nicolaidou et al 22 35% respectively. Positive familial incidence indicate that genetic influences have a role in the pathogenesis of vitiligo.…”

Section: Discussionsupporting

confidence: 89%

Evaluation of thyroid abnormalities in childhood vitiligo from a tertiary care centre: A case-control study

Salecha¹,

Sridevi³

et al. 2023

PJMS

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Vitiligo is an usual acquired pigmentary disorder of the skin characterized by well-circumscribed depigmented macules and patches. Though the association between vitiligo and thyroid disorders has been suggested, only a few studies from India and overseas have paid attention to describe the association between vitiligo and thyroid abnormalities, particularly in children. Hence, this study was taken up for evaluating thyroid disease in childhood vitiligo compared to controls in a tertiary care centre.This was a hospital-based case-control study conducted at a tertiary teaching hospital over 18 months which included 50 new patients of vitiligo and 50 age and sex-matched controls. Blood samples were garnered from cases and controls to access the levels of free triiodothyronine (fT3), free thyroxine (fT4), Thyroid-stimulating hormone ( TSH), anti-thyroid peroxidase (anti-TPO), and anti-thyroglobulin (anti –Tg).In our study, females outnumbered males in both groups. The frequencies of thyroid function and thyroid autoantibody abnormalities among vitiligo patients and control were 32% and 6%, respectively. The difference between case and controls for thyroid function abnormality was significant with a p-value of 0.001.Our study found a significant association betwixt thyroid disease and childhood vitiligo. Thus, evaluating vitiligo patients for thyroid abnormalities help to detect thyroid diseases or determine the possibility of eventual onset.

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Section: Discussionsupporting

confidence: 89%

Evaluation of thyroid abnormalities in childhood vitiligo from a tertiary care centre: A case-control study

Salecha¹,

Sridevi³

et al. 2023

PJMS

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Clinico epidemiological study of vitiligo in children

Ali¹,

Basha²

2020

IJCED

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Vitiligo is a common acquired pigmentary disorder characterized by well defined hypopigmented or depigmented macules due to absence or decrease in melanocytes. To study the clinico epidemiological pattern of vitiligo in children. A group of 50 consecutive children attending out patient in the department of DVL at Shadan Institute of Medical Sciences will be included. All the patients meeting the inclusion criteria were taken into the study. A designed, coded proforma was used for recording all the findings. Almost half of the children taken for study belongs to age group of 9-11 years. Majority of the study population were females. The most common pattern of vitiligo was vitiligo vulgaris. Common site of involvement was lower limbs. The most common associated feature was leukotrichia. The most common associated condition was photosensitivity. Family history was positive in only 4% of cases. Most of them were in the active stage of disease. The female predominance was high in prevalence of vitiligo in children and an earlier age of onset seen among children with family history of vitiligo or autoimmune disorders. Vitiligo vulgaris is the most common presentation, and lower limbs being the most common site of involvement in children

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Childhood onset vitiligo − clinical profile and impact on quality of life of family members

Augustine,

John

2023

Pigment International

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Background: Vitiligo, a chronic disease, is distressing for patients and family. There are only a few studies on childhood onset vitiligo that describe its prognosis. Aim: To study the clinical and epidemiologic features of childhood onset vitiligo and to assess its impact on quality of life (QoL) of family members. Methods: A cross-sectional study was carried out on patients with vitiligo, with onset before 12 years of age. Clinicoepidemiologic profile was recorded. QoL of family members was assessed using family dermatology life quality index (FDLQI). Results: Fifty-four patients with age ranging from 1.2 to 41 years were included. Mean age of onset was 6.68 ± 3.43 years. Generalized vitiligo was most common (33.33%), followed by segmental (31.48%), acrofacial (24.07%), mucosal (7.40%), universal (1.85%), and focal (1.85%) types. About 42% had mucosal involvement, oral mucosa in 27.78%, and genital mucosa in 14.81%. Leukotrichia was significantly more common in segmental vitiligo (SV) than nonsegmental vitiligo (NSV) (P = 0.000046). Of the 9 adult NSV patients, progressive disease was reported in 6 with 10 years duration and 2 with 20 years duration. Mean FDLQI was 7.02 ± 3.64; emotional distress having maximum score (1.09). There was no significant association between total FDLQI and age (P = 0.69), gender (P = 0.528), clinical type (P = 0.874), vitiligo disease activity (VIDA) score (P = 0.105), or site of involvement (P = 0.07). Conclusion: NSV can be progressive for many years; a fact to be kept in mind while planning management of childhood onset vitiligo. QoL of family is affected regardless of the clinicoepidemiologic profile.

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Clinical profile of childhood vitiligo at a tertiary hospital in North Kerala

Cited by 3 publications

References 6 publications

Evaluation of thyroid abnormalities in childhood vitiligo from a tertiary care centre: A case-control study

Evaluation of thyroid abnormalities in childhood vitiligo from a tertiary care centre: A case-control study

Clinico epidemiological study of vitiligo in children

Childhood onset vitiligo − clinical profile and impact on quality of life of family members

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