Clinical profile of children under 5 years of age with rotavirus diarrhoea in a hospital setting in Kisangani, DRC, after the introduction of the rotavirus vaccine, a cross-sectional study

Gbebangi-Manzemu, Didier; Kampunzu, Véronique Muyobela; Vanzwa, Hortense Malikidogo; Mumbere, Mupenzi; Bukaka, Gaspard Mande; Likele, Bibi Batoko; Kasai, Emmanuel Tebandite; Mukinayi, Benoit Mbiya; Tonen-Wolyec, Serge; Dauly, Nestor Ngbonda; Opara, Jean Pierre Alworong’a

doi:10.1186/s12887-023-04022-0

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…Approximately 10 ml of fecal material was collected in a 20 ml Falcon tube for rotavirus and adenovirus diagnosis using BYOSYNEX adenovirus/rotavirus BSS (Biosynex SA, Illkirch-Graffenstaden, France), a rapid in vitro diagnostic immunochromatographic test. As previously reported, only 50 μl of fecal material was used with the BYOSYNEX adenovirus/rotavirus BSS [ 15 ]. The remaining fecal samples were stored at -20°C for subsequent molecular analysis.…”

Section: Methodsmentioning

confidence: 99%

Rotavirus and adenovirus infections in children with acute gastroenteritis after introducing the Rotasiil® vaccine in Kisangani, Democratic Republic of the Congo

Manzemu,

Opara,

Kasai

et al. 2024

PLoS ONE

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Background Although rotavirus vaccination has reduced the global burden of the virus, morbidity and mortality from rotavirus infection remain high in Sub-Saharan Africa. This study aimed to determine the prevalence of rotavirus and adenovirus infections in children under five years with acute gastroenteritis and to identify factors associated with rotavirus infection after the introduction of the Rotasiil® vaccine in 2019 in Kisangani, Democratic Republic of the Congo (DRC). Methods This study consisted of a cross-sectional hospital-based survey conducted from May 2022 to April 2023 in four health facilities in Kisangani, using a fecal-based test (rapid antigenic immuno-chromatographic diagnostic test, BYOSYNEX adenovirus/rotavirus BSS, Biosynex SA, Illkirch-Graffenstaden, France) of rotavirus and adenovirus infections among children under five years of age with acute gastroenteritis. Results A total of 320 children under five years of age with acute gastroenteritis were included. The prevalence of rotavirus infection was 34.4%, that of adenovirus was 6.3%, and that of both rotavirus and adenovirus coinfection was 1.3%. The prevalence of rotavirus was significantly higher in unvaccinated children than in vaccinated children (55.4% versus 23.1%; P < 0.001). This difference was observed only in children who received all three vaccine doses. Multivariate logistic regression analysis shows that the rate of rotavirus infection was significantly reduced in vaccinated children (adjusted OR: 0.31 [95% confidence intervals (CI): 0.19–0.56]; P < 0.001) and those whose mothers had an average (adjusted OR: 0.51 [95% CI: 0.25–0.91]; P = 0.018) or high level (adjusted OR: 0.34 [95% CI: 0.20–0.64]; P < 0.001) of knowledge about the rotavirus vaccine. Conclusions The prevalence of rotavirus infection remains high in Kisangani despite vaccination. However, the prevalence of adenovirus infections was low in our series. Complete vaccination with three doses and mothers’ average and high level of knowledge about the rotavirus vaccine significantly reduces the rate of rotavirus infection. It is, therefore, essential to strengthen the mothers’ health education, continue with the Rotasiil® vaccine, and ensure epidemiological surveillance of rotavirus infection.

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Section: Methodsmentioning

confidence: 99%

Rotavirus and adenovirus infections in children with acute gastroenteritis after introducing the Rotasiil® vaccine in Kisangani, Democratic Republic of the Congo

Manzemu,

Opara,

Kasai

et al. 2024

PLoS ONE

Self Cite

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“…These measures, while primarily aimed at curbing the spread of SARS-CoV-2, also affected the transmission dynamics of other infectious agents, including rotavirus. [4][5][6][7] Limited studies have shown that the measures taken to control COVID-19 led to significant reductions in the incidence of rotavirus and other enteric viral infections [8][9][10][11][12][13][14][15] , highlighting the collateral benefits of such public health interventions. However, comprehensive data on changes in the frequency of rotavirus infections before and during the COVID-19 pandemic are still lacking.…”

Section: Introductionmentioning

confidence: 99%

Effect of the COVID-19 Pandemic on Rotavirus Infection Frequency in Children

Nas,

Gözüküçük

2024

Journal of Health Sciences and Medicine

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Aims: During the COVID-19 pandemic, measures such as the wearing of masks, social distancing, enhanced hygiene practices, closures of workplaces and schools, and lockdowns influenced the spread of various infectious diseases. This study aimed to compare the frequency of rotavirus infections during the pandemic to that of the pre-pandemic period. Methods: This retrospective study included 2912 patients diagnosed with acute gastroenteritis who were admitted to the Pediatric Health and Diseases Department of Hisar Intercontinental Hospital between January 2018 and August 2022. For the diagnosis of rotavirus infection, the Rota-Adeno Ag Rapid Test-Cassette was applied to stool samples as an immunochromatographic method. Patients were divided into two groups based on their hospital admission dates: before the COVID-19 pandemic (1 January 2018 to 10 March 2020) and during the COVID-19 pandemic (11 March 2020 to 30 August 2022). Results: The prevalence of rotavirus infection in the entire population was 9.5% (n=277). The rate of cases of rotavirus infection was higher among patients during the COVID-19 pandemic compared to the group of patients before the COVID-19 pandemic (10.9% vs. 8.7%, p=0.050). A sharp decline in the frequency of rotavirus infection was observed at the beginning of the COVID-19 pandemic compared to the pre-COVID-19 pandemic period, followed by a sharp increase. In 2022, the frequency of rotavirus infections exceeded the pre-COVID-19 pandemic levels. Conclusion: The provision of the rotavirus vaccine for free by health authorities, especially for at-risk infants, together with adherence to hand washing, hygiene, and sanitation rules can significantly reduce the frequency of rotavirus infections during both pandemic and non-pandemic periods.

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Overview of the Trending Enteric Viruses and Their Pathogenesis in Intestinal Epithelial Cell Infection

Chio,

Chien,

Chan

et al. 2024

Biomedicines

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Enteric virus infection is a major public health issue worldwide. Enteric viruses have become epidemic infectious diseases in several countries. Enteric viruses primarily infect the gastrointestinal tract and complete their life cycle in intestinal epithelial cells. These viruses are transmitted via the fecal–oral route through contaminated food, water, or person to person and cause similar common symptoms, including vomiting, abdominal pain, and diarrhea. Diarrheal disease is the third leading cause of death in children under five years of age, accounting for approximately 1.7 billion cases and 443,832 deaths annually in this age group. Additionally, some enteric viruses can invade other tissues, leading to severe conditions and even death. The pathogenic mechanisms of enteric viruses are also unclear. In this review, we organized the research on trending enteric virus infections, including rotavirus, norovirus, adenovirus, Enterovirus-A71, Coxsackievirus A6, and Echovirus 11. Furthermore, we discuss the gastrointestinal effects and pathogenic mechanisms of SARS-CoV-2 in intestinal epithelial cells, given the gastrointestinal symptoms observed during the COVID-19 pandemic. We conducted a literature review on their pathogenic mechanisms, which serves as a guide for formulating future treatment strategies for enteric virus infections.

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Clinical profile of children under 5 years of age with rotavirus diarrhoea in a hospital setting in Kisangani, DRC, after the introduction of the rotavirus vaccine, a cross-sectional study

Cited by 3 publications

References 26 publications

Rotavirus and adenovirus infections in children with acute gastroenteritis after introducing the Rotasiil® vaccine in Kisangani, Democratic Republic of the Congo

Rotavirus and adenovirus infections in children with acute gastroenteritis after introducing the Rotasiil® vaccine in Kisangani, Democratic Republic of the Congo

Effect of the COVID-19 Pandemic on Rotavirus Infection Frequency in Children

Overview of the Trending Enteric Viruses and Their Pathogenesis in Intestinal Epithelial Cell Infection

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