Clinical Profile of Cutaneous Adverse Drug Reactions in a Tertiary Care Centre

Prathap, Priya; M.I, Elsy; N, Ajitha K.; Kumar, Ajith; George, Sandhya

doi:10.21013/jas.v3.n3.p12

Cited by 2 publications

(3 citation statements)

References 7 publications

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“…This present study showed that the incidence of ACDRs were more in males 55.5% than in females 44.5%, with the male: female ratio 1.25:1. Our study showed male preponderance which was similar to the other studies carried out by Priya Prathap et al, Sharma VK et al, Shah SP et al 10,11,12 Moreover, others' studies like Chatterjee S et al, Sudarshan et al, Nandha R et al showed female preponderance.…”

Section: Discussionsupporting

confidence: 91%

Analysis of Cutaneous Adverse Drug Reactions on Using Commonly Prescribed Drugs at a Tertiary Care Hospital

Ciddhavaduta¹,

Samikrutha²,

Baloju³

2018

jebmh

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BACKGROUND Drugs can cure, suppress or prevent a disease and are usually beneficial to humans. However, they can also produce undesirable or harmful effects, which are known as adverse drug reactions (ADR). Understanding the nature of ACDRs may help narrow down the search for the offending agent. The need for this study is for early diagnosis, to reduce the morbidity and mortality due to ACDR and to ensure safety of the patients. MATERIALS AND METHODS The present study was carried out at Bhaskar general hospital under ICMR project, Department of Dermatology where in 27 patients of ADR were enrolled to establish the aetiologic agent for a particular type of reaction, attention was paid to the drug history, temporal correlation with the drug, duration of rash, approximate incubation period, morphology of the eruption, associated mucosal or systemic involvement, improvement of lesion on withdrawal of drug and recurrence of lesion on rechallenge. RESULTS This study showed that the incidence of ACDRs were more in males 55.5% than in females 44.5%. Most of the Cutaneous ADRs were probable in type under causality assessment and moderate under severity assessment. The presentation of cutaneous ADR was in the form of rash, urticaria, fixed drug eruption. Drugs causing these included NSAIDS, Antiepileptic's and antimicrobials. CONCLUSION Effective strategy to prevent the occurrence of ADRs is always preferred. Some of the measures that may reduce the occurrence of cutaneous ADRs are listed below. Avoid polypharmacy. Prescribe drugs, which have been known to cause cutaneous ADRs, only if extremely necessary. Obtain history of skin reactions in the past. Educate the patients regarding common early symptoms of drug reactions (e.g. erythematous rash, oedema, urticaria, mucosal erosions, itching, burning of skin etc.) especially during start of a therapy.

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Section: Discussionsupporting

confidence: 91%

Analysis of Cutaneous Adverse Drug Reactions on Using Commonly Prescribed Drugs at a Tertiary Care Hospital

Ciddhavaduta¹,

Samikrutha²,

Baloju³

2018

jebmh

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“…7 Prathap et al in India reported 71 cases with ACDR from 14,047 patients over one year, giving a prevalence rate of 0.5%. 8 However, that research included ACDR with all types of hypersensitivity reactions. The study results are influenced by the pharmacogenetic differences on different populations, the freedom to access medicine and healthcare, drugs dosage, use of suspected drugs, and other diseases or comorbidities.…”

Section: Discussionmentioning

confidence: 99%

“…6 Other studies also reported that antibiotics, NSAIDs, and antiepileptic drugs were the most frequent drugs that led to ACDR. 7,8 Antimicrobial agents and NSAIDs were considered common agents of ACDR. 5,17 In this study, the most frequent betalactams involved in ACDR were cefadroxil and amoxicillin.…”

Section: Discussionmentioning

confidence: 99%

A Five-Year Review of Adverse Cutaneous Drug Reaction in a Tertiary Care Hospital in Yogyakarta, Indonesia

Oktarina

Sophiati

Moha

et al. 2021

BIKK

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Background: The prevalence of adverse drug reactions is likely to increase, and it is associated with increased usage of various drugs. Adverse Cutaneous Drug Reaction (ACDR) is the most frequent adverse drug reaction (30–45%). In Indonesia, the study on the prevalence of ACDR is still limited. Purpose: This study investigated the prevalence, clinical features, causative agents, and mortality rate of ACDR with a type-IV hypersensitivity reaction among patients attending the Department of Dermatology and Venereology in Dr. Sardjito Hospital, Yogyakarta. Methods: This retrospective study was conducted examining medical records undertaken for five years (2011–2015). Of 68,375 patients medicated in the Department of Dermatology and Venereology, 397 patients were diagnosed as ACDR with a type-IV hypersensitivity reaction. Detailed history, including age, sex, past history, and family history of drug reaction taken by the patient, were obtained. Patch testing was done wherever feasible. Result: Of 68,375 patients, 397 patients were included in ACDR with type-IV hypersensitivity (0.58%), giving a 5% of mortality rate. The mean age of the patients was 40.42 years (±16.30; range 18 to 89 years). The female to male ratio was 1.1: 1. The Maculopapular rash was the most common ACDR manifestation (50.88%), followed by Stevens-Johnson Syndrome (13.85%), Fixed Drug Eruption (12.85%), and Drug Reaction with Eosinophilia and Systemic Symptoms (10.08%). The most common causative agents were beta-lactam (16.55%), NSAIDs (12.18%), and acetaminophen (8.62%). Conclusion: Prescription of those drugs should be considered carefully so the incidence of ACDR can be reduced.

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Clinical Profile of Cutaneous Adverse Drug Reactions in a Tertiary Care Centre

Abstract: Context: Cutaneous adverse drug reactions (cADR) constitute ( 8/71 ;11.3%) and urticaria (5/71 ;7%). Antimicrobials (40.8%), NSAIDS (22.5%) and Antiepileptics (22.5 %) were the common drugs responsible for these eruptions.

Cited by 2 publications

References 7 publications

Analysis of Cutaneous Adverse Drug Reactions on Using Commonly Prescribed Drugs at a Tertiary Care Hospital

Analysis of Cutaneous Adverse Drug Reactions on Using Commonly Prescribed Drugs at a Tertiary Care Hospital

A Five-Year Review of Adverse Cutaneous Drug Reaction in a Tertiary Care Hospital in Yogyakarta, Indonesia

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