Clinical profile of essential hypertensives based on ion-transport abnormalities

Sierra, Alejandro de la; Coca, António; Paré, Juan C.; Sobrino, Javier; Sánchez, María del Mar; Paz, Marco A.; Jiménez, V. Hernández; Urbano-Márquez, Á

doi:10.1097/00004872-199112006-00138

Cited by 2 publications

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“…With respect to the factors associated with better response to treatment, three studies conducted in Spain coincide with us in indicating baseline BP as the factor most closely linked to response to treatment. 20 -22 Sierra et a/ 20 conclude that patients having the highest SBP and DBP are worse responders to AHT treatment in the form of monotherapy, a conclusion shared by Campo et al 21 Similarly, in a recent study analysing factors associated with control of BP, multivariate analysis showed that SBP maintained its significance as a predictor of control, with an RR of 1.14 (Cl 1.09-1.21), a result similar to that observed for our patients. 22 In our study, the observed decrease in SBP and DBP figures was less for patients who received concomitant treatment than for those who received doxazosin in monotherapy, which logically translated as a worse percentage of control.…”

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confidence: 99%

Safety and Effectiveness of Replacing Standard Doxazosin With Doxazosin in the Gastrointestinal Therapeutic System (Gits) Formulation in Elderly Hypertensive Patients

Jiménez-García

Anegón

Esteban

et al. 2003

Int J Clinical Practice

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SUMMARYThe objective of this paper is to evaluate the safety and effectiveness of using doxazosin standard formulation in elderly hypertensive patients who were either uncontrolled or newly diagnosed, and replacing standard doxazosin with doxazosin in the gastrointestinal therapeutic system (GITS) formulation. We designed a postmarketing surveillance, open‐label non‐comparative, multicentre, clinical study covering primary care patients aged 65 years or older diagnosed with essential uncontrolled arterial hypertension. The study covered a period of 6–9 months, divided into two phases. Phase I involved a minimum of three and maximum of six months in treatment with standard doxazosin; phase II began with the changeover from standard doxazosin to the GITS formulation and lasted 12 weeks. Of the 1705 patients initially enrolled, 1292 (75.8%) completed the study. Reduction in systolic blood pressure was 22.3 mmHg (13.7%) in phase I, and 3.9 mmHg (2.77%) in phase II; reduction in diastolic blood pressure was 12.4 mmHg (13.2%) in phase I, and 2.4 mmHg (2.9%) in phase II. The percentage of controlled patients was 40.5% (691/1705) by the end of phase I and 45.3% (776/1705) by the end of phase II. A total of 154 patients suffered adverse events (AE), 127 during phase I and 27 in phase II. We conclude that doxazosin in its two formulations is effective and safe for the purpose of lowering blood pressure in elderly patients.

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Section: Discussionmentioning

confidence: 99%

Safety and Effectiveness of Replacing Standard Doxazosin With Doxazosin in the Gastrointestinal Therapeutic System (Gits) Formulation in Elderly Hypertensive Patients

Jiménez-García

Anegón

Esteban

et al. 2003

Int J Clinical Practice

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pH _i Regulation in Myocardium of the Spontaneously Hypertensive Rat

Pérez

Álvarez

Hurtado

et al. 1995

Circulation Research

102

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To elucidate the mechanisms controlling pHi in myocardium of the spontaneously hypertensive rat (SHR), experiments were performed in papillary muscles (isometrically contracting at 0.2 Hz) from SHR and age-matched normotensive Wistar-Kyoto (WKY) rats loaded with the pH-sensitive fluorescent probe BCECF-AM. An enhanced activity of the Na(+)-H+ exchanger was detected in the hypertrophic myocardium of SHR. This conclusion was based on the following: (1) The myocardial pHi was more alkaline in SHR (7.23 +/- 0.03) than in WKY rats (7.10 +/- 0.03) (P < .05) in HEPES buffer. (2) SITS (0.1 mmol/L in HEPES buffer) did not alter pHi in the SHR (pHi 7.26 +/- 0.03 and 7.28 +/- 0.03 before and after SITS, respectively). (3) The fall in pHi observed after 20 minutes of Na(+)-H+ exchanger inhibition [5 mumol/L 5-(N-ethyl-N-isopropyl)amiloride (EIPA)] was greater in SHR (-0.16 +/- 0.01) than in WKY rats (-0.09 +/- 0.02, P < 0.05). (4) The velocity of pHi recovery from an intracellular acid load was faster in SHR than in WKY rats (0.068 +/- 0.02 versus 0.014 +/- 0.002 pH units/min at pHi 6.99, P < .05). (5) After EIPA inhibition, the rate of pHi recovery from the same acid load decreased to a similar value in both rat strains (0.0032 +/- 0.002 pH units/min in SHR and 0.0032 +/- 0.002 pH units/min in WKY rats). Under the more physiological HCO3(-)-CO2 buffer, no significant difference in steady state myocardial pHi was detected between rat strains (7.15 +/- 0.03 in SHR and 7.11 +/- 0.05 in WKY rats).(ABSTRACT TRUNCATED AT 250 WORDS)

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Clinical profile of essential hypertensives based on ion-transport abnormalities

Cited by 2 publications

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Safety and Effectiveness of Replacing Standard Doxazosin With Doxazosin in the Gastrointestinal Therapeutic System (Gits) Formulation in Elderly Hypertensive Patients

Safety and Effectiveness of Replacing Standard Doxazosin With Doxazosin in the Gastrointestinal Therapeutic System (Gits) Formulation in Elderly Hypertensive Patients

pH _i Regulation in Myocardium of the Spontaneously Hypertensive Rat

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Clinical profile of essential hypertensives based on ion-transport abnormalities

Cited by 2 publications

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Safety and Effectiveness of Replacing Standard Doxazosin With Doxazosin in the Gastrointestinal Therapeutic System (Gits) Formulation in Elderly Hypertensive Patients

Safety and Effectiveness of Replacing Standard Doxazosin With Doxazosin in the Gastrointestinal Therapeutic System (Gits) Formulation in Elderly Hypertensive Patients

pH i Regulation in Myocardium of the Spontaneously Hypertensive Rat

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pH _i Regulation in Myocardium of the Spontaneously Hypertensive Rat