Clinical Profile of Non-Motor Symptoms in Patients with Essential Tremor: Impact on Quality of Life and Age-Related Differences

Shalash, Ali; Mohamed, Hadeer; Mansour, Alia H.; Elkady, Ahmed; Elrassas, Hanan; Hamid, Eman; Elbalkimy, Mahmoud

doi:10.7916/tohm.v0.736

Cited by 12 publications

(12 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Four of these articles subdivided the number of participants according to each Hoen&Yarh subgroup (HYI-n=159, HY2n=508, HYIII, n=233, HYIV n=132, HYV=22, HY2.5=n=32). To assess he essential tremor severity, the Fahn-Tolosa-Marin Tremor Rating Scale (FTMTRS) was used [11][12][13] .…”

Section: Resultsmentioning

confidence: 99%

“…The Geriatric Depression Scale -15 (GDS-15) [18] , Depression Anxiety Stress Scale (DASS) [14,17] , Hospital Anxiety and Depression Scale (HADS) [19][20][21] , and Beck Depression Inventory-BDI [12,[22][23][24] were used in 10 studies to assess neuropsychiatric symptoms. Most patients included were affected by mild or moderate neuropsychiatric illness and in two studies this condition was not identified [17,24] .…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Factors that Impact on Quality of Life of People with Disease with Tremor: Systematic Review

Gomes

Gomes²,

Celinski³

et al. 2022

ijirms

View full text Add to dashboard Cite

Background: Parkinson’s disease and essential tremor are common diseases that cannot be cured. These diseases cause a major impact on the patients’ lifestyle, and as they are progressive over time, their symptoms tend to get worse as well as these individuals’ quality of life. Objective: To analyze how the duration of the disease impact quality of life and other aspects related to the disease. Methods: A systematic review was carried out, and a meta-analysis developed including original articles published after 2006 that assessed the quality of life of patients with diseases that presented tremor as a symptom. Results: The number of papers found totaled 7.114, out of those, 27 were included in the systematic review, and 15 of them were also included in the meta-analysis. The articles found analyzed sociodemographic, neuropsychiatric scales, and disease severity scales. In the meta-analysis we found that the time of disease impacts the score of PDQ-39 in numbers of dominants, the mini-mental score, and the UPDRS score. Conclusion: Longer time of disease since diagnostic results in a negative impact on the patients’ quality of life, cognition, emotional status, activities of daily living, motor examination, and therapy complication.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Factors that Impact on Quality of Life of People with Disease with Tremor: Systematic Review

Gomes

Gomes²,

Celinski³

et al. 2022

ijirms

View full text Add to dashboard Cite

show abstract

“…Our study demonstrated that 95.5% of patients with ET had at least 1 comorbidity, 79.7% had at least 3 comorbidities, and 56.9% JOURNAL OF HEALTH ECONOMICS AND OUTCOMES RESEARCH had at least 5 comorbidities. Multiple comorbidities are associated with poor health outcomes: decreased quality of life, 32,[35][36][37] increased psychological distress, 38 longer LOS, worse postoperative complications, and higher HCC and mortality. 24,[39][40][41] The interplay between multimorbidity and chronic disease is extremely important but receives inadequate attention in many chronic conditions.…”

Section: Discussionmentioning

confidence: 99%

“…While traditionally regarded as benign, ET is in fact a chronic, progressive, and disabling neurological disease that causes uncontrolled rhythmic shaking, most often affecting the hands. [7][8][9] It is characterized by the presence of an action tremor as well as a myriad of symptoms such as gait disturbances, postural instability, and cognitive impairment. 7,9 These symptoms may worsen over time and significantly impact a patient's quality of life and ability to perform activities of daily living.…”

Section: Journal Of Health Economics and Outcomes Researchmentioning

confidence: 99%

Multiple Comorbidities, Psychiatric Disorders, Healthcare Resource Utilization and Costs Among Adults with Essential Tremor: A Retrospective Observational Study in a Large US Commercially Insured and Medicare Advantage Population

Dai

Samiian²,

Fernandes

et al. 2022

JHEOR

View full text Add to dashboard Cite

Background: Essential tremor (ET), the most common movement disorder, often impairs patients’ ability to perform activities of daily living, mental health, and quality of life. Objectives: To assess comorbidities, psychiatric disorders, healthcare resource utilization (HCRU), and costs among patients with ET compared with patients without ET. Methods: This retrospective observational study was conducted using a large US administrative claims database. Patients with ET were identified during the study period (1/1/2017–12/31/2019). The earliest claim date with ET diagnosis was identified as the index date. An index date was assigned randomly for each non-ET patient. Patients had to be at least 22 years old and be enrolled in the health plan for at least 6 months before and at least 12 months after the index date. Patients with and those without ET were matched 1:1 on age, gender, payer type, and first 3 digits of their ZIP code. Comorbidities were assessed using data within 6 months prior to the index date. Psychiatric disorders, HCRU, and costs were examined using data within 12 months after the index date. Results: The mean (SD) age of ET patients (n = 5286) was 70.8 (11.8) years, 49.1% were female, and 82.9% were Medicare Advantage members. In the 12 months following the index date, 26.0% of patients had no insurance claims for ET-related pharmacotherapy or invasive therapies. Patients with ET had a higher number of comorbidities than non-ET patients (5.3 [3.2] vs 4.0 [3.3]); a higher prevalence of psychiatric disorders (depression: 25.6% vs 15.3%; adjusted odds ratio (AOR) [95% CI], 1.56 [1.41-1.73]; anxiety: 27.7% vs 15.5%, AOR: 1.78 [1.61-1.96]); and higher total healthcare costs: $17 560 [$39 972] vs $13 237 [$27 098], adjusted cost ratio [95% CI]: 1.11 [1.06-1.16]; all P<.0001. Discussion: Highly prevalent multiple comorbidities and psychiatric disorders should be considered in the context of clinical decision-making to optimize ET management. Conclusions: This study represents the largest observational study to report ET disease and economic burdens in a real-world setting. The data demonstrate increased comorbidity, mental health, and healthcare cost burdens among ET patients compared with matched non-ET patients. These findings underscore the need for innovative care for this complex population.

show abstract

“…The prevalence of ET among individuals aged between 18 and 60 was 1.60% ( 30 ). Recent studies have revealed that these non-motor features occur similarly in younger and elder patients ( 31 ). A study that included 45 young patients with ET and 35 age-matched controls showed that compared with the control group, depressive and anxiety symptoms were more common in the ET group, while total MoCA scores were lower in the ET group ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

Association of Essential Tremor With Dementia and Affective Disorders: A Meta-Analysis

Shang

Chen

et al. 2022

Front. Neurol.

View full text Add to dashboard Cite

BackgroundThe dementia and affective disorders are common non-motor features in patients with essential tremor (ET). However, the relationship of ET with cognitive impairments and affective disorders remains controversial. This meta-analysis aimed to analyze the association of ET with dementia and affective disorders.MethodsOriginal studies published from January 1999 to October 2019 were systematically searched from the database of Medline (OvidSP), EMBASE (OvidSP), and the Cochrane Central Register of Controlled Trials. Pooled standard mean difference (SMD, random effect model), odds ratios (ORs), relative risk (RR), and 95% CI were calculated.ResultsCompared with the Non-ET group, patients with ET had significantly lower Mini-Mental State Examination (MMSE) score (SMD, −1.16; 95% CI, −1.75 to −0.58; p = 0.0001) and had significantly higher depressive and anxiety symptoms scale score (SMD, 0.55; 95% CI, 0.22–0.87; p = 0.0009). The OR for dementia and affective disorders in individuals with ET compared with individuals without ET was 2.49 (95% CI, 2.17–2.85, p < 0.00001). While there was no significant difference in Montreal Cognitive Assessment (MoCA) score between ET and Non-ET groups (SMD, −0.52; 95% CI, −0.16 to 0.13; p = 0.23), there was a significant difference in the risk of mortality between ET and Non-ET groups (RR = 4.69, 95% CI, 2.18–10.07).ConclusionThe non-motor symptoms should not be neglected among patients with ET. However, the causal relationship between ET and dementia, depression, and anxiety is unclear.

show abstract

Clinical Profile of Non-Motor Symptoms in Patients with Essential Tremor: Impact on Quality of Life and Age-Related Differences

Cited by 12 publications

References 38 publications

Factors that Impact on Quality of Life of People with Disease with Tremor: Systematic Review

Factors that Impact on Quality of Life of People with Disease with Tremor: Systematic Review

Multiple Comorbidities, Psychiatric Disorders, Healthcare Resource Utilization and Costs Among Adults with Essential Tremor: A Retrospective Observational Study in a Large US Commercially Insured and Medicare Advantage Population

Association of Essential Tremor With Dementia and Affective Disorders: A Meta-Analysis

Contact Info

Product

Resources

About