Clinical profile of organophosphate poisoning at a tertiary-care center

Shah, Nehal; Mundhra, Shashikumar H

doi:10.5455/ijmsph.2016.15102015267

Cited by 6 publications

(9 citation statements)

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“…Unlike a study from Nepal [2], in our study, male population was more affected because of organophosphorus poisoning. Our results are similar to other studies from India [16][17][18], showing more occurrence of poisoning in male population compared to female population. As reported in other studies [2,16], people from working population were more commonly affected in our study too.…”

Section: Discussionsupporting

confidence: 92%

“…Our results are similar to other studies from India [16][17][18], showing more occurrence of poisoning in male population compared to female population. As reported in other studies [2,16], people from working population were more commonly affected in our study too. The results of our study suggest that working male population is more affected by organophosphorus poisoning.…”

Section: Discussionsupporting

confidence: 92%

“…Mortality rate due to organophosphorus poisoning in our study was similar to that of reported in another study from Gujarat [16].…”

Section: Discussionsupporting

confidence: 91%

“…More than 5 days of stay in the hospital is common for patients with organophosphorus compound poisoning [16]. In our study, the mean duration of stay in ICU was 7.3 days.…”

Section: Discussionmentioning

confidence: 48%

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Characteristics of Patients With Organophosphorus Poisoning and Its Management: Pharmacoepidemiological Evaluation

Kulkarni

Patil

2019

Asian J Pharm Clin Res

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Objective: The objective of this study was to analyze demographics, management pattern, and clinical outcomes in patients with organophosphorus poisoning. Methods: In this subgroup analysis of retrospective data of patients admitted in intensive care unit (ICU) with a diagnosis of acute organophosphorus poisoning, demographic details, pattern of use of medicines, dose of atropine and pralidoxime (PRAM), duration of ICU stay, and clinical outcomes were analyzed. Results: A total of 92 patients with organophosphorus poisoning (mean age 34.7 years; male 69 [75%]) were included. The age of male patients was more than female patients (36.2 vs. 30.0 years; p=0.047). Atropine and PRAM were given to all patients. Ondansetron was used in all patients, whereas ranitidine was used in 91 (98.9%) patients. The mean total dose of atropine in male and female population was 99.5 mg and 89.0 mg, respectively (p=0.298). The mean total dose of PRAM in male and female population was 12.2 mg and 12.0 mg, respectively (p=0.772). There was no difference in the mean (standard deviation) duration of stay in ICU between male patients and female patients (7.6 [4.5] vs. 6.4 [3.9] days; p=0.249). A total of 61 (66.3%) patients were transferred to the ward, whereas 30 (32.6%) died. Conclusion: Atropine and PRAM are the primary drugs for the treatment of organophosphorus poisoning. Ondansetron and ranitidine are useful drugs for the treatment of vomiting and gastric irritation, respectively, in these patients.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

“…Mortality rate due to organophosphorus poisoning in our study was similar to that of reported in another study from Gujarat [16].…”

Section: Discussionsupporting

confidence: 91%

“…More than 5 days of stay in the hospital is common for patients with organophosphorus compound poisoning [16]. In our study, the mean duration of stay in ICU was 7.3 days.…”

Section: Discussionmentioning

confidence: 48%

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Characteristics of Patients With Organophosphorus Poisoning and Its Management: Pharmacoepidemiological Evaluation

Kulkarni

Patil

2019

Asian J Pharm Clin Res

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“…It may also affect respiration which may endanger the individual's life. 2 Mortality rate depends upon the amount and type of compound, condition of the patient on arrival at hospital, delay in diagnosis and treatment and respiratory management. There was always correlation with the type of compounds, pre-hospitalisation period, type of management and they are useful for preventing the mortality rate in developing countries such as India.…”

mentioning

confidence: 99%

Profile of organo phosphorous poisoning at a tertiary medical centre in Jharkhand, India

et al. 2018

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Background: Poisoning is the most common method, employed for the act of deliberate self-harm. The wide availability, lack of rules and regulations for the sale of pesticides resulted in wide spread use of Organophosphate as one of the most common poison used for deliberate self-harm.Methods: In this study, authors aim to find out clinical profile with respect to different O.P. compounds, prognosis and outcome of each patient in relation to the delay in getting medical attention. Present study objective is to find out if there is any specific clinical finding which can predict bad outcome.Results: Out of 344 cases, 189 cases had type 1 respiratory failure, while in 34 cases type II respiratory failure present. 61 cases expired and out of these 61 cases 47 cases died within 24 hours and 11 cases died in next 48 hours.Conclusions: Maximum number of cases were in the age group of 21 - 30years. The maximum number of deaths were in the first 72 hours. Number of cases were more in males as compared to females. Chances of survival was better in persons who reached early to the hospital.

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Study of Prevalence, Clinical Pattern and Outcome of Acute Organophosphate Poisoning Patients Admitted in Al Gamhouria Teaching Hospital and Private Hospital and in Aden City - Yemen

GABALI

2021

The Medical Journal of Cairo University

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Background: Organophosphates (OP) are one of the most common agents of poisoning in developing countries including Yemen. Where agriculture is a major component of the economy. Aim of Study:This study aimed to describe the prevalence, clinical pattern and outcome of patients with organophosphorus poisoning admitting a private hospital and in Al-Ggamhouria Teaching Hospital in Aden city in Yemen.Patients and Methods: It was a prospective study carried out in Al-Gamhouria Teaching Hospital and Private Hospital in Aden-Yemen over a period of two years, Between August 2019 to August 2021. It included 50 patients >16 years of age presented with organophosphates poisoning within 6 hours of OP exposure. Diagnosis was performed from the history taken from the patient, particular focus being given for sex, age, rural/urban background, clinical symptomatology, in addition to outcome.Results: During the study period, 50 patients were recruited, mean age was 32 ± 10 years, (62%) cases were females and (38%) were males, maximum of patients belonging to the age group of 21-40 years (70%), sweating was the most common clinical pattern at time of arrival, it was (92%) follow by Miosis (80%) excessive salivation (68%) bradycardia 50% muscle weakness (10%). Dead patients are (26%) of the subjects, while (74%) of patients were fully recovered. Conclusion:This study concluded that young female patients are the majority of patients with OP poisoning encountered in hospitals, and sweating is the commonest presentation seen.

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Clinical profile of organophosphate poisoning at a tertiary-care center

Cited by 6 publications

References 0 publications

Characteristics of Patients With Organophosphorus Poisoning and Its Management: Pharmacoepidemiological Evaluation

Characteristics of Patients With Organophosphorus Poisoning and Its Management: Pharmacoepidemiological Evaluation

Profile of organo phosphorous poisoning at a tertiary medical centre in Jharkhand, India

Study of Prevalence, Clinical Pattern and Outcome of Acute Organophosphate Poisoning Patients Admitted in Al Gamhouria Teaching Hospital and Private Hospital and in Aden City - Yemen

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