Clinical profile of patients with thrombocytopenia at tertiary health care centre

Patne, Sanjay V.; Chintale, Kailash N.

doi:10.18203/2349-3933.ijam20175082

Cited by 4 publications

(4 citation statements)

References 3 publications

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“…Among all the study populations, 6.1% of patients had septicemia. Patne et al, Gondhali et al, Modi et al, and Raikar et al had similar findings to this study that viral infection like dengue fever is the most common cause of febrile thrombocytopenia [ 3 , 14 - 16 ], whereas Gandhi et al and Kumbhar et al found malaria as the common etiology for fever with thrombocytopenia [ 17 - 19 ]. Other rare causes include septicemia, enteric fever, and hematological malignancy like ALL.…”

Section: Discussionsupporting

confidence: 83%

Spectrum of Febrile Thrombocytopenia in the Pediatric Population (1-18 Years) Admitted in a Tertiary Care Center

Deshpande,

Gupta,

Pandya

et al. 2023

Cureus

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Aim Thrombocytopenia is a common manifestation of various infections. Thrombocytopenia associated with fever helps to narrow down the differential diagnosis and management of fever. It also helps to know the various complications of thrombocytopenia, its management, and the outcome of the patient. This study aimed to evaluate the clinical profile and determine etiology and complications in patients with fever and thrombocytopenia in pediatric populations. Methods One hundred and fifteen patients of both sexes aged 1-18 years with fever and found to have thrombocytopenia (platelet count < 1.5 lakhs) between June 1, 2018 and March 31, 2019 were included in this study. Results Infection was the common cause of febrile thrombocytopenia and dengue fever was the most common infection. Bleeding manifestations were seen in 9.6 % of patients. Petechiae/purpura was the commonest bleeding manifestation followed by gum and nose bleeding. Common bleeding manifestations were seen in patients with a platelet count below 50,000 and the majority of them did not require platelet transfusion. Good recovery was noted in 96.5% of patients while 2.6% had mortality. Conclusions An infection, particularly dengue, was the common most cause of fever with thrombocytopenia. In the majority of patients, thrombocytopenia was transient and asymptomatic. Bleeding was present in the majority of patients with platelets less than 10,000 and 20,000 to 50,000. The most common bleeding manifestation was petechial rashes over the skin. Platelet transfusion was not required in most of the cases. On treating the specific cause, a drastic improvement in the platelet count was noted during discharge and further follow-up. Immunization is highly recommended for vaccine-preventable diseases.

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Section: Discussionsupporting

confidence: 83%

Spectrum of Febrile Thrombocytopenia in the Pediatric Population (1-18 Years) Admitted in a Tertiary Care Center

Deshpande,

Gupta,

Pandya

et al. 2023

Cureus

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“…Other bleeding manifestations included haemoptysis in three (5%) patients, haematuria in two (3.33%), and epistaxis in two (3.33%) patients. According to PatneSV et al, bleeding manifestations were present in 37.50% of patients, and the most common site of bleeding was the skin and mucous membrane [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…According to PatneSV et al, bleeding manifestations were present in 37.50% of patients, and the most common site of bleeding was the skin and mucous membrane [11].…”

Section: Figure 3: Haemorrhagic Manifestations Associated With Thromb...mentioning

confidence: 99%

Study of the Aetiology and Clinical Manifestations of Thrombocytopenia in a Tertiary Care Centre

Choudhary¹,

Mishra²,

Kumar³

et al. 2023

Cureus

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Introduction Thrombocytopenia is a commonly observed condition in clinical practice, and its diagnosis is often challenging due to numerous aetiologies and variations in clinical presentation. Early identification of thrombocytopenia and its causes can help prevent life-threatening haemorrhagic manifestations. Methodology A prospective observational study was conducted at a tertiary care hospital from February 2019 to January 2020. This evaluation aimed to determine the causes and prevalence of thrombocytopenia in a tertiary care setting. Patients aged 15 or older with a platelet count of fewer than 150,000/ µL were eligible for inclusion in this evaluation. Investigations for aetiology detection were recommended. Results During the one-year study period, a total of 100 patients, including 58 males and 42 females, with thrombocytopenia were selected for the study. The most common age group affected by thrombocytopenia in this study was between 46 and 55 years old. The most common clinical manifestations observed were generalised weakness (70%), haemorrhagic manifestations (60%), fever (50%), joint pain (37%), splenomegaly (35%), headache (30%), breathlessness (23%), lymphadenopathy (22%), hepatomegaly (24%), and abdominal pain (12%). The most prevalent causes of thrombocytopenia were megaloblastic anaemia (19 cases), dengue fever (15 cases), malaria (11 cases), enteric fever (nine cases), immune thrombocytopenia (ITP) (eight cases), and leukaemia (seven cases). Bleeding was reported as a symptom of thrombocytopenia in 60% of individuals in this study. Conclusion In the study, thrombocytopenia was more common in people aged 46-55 years, and males were more commonly affected than females. Megaloblastic anaemia and infectious disease were the most common causes of thrombocytopenia. Bleeding manifestations were found in 60% of patients with thrombocytopenia.

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“…The study conducted by Patne et al showed that thrombocytopenia was caused due to infections in 63.33% patients [9]. Considering p= 0.6333, q= 0.3667, Z=1.96 for confidence level of 95% and d (absolute precision) = 0.1, sample size was calculated to be 92.…”

Section: Sample Size Calculationmentioning

confidence: 99%

Observational study on clinicopathological profile of thrombocytopenia cases in a medical college hospital

Kumar¹,

Priyadarshi²,

Kumar³

et al. 2019

Trop J Pathol Microbiol

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Introduction: Thrombocytopenia is a commonly encountered condition with varying aetiologies ranging from infective to chronic conditions and malignancies. Knowledge of causes and pattern of disease is helpful in management of cases. Aims & objectives: The present study was conducted to assess the causes, clinical profile and findings of laboratory investigations of patients suffering from thrombocytopenia. Material & Methods: The present cross-sectional hospitalbased study was conducted upon 99 patients suffering from thrombocytopenia. Detailed clinical history, physical examination and reports of laboratory investigations were noted. Results: 34.3% patients belonged to the age group of 21-30 years. 57.6% of them were males. Thrombocytopenia was mild (1,00,000-1,50,000) in 24.2% patients, moderate (50,000-1,00,000) in 52.5% and severe (<50,000) in 23.2%. Dengue accounted for 31.3% cases, malaria for 16.2%, enteric fever for 7.1% and septicaemia for 3%. Megaloblastic anaemia was responsible in 24.2% cases. Most common site for bleeding was skin and mucous membrane where bleeding manifested in the form of petechiae, purpura and ecchymosis (18.2%). Conclusion: Knowledge of causes and pattern of disease is helpful in management of cases.

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Clinical profile of patients with thrombocytopenia at tertiary health care centre

Cited by 4 publications

References 3 publications

Spectrum of Febrile Thrombocytopenia in the Pediatric Population (1-18 Years) Admitted in a Tertiary Care Center

Spectrum of Febrile Thrombocytopenia in the Pediatric Population (1-18 Years) Admitted in a Tertiary Care Center

Study of the Aetiology and Clinical Manifestations of Thrombocytopenia in a Tertiary Care Centre

Observational study on clinicopathological profile of thrombocytopenia cases in a medical college hospital

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