Clinical profile of patients with acute ischemic stroke receiving intravenous thrombolysis (rtPA-alteplase)

Abstract

Background: Stroke patients are at highest risk death in the first few weeks after the event, and between 20-50% die within first month depending on type, severity, age, co-morbidities and effectiveness of treatment of complications. Objective of this study was to clinical profile of patients with acute ischemic stroke receiving intravenous thrombolysis (rtPA-alteplase).Methods: Prospective Observational study of 26 cases of acute ischemic stroke receiving IV thrombolysis using rtPA-alteplase at Kovai Medical Centre Hospital, Coimbatore over a period of 1 year 9 months.Results: 21 cases had NIHSS score of range 10 to 22. The mean NIHSS score at admission is 13.5. 15 subjects (57.7%) had achieved primary outcome in this study. MRS Score of 0 to 2 is considered as favorable outcome. In this study 20 subjects (76.92 %) had favorable outcome at the end of 3 months.Conclusions: Majority of the patients receiving rtPA-alteplase had favorable outcome.

Clinical profile of patients with acute ischaemic stroke undergoing thrombolysis in a tertiary hospital- A retrospective observational study

“…The door to needle time-time taken from the arrival in ER to the start of the lysis was found to be a mean of 66 minutes. This was comparable with other studies including Jagini et al 19 Delay in decision making by patient relatives and also delays in shifting of patient contributed to cases with prolonged door to needle time.…”

“…The mean SBP is159 mmHg and mean DBP is 89 mmHg which correlates well with other studies including the study done by Qureshi AI et al 18 In this study, the mean time period from onset of symptoms to presentation in ER -Window time-was 148 minutes. This was lesser compared to the window period time in studies including Jagini et al 19 and Ramasamy et al72 percent of cases presented within 3 hours while the rest presented in the extended window period of 3 to 4.5 hours.…”

Autonomy Outcomes Measured with Barthel Index in Patients with Ischaemic Stroke during SARS-CoV-2 Pandemic. A Descriptive Study

“…Compared to other studies, our results are similar. Jagini and Suresh [33] determined an asymptomatic-mild degree of disability in 75% of their sample and moderate-severe incapacity in 25% at three months. Another study determined that 25% of their sample improved their mRS values by one or more degrees between 3 months and 1 year [34].…”