Clinical Profile of Pediatric Onset vs Adult-Onset Multiple Sclerosis

Abstract

We can summarise our conclusion from the current study in the following points:•Early disease onset does not necessitate a higher relapse rate when including the full spectrum of POMS variants into consideration and following the patients for a longer interval.•Median times to reach advanced EDSS scores and secondary progression were longer in POMS than in AOMS.•Most of our POMS group were started on first-line DMT compared to of AOMS patients. Nonetheless, POMS patients had on average more relapses on the first line and were escalated to second-line DMTs compared to adults.•POMS patients who had infratentorial patches in the initial MRI significantly had a higher EDSS score than patients who did not.•IgG index had a significant and positive correlation to the current EDSS score and the rate of EDSS progression in POMS. This study was a cross-sectional study that included MS patients who visited the MS clinic of the neuropsychiatry department, Alexandria University from January 2019 to January 2021. We entered their epidemiological, clinical, radiological data, and CSF results from their updated records as well as follow up interviews.