Clinical profile of pregnant women with systemic lupus erythematosus of the Hospital de Clínicas of the UFPR

Schade, Lilian; Paiva, Eduardo dos Santos; Sbalqueiro, Renato Luiz; Nascimento, Denis José; Azevedo, Valderílio Feijó

doi:10.11606/issn.2176-7262.v50i3p169-176

Cited by 1 publication

(2 citation statements)

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“…The presence of active lupus at conception is associated with worse maternal and foetal prognosis (20), and can be a predictor of perpetuation of activity throughout gestation. Patients who have active SLE at conception may have up to twice as much risk of activity during pregnancy and 3.5 times higher risk of FGR (21)(22)(23).…”

Section: Discussionmentioning

confidence: 99%

“…In our study, all severe cases (birth weight below 3 rd percentile and/or Doppler abnormalities) were accurately identified during routine ultrasound screening, performed monthly after 24 weeks in our center. This diagnostic accuracy for FRG is better when foetal biometry evaluation is associated with the analysis of uterine and foetus-placental circulation by Doppler velocimetry, which was used in all cases (19,21). The evaluation of anti-angiogenic and angiogenic cytokines, such as sFlt-1 and PIGF, may also help identify women at higher risk of placenta-mediated complications like FGR, as they are strongly associated with Doppler velocimetry changes and histological signs of placental hypoperfusion (21,22,42).…”

Section: Discussionmentioning

confidence: 99%

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The association between active proliferative lupus nephritis during pregnancy and small for gestational age newborns

Lacerda

Rodrigues

Jesús

et al. 2021

Clinical and Experimental Rheumatology

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ObjectiveTo analyse maternal variables associated with occurrence of small for gestational age (SGA) newborns in pregnancies of women with systemic lupus erythematosus (SLE), considering clinical and laboratory characteristics prior to conception, during gestation and comorbidities. Methods Retrospective cohort study with SLE pregnant patients and singleton deliveries after 22 weeks. SGA newborn was defined as birth weight below 10 th percentile and SLE activity at conception and during gestation was measured usingthe SLE Pregnancy Disease Activity Index (SLEPDAI). Univariate analysis was employed to evaluate individual influence of demographic and clinical variables on the SGA newborn outcome, while variables with p<0.20 were included in multivariate regression.

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Section: Discussionmentioning

confidence: 99%