Clinical Profile of SARS-CoV-2 Infected Neonates From a Tertiary Government Hospital in Mumbai, India

Kalamdani, Pavan; Kalathingal, Thaslima; Manerkar, Swati; Mondkar, Jayashree

doi:10.1007/s13312-020-2070-9

Cited by 26 publications

(24 citation statements)

References 11 publications

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“…In a case series by Hu Z et al of 24 asymptomatic infections, four (16.7%) cases had lymphopenia and other four had leukopenia Zimmermann et al noted that the white blood cell count is typically normal or reduced with decreased neutrophil and/or lymphocyte counts. 9 In our study, marked elevation of d-dimer (45%), Serum ferritin and Fibrinogen in 27% each and leucopenia (36%) were observed in the SARS-CoV-2 positive neonates and all of them recovered without any specific treatment. 8 De Bernardo, et al has reported radiological abnormalities in 44% of SARS-CoV2 positive neonates but we did not find any radiological abnormalities in our study.…”

Section: Discussionsupporting

confidence: 50%

Symptomatic neonatal SARS-CoV-2 infection in a tertiary care teaching hospital: an observational prospective study

Ambike

Haribhakta

Soni

et al. 2021

Int J Contemp Pediatr

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Background: The likelihood of newborns acquiring severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) from infected mothers has raised concerns among families and clinicians worldwide. The disease seems to be mild in children and, to date; there are few reports in neonatal population. The aim of the study was to study the Prevalence of Neonatal SARS-CoV-2 infection in a tertiary care teaching hospital. The objective of the study was to study correlation of clinical features and laboratory parameters among SARS-CoV-2 positive neonates.Methods: Prospective observational study conducted in a dedicated COVID-19 tertiary care hospital and Postgraduate Institute in Pune, Maharashtra between May 2020 and August 2020 on a sample size of 55 COVID suspect neonates as they were admitted and diagnosed during the pandemic.Results: Out of 250 COVID positive mothers admitted, 55 COVID suspect neonates were admitted as their mothers were symptomatic. Among 55 suspect neonates, 11 turned out to be positive (20%). Out of 11 COVID positive neonates, tachypnea with requirement of non-invasive O2 in 2 (18%), feeding intolerance in 2 (18%), fever in 2 (18%) rash 1 (9%) was seen. out of the 11 COVID positive neonates admitted, 45% had elevated D-Dimer levels, 36% had elevated Leucocyte counts, 27% each had raised serum ferritin and fibrinogen levels and 18% had raised CRP Levels.Conclusions: We conclude that inspite of the first wave of COVID seen in neonates which was rare then, clinical and laboratory markers showed a good co-relation in our study in all neonates who were COVID positive but there was no radiological co-relation in any. However, all recovered with symptomatic treatment without any specific COVID treatment.

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Section: Discussionsupporting

confidence: 50%

Symptomatic neonatal SARS-CoV-2 infection in a tertiary care teaching hospital: an observational prospective study

Ambike

Haribhakta

Soni

et al. 2021

Int J Contemp Pediatr

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“…CoV-2 infection (Kalamdani et al, 2020). It is important to remark that in our study, none of the neonates had been breastfed by their mother before samples were taken.…”

Section: Discussionmentioning

confidence: 88%

Study of perinatal transmission of SARS-CoV-2 in a Mexican public hospital

Ramírez-Rosas¹,

Benítez-Guerrero²,

Corona-Cervantes³

et al. 2021

International Journal of Infectious Diseases

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“…In a study by Kalamdani et al, involving another public sector hospital involving a large cohort of 12 neonates, few had symptoms and none of them required NICU admission. However, all of them were >34 weeks of gestation and >2 kg [2]. In a study by Shah et al from a large referral tertiary center involving 18 neonates, they observed that all were symptomatic, 15 recovered and three succumbed, and no contact was identifiable in 8 (44%) of the babies [3].…”

Section: Discussionmentioning

confidence: 98%

Severe coronavirus disease 2019 pulmonary disease in very low birth weight preterm babies

Randad¹,

Bishnoi²,

Sakhare³

et al. 2021

Indian J Child Health

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Severe coronavirus disease 2019 (COVID-19) in neonates is considered a rarity due to vertical transmission and most of the affected babies are asymptomatic. Here, we describe two severe cases of very low birth weight (VLBW) preterm babies in sick newborn care unit (SNCU) due to horizontal transmission. Case 1 describes a VLBW preterm baby (29 weeks) weighing 1300 g who was undergoing care in SNCU. He developed classical symptoms of cold in the form of nasal congestion with mild rhinorrhea, fever, and cough followed by severe prolonged hypoxia with full recovery. Case 2 describes another VLBW preterm (27.3 weeks) weighing 1175 g who was suffering from severe progressive hypoxia around same time. He was initially responsive to oxygen therapy but succumbed to refractory hypoxia later on. We conclude that severe COVID-19 pulmonary disease can occur in few unfortunate VLBW preterm neonates

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Clinical Profile of SARS-CoV-2 Infected Neonates From a Tertiary Government Hospital in Mumbai, India

Cited by 26 publications

References 11 publications

Symptomatic neonatal SARS-CoV-2 infection in a tertiary care teaching hospital: an observational prospective study

Symptomatic neonatal SARS-CoV-2 infection in a tertiary care teaching hospital: an observational prospective study

Study of perinatal transmission of SARS-CoV-2 in a Mexican public hospital

Severe coronavirus disease 2019 pulmonary disease in very low birth weight preterm babies

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