Clinical Profile of Subclinical Hypothyroidism:A Retrospective Study

Shetty, Meenakshi; Adiraju, Krishna Prasad; Modugu, Nageswar Rao

doi:10.19056/ijmdsjssmes/2017/v6i2/149899

Cited by 1 publication

(4 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SNAP amplitudes and Conduction velocity were significantly reduced(p<0.05) in cases diagnosed as hypothyroidism as compared to controls in median (77%), sural (70%) and ulnar nerves (33%). Similar results were also observed by other studies (14,15) . Disturbed myelin synthesis during acute hypothyroidism may be the cause for demyelinating peripheral neuropathy in hypothyroid patients.…”

Section: Discussionsupporting

confidence: 93%

“…Occurrence of neuropathy was more common in female patients 80.95% as compared to male patients 19.05%. Similar results were also seen in studies conducted by other researchers (1,8,15) . Neuropathy was more common with duration of disease 1-5 years (47.62%) and obesity (52.38%) but these findings were not statistically significant (P = 0.60,0.45,0.61 and 0.29) respectively.…”

Section: Discussionsupporting

confidence: 92%

“…Similar results were also observed by Karne and Shetty et.al. (8,15) The increased weight in cases of hypothyroidism would be due to accumulation of mucopolysaccharides, hyaluronic acid and chondroitin sulphate in the interstitial spaces. Those spaces being hydrophilic nature, retain water along with them resulting in weight gain.…”

Section: Discussionmentioning

confidence: 99%

“…There are studies which reported primary axonal degeneration while some reported demyelination as the predominant feature of neuropathy in hypothyroidism (8,15) . In our study we got mixed type of peripheral neuropathy.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Nerve Conduction Study in Early Diagnosed Cases of Hypothyroidism in Central India

2020

IJFMT

View full text Add to dashboard Cite

Thyroid gland has multiple effects on the neuromuscular system and brain, its dysfunction is associated with characteristic symptoms and signs with functional alterations in many organs and systems. Thyroid disease may cause signs and symptoms of neuromuscular dysfunction. Hypothyroidism has been associated with the clinical features of proximal muscle weakness, mononeuropathy and sensorimotor polyneuropathy.Nerve conduction studies (NCS) are useful adjunct to the clinical examination of the peripheral nervous system as it is helpful to test speed of signals through a nerve. They help to delineate the extent and distribution of the neural lesion and distinguish two major categories of peripheral nerve disease demyelination and axonal degeneration. Present cross sectional studywas conducted at Central Neurophysiology Laboratory in tertiary care teaching hospital, J.N.M.C, Sawangi (M), Wardha catering to rural population of central India to assess the nerve conduction in early diagnosed hypothyroid patients. Total twenty seven patients; 20-50yrs of age were screened for nerve conduction.In our study we got mixed type of peripheral neuropathy. Out of 27 patients with age 18-30 yrs-1(16.67%), 31-40 yrs-13(61.90%) and 41-50 yrs -7 (33.3 %) had abnormal NCS. Occurrence of neuropathy was more common in female patients 80.95% as compared to male patients 19.05%.Sensory nerve action potential (SNAP) amplitudes and conduction velocity were significantly reduced (p<0.05) in cases diagnosed as hypothyroidism in median (77%), sural (70%) and ulnar nerves (33%)as compared to controls.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations