Clinical profiles and trend analysis of newly diagnosed lung cancer in a tertiary care hospital of East China during 2011–2015

Abstract

Background: More than one-third of lung cancer worldwide occurring in China. However, the clinical profiles of lung cancer patients in the mainland of China are rarely reported and largely unknown. The Results: From 2011 to 2015, aggregately 5,779 patients, including 3,719 males and 2,060 females, were diagnosed as lung cancer. The major histologic subtypes of lung cancer were adenocarcinoma (ADC, 60.0%), squamous cell carcinoma (SCC, 25.6%), small cell lung cancer (SCLC, 8.5%), large cell carcinoma (0.6%), adenosquamous carcinoma (1%), other non-small cell carcinoma (1.6%) and unclassified or rare carcinoma (2.8%). ADC proportion of female was much higher than that of male. A higher proportion of advanced stage (stage IIIB, IV) of lung cancer existed in patients who were admitted to hospital due to respiratory or cancer related symptoms (RCRS) than those without RCRS. Smoking rate in male patients reached 80.2%, while it was only 2.7% in females. EGFR mutation existed in 66% of female and 37% of male patients with ADC.Conclusions: This study demonstrates the clinicopathologic characteristics of lung cancer patients from East China, including histologic composition, staging proportion, smoking prevalence and gene mutation status. During the past 5 years, the proportion of ADC has increased gradually whereas SCC decreased.

Analysis of the clinicopathological characteristics and their trends among patients with lung cancer undergoing surgery in a tertiary cancer hospital of north China during 2000–2013

“…Globally, the incidence of lung adenocarcinoma (ADC) has exceeded that of squamous cell carcinoma (SQ), the proportion of lung SQ cases in men has dropped significantly, and the proportion of lung ADC cases in women continues to rise (1,2,(7)(8)(9). These findings are consistent with studies conducted in China (10)(11)(12)(13)(14)(15)(16). The epidemiological characteristics of lung cancer changes according to time, geographical location, and population subsets.…”

Alteration of Gut Microbiome in Lung Cancer Patients

“…There are estimated 1.82 million new cases of lung cancer globally, which constitutes nearly 13% of all newly diagnosed cancer cases annually (2). More than one-third of lung cancer worldwide occurring in China, where 733,000 new cases of lung cancer are diagnosed, and about 591,000 Chinese people died from it each year (3-4). Better understanding of factors and pathways involved in lung cancer is urgently needed to improve treatment strategies.…”

BRAF-Mutated Non-Small Cell Lung Cancer: Current Treatment Status and Future Perspective

“…Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer mortality in China ( 1 ). Lung cancer could be divided into non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC); of these, approximately 60% of NSCLC were adenocarcinoma ( 2 ). Generally, about 80% of lung adenocarcinoma harbors driver mutations in east Asians ( 3 ).…”