Clinical profiles, scope and general findings of the Western Sydney First Episode Psychosis Project

Harris, Anthony; Brennan, John; Anderson, Jean; Taylor, Anne; Sanbrook, Mark; Fitzgerald, Dianne; Lucas, Sara; Redoblado-Hodge, Antoinette; Gomes, Lavier; Gordon, Evian

doi:10.1111/j.1440-1614.2005.01517.x

Cited by 20 publications

(22 citation statements)

References 34 publications

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“…Forty-one patients experiencing their first episode of schizophrenia were recruited for the baseline condition as part of the Western Sydney, Australia, First Episode Psychosis project, a multimodal project investigating the clinical, neuroanatomical, neuropsychological and psychophysiological profiles of young people in western Sydney, Australia, who were experiencing their first episode of psychosis (17). A stringent criterion for first-episode status was employed whereby all patients were recruited within 3 months of their first presentation to mental health services with psychotic symptoms (defined as hallucinations, delusions and/or formal thought disorder), although some patients had previously presented with symptoms of anxiety and depression that were not judged to be psychotic at the time.…”

Section: Subjectsmentioning

confidence: 99%

Volumetric White Matter Abnormalities in First-Episode Schizophrenia: A Longitudinal, Tensor-Based Morphometry Study

Whitford

Grieve²,

Farrow³

et al. 2007

AJP

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These results indicate that patients with schizophrenia exhibit white matter abnormalities at the time of their first presentation of psychotic symptoms to mental health services and that these abnormalities degenerate further over the initial years of illness. Given the role that white matter plays in neural communication, the authors suggest that these white matter abnormalities may be a cause of the dysfunctional neural connectivity that has been proposed to underlie the symptoms of schizophrenia.

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Section: Subjectsmentioning

confidence: 99%

Volumetric White Matter Abnormalities in First-Episode Schizophrenia: A Longitudinal, Tensor-Based Morphometry Study

Whitford

Grieve²,

Farrow³

et al. 2007

AJP

Self Cite

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“…First-episode psychosis (FEP), the first presentation of psychotic symptoms, usually occurs in adolescence, a time of great change and upheaval (Harris et al 2005;Mackrell & Lavender 2004). The effect on the sufferer ('the patient') and their family and carers can be immense, with patients often confused, scared, depressed, socially isolated, and devastated by the disruption to their lives and goals (Kilkku et al 2003;.…”

Section: Introductionmentioning

confidence: 99%

First‐episode psychosis: A literature review

Reed

2008

Int J Mental Health Nurs

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This paper reports on a literature review of the impacts of first-episode psychosis on both the patient and their family and carers. The discussion focuses on the effects on the patient experiencing psychotic symptoms for the first time, including disruption to their environment, social connectedness, and future plans. Patients experiencing these symptoms can experience fear, distress, and isolation. Many of these patients are also at greater risk to themselves and others. The family and carers witnessing this psychosis may experience fear, guilt, and often carry the emotional and physical burden of care. Early intervention and treatment are crucial to potentially achieving better clinical outcomes, and to alleviating the psychological impact on patients and their families. The nurse's role in the treatment of the patient experiencing first-episode psychosis is to facilitate early intervention through recognition of symptoms and ongoing assessment, work to reduce a patient's risks, manage treatments, and work with the patient to reduce the risk of relapse.

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“…However, as the distribution of DUP is positively skewed, the mean DUP is not an accurate measure of central tendency 5 . Hence, many authors also report the median DUP while others have chosen not to report the mean DUP at all 4,10 . Median DUP also has its limitations, as it is influenced by the number of patients with a very short DUP, only provides a minimum value for the DUP of patients in the second half of a sample, and may not reflect the rate at which the second half of patients present for treatment.…”

Section: Introductionmentioning

confidence: 99%