Clinical progress in the two years following a course of exclusive enteral nutrition in 109 paediatric patients with Crohn's disease

Abstract

SUMMARY BackgroundExclusive enteral nutrition (EEN) is an effective first line treatment for active paediatric Crohn's disease (CD).

Repeated exclusive enteral nutrition in the treatment of paediatric Crohn's disease: predictors of efficacy and outcome

“…Despite the convincing results regarding immediate benefits of nutritional treatment, duration of remission is poorly studied. In accordance with reports from other centres, [17][18][19] we observed relapses within 1 year in approximately two-thirds of patients following each course of EEN. The high relapse rate occurred in spite of early introduction of immunomodulatory therapy with azathioprine.…”

“…Remission rates ranging from 57% to 80% were reported by other retrospective studies evaluating a consecutive course of EEN and compare favourably to our rates. 7,14,17 Our data support the efficacy of repeated nutritional therapy for active CD, regardless of disease phenotype. Despite the convincing results regarding immediate benefits of nutritional treatment, duration of remission is poorly studied.…”

Time to Relapse in Children with Crohn’s Disease Treated with Azathioprine and Nutritional Therapy or Corticosteroids

“…Recently, the work of Cameron et al [15] suggested that EEN may improve weight and BMI Z scores, but not height Z scores in agreement with previously published data [16]. To date, only three published studies have compared the long-term outcome of induction strategies of EEN and CS in newly diagnosed children with CD [17][18][19].…”

A multicentre Study of Nutrition Risk Assessment in Adult Patients with Inflammatory Bowel Disease Attending Outpatient Clinics

“…In a pooled analysis of 1,698 population-based measurement studies with 19.2 million participants in 200 countries, trends of obesity increased markedly from 1975 to 2014 with approximately 25% of the general Greek and UK population classed as obese [17]. In previous research in CD children, the prevalence of undernutrition dropped from 35% at diagnosis to 2% at 24-month follow-up and obesity concomitantly increased [18]. It is also unlikely that our findings are explained by having oversampled patients in remission or with less complicated disease as we enrolled patients attending outpatient clinics due to ongoing disease symptoms or biologic infusion clinics, as indicated by the characteristics of our sample (Table 1).…”