Clinical progression and predictors of death in patients with severe fever with thrombocytopenia syndrome in China

Cui, Ning; Bao, Xiao-lei; Yang, Zhen‐Dong; Lu, Qing‐Bin; Hu, Chunyan; Wang, Liyuan; Wang, Bingjun; Wang, Hongyu; K, Liu; Yuan, Chun; Fan, Xuejuan; Wang, Zhen; Zhang, Lan; Zhang, Xiao-Ai; Hu, Lina; Liu, Wei; Cao, Wu‐Chun

doi:10.1016/j.jcv.2013.10.024

Cited by 59 publications

(46 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies found that age, neurologic manifestations, hemorrhagic signs, thrombocytopenia, and elevations of AST, CK or LDH were related to mortality in patients with SFTS in univariate analyses [5, 24]. Neurologic manifestations, thrombocytopenia, prolongation of aPTT, hypoalbuminemia and hyponatremia were significant prognostic factors in multivariate analyses [6, 21, 25]. In our study, confusion, elevated levels of CRP, and prolonged aPTT were associated with the death of patients with SFTS in the multivariate analysis.…”

Section: Discussionmentioning

confidence: 94%

Severe Fever with Thrombocytopenia Syndrome in South Korea, 2013-2015

et al. 2016

View full text Add to dashboard Cite

BackgroundSevere fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that was recently identified in China, South Korea and Japan. The objective of the study was to evaluate the epidemiologic and clinical characteristics of SFTS in South Korea.Methods/Principal FindingsSFTS is a reportable disease in South Korea. We included all SFTS cases reported to the Korea Centers for Disease Control and Prevention (KCDC) from January 2013 to December 2015. Clinical information was gathered by reviewing medical records, and epidemiologic characteristics were analyzed using both KCDC surveillance data and patient medical records. Risk factors for mortality in patients with SFTS were assessed. A total of 172 SFTS cases were reported during the study period. SFTS occurred throughout the country, except in urban areas. Hilly areas in the eastern and southeastern regions and Jeju island (incidence, 1.26 cases /105 person-years) were the main endemic areas. The yearly incidence increased from 36 cases in 2013 to 81 cases in 2015. Most cases occurred from May to October. The overall case fatality ratio was 32.6%. The clinical progression was similar to the 3 phases reported in China: fever, multi-organ dysfunction, and convalescence. Confusion, elevated C-reactive protein, and prolonged activated partial thromboplastin times were associated with mortality in patients with SFTS. Two outbreaks of nosocomial SFTS transmission were observed.ConclusionsSFTS is an endemic disease in South Korea, with a nationwide distribution and a high case-fatality ratio. Confusion, elevated levels of C-reactive protein, and prolonged activated partial thromboplastin times were associated with mortality in patients with SFTS.

show abstract

Section: Discussionmentioning

confidence: 94%

Severe Fever with Thrombocytopenia Syndrome in South Korea, 2013-2015

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The small number of cases may be a reason for the results reported by Gai et al (10) that did not find any significant relationship between these two factors. Since several other significant prognostic indicators (e.g., cytokine levels, chemokine levels, platelet counts, lactate dehydrogenase [LDH] levels, and aspartate transaminase [AST] levels) have already been reported (9,10,16,17), the combined use of the viral RNA level with these indicators may provide more substantial information that can be used to select the therapeutic strategy and predict patient prognosis.…”

Section: Discussionmentioning

confidence: 99%

Sensitive and Specific PCR Systems for Detection of Both Chinese and Japanese Severe Fever with Thrombocytopenia Syndrome Virus Strains and Prediction of Patient Survival Based on Viral Load

et al. 2014

View full text Add to dashboard Cite

v Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with a high case fatality risk and is caused by the SFTS virus (SFTSV).A retrospective study conducted after the first identification of an SFTS patient in Japan revealed that SFTS is endemic to the region, and the virus exists indigenously in Japan. Since the nucleotide sequence of Japanese SFTSV strains contains considerable differences compared with that of Chinese strains, there is an urgent need to establish a sensitive and specific method capable of detecting the Chinese and Japanese strains of SFTSV. A conventional one-step reverse transcription-PCR (RT-PCR) (cvPCR) method and a quantitative one-step RT-PCR (qPCR) method were developed to detect the SFTSV genome. Both cvPCR and qPCR detected a Chinese SFTSV strain. Forty-one of 108 Japanese patients suspected of having SFTS showed a positive reaction by cvPCR. The results from the samples of 108 Japanese patients determined by the qPCR method were in almost complete agreement with those determined by cvPCR. The analyses of the viral copy number level in the patient blood samples at the acute phase determined by qPCR in association with the patient outcome confirmed that the SFTSV RNA load in the blood of the nonsurviving patients was significantly higher than that of the surviving patients. Therefore, the cvPCR and qPCR methods developed in this study can provide a powerful means for diagnosing SFTS. In addition, the detection of the SFTSV genome level by qPCR in the blood of the patients at the acute phase may serve as an indicator to predict the outcome of SFTS.

show abstract

“…SFTS virus (SFTSV) is a novel Bunyavirus classified as a member of the genus Phlebovirus and identified as the causative agent of SFTS. SFTS is an emerging disease with a high mortality rate, ranging from approximately 12-30% (1-4). The major clinical features are a fever, muscle weakness, gastroenteric symptoms (nausea, vomiting, and diarrhea), thrombocytopenia (platelet count less than 100×10 9 /L), leukopenia, and elevated levels of aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and creatine kinase (CK).…”

Section: Introductionmentioning

confidence: 99%

“…The major clinical features are a fever, muscle weakness, gastroenteric symptoms (nausea, vomiting, and diarrhea), thrombocytopenia (platelet count less than 100×10 9 /L), leukopenia, and elevated levels of aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and creatine kinase (CK). Severe cases suffer from disturbance of consciousness, convulsion, bleeding tendency with disseminated intravascular coagulation (DIC), and multiple organ failure, leading to death (1,2,4,5). …”

Section: Introductionmentioning

confidence: 99%

Hemophagocytic Lymphohistiocytosis in a Fatal Case of Severe Fever with Thrombocytopenia Syndrome

et al. 2017

View full text Add to dashboard Cite

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging disease caused by a novel Bunyavirus with a high mortality rate. We herein report a fatal case of an 86-year-old woman with SFTS complaining of a fever, fatigue, and bicytopenia. Her condition deteriorated with rapid progression of bleeding tendency, disturbance of consciousness, and multiple organ failure leading to death on Day 6 of her illness. The histopathological findings in the autopsy revealed marked infiltration of macrophages with hemophagocytosis in the bone marrow, liver, and spleen leading to a diagnosis of hemophagocytic lymphohistiocytosis (HLH). HLH might be a critical pathogenesis in fatal cases of SFTS.

show abstract

Clinical progression and predictors of death in patients with severe fever with thrombocytopenia syndrome in China

Cited by 59 publications

References 21 publications

Severe Fever with Thrombocytopenia Syndrome in South Korea, 2013-2015

Severe Fever with Thrombocytopenia Syndrome in South Korea, 2013-2015

Sensitive and Specific PCR Systems for Detection of Both Chinese and Japanese Severe Fever with Thrombocytopenia Syndrome Virus Strains and Prediction of Patient Survival Based on Viral Load

Hemophagocytic Lymphohistiocytosis in a Fatal Case of Severe Fever with Thrombocytopenia Syndrome

Contact Info

Product

Resources

About