Clinical Protection During the First Omicron Wave in Unvaccinated, Convalescent US Adults

Quantification of Severe Acute Respiratory Syndrome Coronavirus 2 Binding Antibody Levels To Assess Infection and Vaccine-Induced Immunity Using WHO Standards

“…Anti-RBD Abs are often used as proxy for neutralizing Abs, as they have been shown to be correlated ( 6 – 8 ). Moreover, some assays rely specifically on serum neutralization ( 1 , 19 – 21 ).…”

“…Total blood SARS-CoV-2 IgG antibodies are highly correlated with neutralizing antibody levels following vaccination and/or past infection. If properly standardized ( 6 – 8 ), IgG Abs could be used to make clinical decisions for treatment or prophylaxis in individual patients who may be at high risk for severe disease. There are over 80 SARS-CoV-2 FDA emergency use authorization (EUA)-approved antibody assays to assess total IgG Abs for SARS-CoV-2 ( 5 , 9 ) and additional in-house protocols ( 1 , 10 ).…”