Clinical, psychophysiological, and neurological characteristics of volunteers with impaired smooth pursuit eye movements

Siever, Larry J.; Coursey, Robert D.; Alterman, Ina; Zahn, Ted; Brody, Leslie R.; Bernad, Peter G.; Buchsbaum, Monte S.; Lake, C. Raymond; Murphy, Dennis L.

doi:10.1016/0006-3223(89)90006-1

“…In addition to the general relationship of SPEM abnormalities with schizophrenia and SPD, the association between deviant eye tracking and specific symptoms of these disorders has been studied. Most studies indicate a relationship with negative symptoms of schizophrenia [ 17 - 21 ] and SPD [ 9 , 22 - 24 ], but a relationship with positive symptoms and symptoms related to Liddle's disorganization syndrome [ 25 ] have also been reported [ 5 , 24 , 26 , 27 ]. Similarly, SPEM dysfunction has been found in general population subjects with elevated scores on either positive or negative measures of schizotypy [ 28 - 30 ].…”

Section: Introductionmentioning

confidence: 99%

SPEM dysfunction and general schizotypy as measured by the SSQ: a controlled study

Kampen¹,

Deijen²

2009

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“…College students with high levels of schizotypal personality traits have been found to show poor SPEM quality, whereas nonschizophrenia‐related personality traits are independent of SPEM dysfunction [8,86]. Similarly, Siever and coworkers reported that college students exhibiting SPEM dysfunction were more likely to experience schizotypal symptoms and to have several cognitive and attentional deficits [87], but not affective symptoms [88]. Smooth pursuit eye movement dysfunction has also been associated with high scores on both positive (perceptual aberration) and negative (physical anhedonia) aspects of schizotypy [89,90].…”

Section: Family and High Risk Studies Of Smooth Pursuit Eye Movementmentioning

confidence: 99%

Eye movement dysfunction as a biological marker of risk for schizophrenia

Lee¹,

Williams²

2000

Aust N Z J Psychiatry

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Evidence for the specificity of SPEM dysfunction to diagnosed schizophrenia, as well as to healthy individuals with a genetic vulnerability to schizophrenia, suggests that the SPEM task has efficacy as a test of gene carrier status in schizophrenia, and therefore as a trait marker of risk for schizophrenia. Future studies should seek to explore the relationships between SPEM and other eye movement dysfunctions (antisaccades, express saccades), in view of evidence that some of these dysfunctions also show specificity for schizophrenia.

show abstract

“…College students with high levels of schizotypal personality traits have been found to show poor SPEM quality, whereas nonschizophrenia-related personality traits are independent of SPEM dysfunction [8,86]. Similarly, Siever and coworkers reported that college students exhibiting SPEM dysfunction were more likely to experience schizotypal symptoms and to have several cognitive and attentional deficits [87], but not affective symptoms [88].…”

Section: Family and High Risk Studies Of Smooth Pursuit Eye Movementmentioning

confidence: 99%

Eye Movement Dysfunction as a Biological Marker of Risk for Schizophrenia

Lee

¹

,

Williams

²

2000

Aust N Z J Psychiatry

View full text Add to dashboard Cite

Evidence for the specificity of SPEM dysfunction to diagnosed schizophrenia, as well as to healthy individuals with a genetic vulnerability to schizophrenia, suggests that the SPEM task has efficacy as a test of gene carrier status in schizophrenia, and therefore as a trait marker of risk for schizophrenia. Future studies should seek to explore the relationships between SPEM and other eye movement dysfunctions (antisaccades, express saccades), in view of evidence that some of these dysfunctions also show specificity for schizophrenia.

show abstract

Clinical, psychophysiological, and neurological characteristics of volunteers with impaired smooth pursuit eye movements

Cited by 35 publications

References 48 publications

SPEM dysfunction and general schizotypy as measured by the SSQ: a controlled study

SPEM dysfunction and general schizotypy as measured by the SSQ: a controlled study

Eye movement dysfunction as a biological marker of risk for schizophrenia

Eye Movement Dysfunction as a Biological Marker of Risk for Schizophrenia

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