Clinical radiohypersensitivity screening using radiation‐induced chromosomal aberrations

Jh, Kearsley; Fang, ZM; Clarke, Raymond A.

doi:10.1111/j.1440-1673.1998.tb00497.x

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…The optimal method for determining RHS is not yet known nor is it readily available for routine use in testing for RHS before or after RT. In the aforementioned cases and others 1 the ICA assay has demonstrated its ability to distinguish patients with RHS. The previous suspicion that such cases would primarily consist of AT heterozygotes has not proven to be correct.…”

Section: Discussionmentioning

confidence: 89%

Clinical application of in vitro radiohypersensitivity testing

Christie¹,

Lavin

Tan³

2000

Australasian Radiology

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The cases of two patients who suffered severe late effects of radiotherapy are reported; each tested positive for elevated in vitro radiohypersensitivity (RHS) but negative for the ataxia-telangiectasia mutation. The first patient underwent surgery and postoperative radiotherapy for lung cancer and subsequently developed fatal myelopathy. The second patient underwent triple-modality therapy for cervical cancer and suffered highly symptomatic pelvic fibrosis. The value of the testing was that it increased the confidence in the diagnosis of radiation effects and enabled suitable treatment to proceed. An increasing role for clinical RHS testing is anticipated.

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Section: Discussionmentioning

confidence: 89%

Clinical application of in vitro radiohypersensitivity testing

Christie¹,

Lavin

Tan³

2000

Australasian Radiology

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Fulminant radiation-induced necrosis after stereotactic radiation therapy to the posterior fossa

Tandon¹,

Vollmer²,

New³

et al. 2001

Journal of Neurosurgery

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The problem of radiation-induced necrosis of normal brain surrounding the target area has been a major catalyst for the development of stereotactically focused radiation therapy. According to current opinion, the effects of stereotactic irradiation are confined to the region targeted. The authors present a case in which the administration of a conventional dose of stereotactically focused irradiation for treatment of a pilocytic astrocytoma produced fulminant necrosis that necessitated a combination of intensive surgical and medical management, after which the patient improved over the course of 1 year. Concomitant with his improvement, the initially remarkable findings on magnetic resonance imaging gradually resolved. In this presentation the authors emphasize the need to evaluate alternatives carefully before a decision is made to administer therapeutic irradiation. Furthermore, they explore the roles that target, host, and dosage factors play in hypersensitivity to radiation injury, the detection of these factors before treatment, and the administration of radioprotective agents. With the growing use of stereotactically focused irradiation as a primary treatment modality for a variety of neurosurgical conditions, it is important to be cognizant of its uncommon but potentially lethal side effects. A cooperative multicenter database in which the outcomes and morbidity following stereotactic irradiation are recorded is essential to the detection of relatively uncommon but severe complications such as those observed in this case.

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Clinical radiohypersensitivity screening using radiation‐induced chromosomal aberrations

Cited by 2 publications

References 7 publications

Clinical application of in vitro radiohypersensitivity testing

Clinical application of in vitro radiohypersensitivity testing

Fulminant radiation-induced necrosis after stereotactic radiation therapy to the posterior fossa

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