Clinical randomized trial study of hearing aids effectiveness in association with Ginkgo biloba extract (EGb 761) on tinnitus improvement

Radunz, Camila L.; Okuyama, Cristina Eunice; Branco-Barreiro, Fátima Cristina Alves; Pereira, Regina Mara Silva; Diniz, Susana Nogueira

doi:10.1016/j.bjorl.2019.05.003

Cited by 29 publications

(30 citation statements)

References 40 publications

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“…The sample size (61 patients) is in the range of that observed in previous studies on tinnitus (Morgenstern and Biermann 2002;Lopez-Gonzalez et al 2007;Tziridis et al 2014;Abtahi et al 2017) and higher than in several of them (Rosenberg et al 1998;Arda et al 2003;Cevette et al 2010;Radunz et al 2019). The high dropout rate (52.5%) noted in our study is worth mentioning, resulting in only 29 patients with complete data at the end of follow-up.…”

Section: Discussionmentioning

confidence: 44%

“…This would support the importance of encouraging patients to remain compliant to achieve perceptible improvements. Patients were slightly younger than in most previously published studies (Cevette et al 2010;An and Whitney 2015;Radunz et al 2019) and 88.5% were actively working, with the implications that this bothersome condition can have in productivity. Stress and noises were the most common factors worsening tinnitus, followed by sleepiness and tiredness, and 80% of patients reported problems with night rest.…”

Section: Discussionmentioning

confidence: 61%

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Effectiveness of Tinnitan Duo® in Subjective Tinnitus with Emotional Affectation: A Prospective, Interventional Study

Knäpper

Girauta

Coromina

2021

Journal of Dietary Supplements

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To assess the effectiveness of a food supplement (Tinnitan Duo V R ) containing 5-hydroxytryptophan, Ginkgo biloba, magnesium, melatonin, vitamin B5 and B6, and zinc at improving tinnitus response and intensity. Prospective, single-center interventional study including patients with subjective tinnitus and emotional affectation. The primary endpoint was the change in the Tinnitus Handicap Inventory (THI) total score and the emotional subscale after 3 months of treatment. Secondary endpoints were the change from baseline to month 3 in (1) the Tinnitus Distress Rating (TDR) scale, and (2) in hearing status, and the safety profile of patients throughout the study. Sixtyone patients were included, and 29 completed the study. The THI total score was significantly reduced after 3 months of treatment in the per-protocol (PP, all the patients with no major protocol deviations) and intention-to-treat (ITT) populations (À15.7 and À7.5, respectively; p ¼ 0.001). The emotional subscale score significantly decreased after 3 months of treatment by À5.6 in the PP (p ¼ 0.001) and by À2.6 in the ITT populations (p ¼ 0.001). Perceived tinnitus loudness significantly decreased after 3 months of treatment (p ¼ 0.001). The audiogram showed no significant changes in hearing status after 3 months of treatment. Of the five adverse events (AEs) reported, all were mild or moderate, and three were related to the study treatment (two headaches and one dizziness). This new food supplement was associated with an improved tinnitus-related emotional affectation and with a good safety profile.

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Section: Discussionmentioning

confidence: 44%

Section: Discussionmentioning

confidence: 61%

Effectiveness of Tinnitan Duo® in Subjective Tinnitus with Emotional Affectation: A Prospective, Interventional Study

Knäpper

Girauta

Coromina

2021

Journal of Dietary Supplements

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“…Primary objective of the included RCTs is the evaluation of specific therapeutic approaches; seventeen of them focus on transcranial magnetic stimulation (TMS) [ 28 , 33 , 41 , 42 , 44 , 45 , 48 , 54 , 67 , 71 , 72 , 76 , 79 , 82 , 85 , 89 , 90 , 91 ], four on acupuncture as monotherapy [ 25 , 51 , 53 , 66 ], more than ten on cognitive behavioral treatment, relaxation and mindfulness [ 20 , 21 , 23 , 26 , 35 , 40 , 47 , 61 , 65 , 68 , 69 , 70 , 75 , 81 , 92 ], seven on provision of hearing aids [ 38 , 41 , 63 , 84 , 87 , 93 , 94 ], 8 on sound therapy [ 24 , 39 , 55 , 60 , 86 , 95 , 96 , 97 ], two on electrical stimulation [ 29 , …”

Section: Resultsmentioning

confidence: 99%

Methodological Aspects of Randomized Controlled Trials for Tinnitus: A Systematic Review and How a Decision Support System Could Overcome Barriers

Kikidis

Vassou

Schlee

et al. 2021

JCM

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Although a wide range of tinnitus management interventions is currently under research and a variety of therapeutic interventions have already been applied in clinical practice, no optimal and universal tinnitus treatment has been reached yet. This fact is to some extent a consequence of the high heterogeneity of the methodologies used in tinnitus related clinical studies. In this manuscript, we have identified, summarized, and critically appraised tinnitus-related randomized clinical trials since 2010, aiming at systematically mapping the research conducted in this area. The results of our analysis of the 73 included randomized clinical trials provide important insight on the identification of limitations of previous works, methodological pitfalls or gaps in current knowledge, a prerequisite for the adequate interpretation of current literature and execution of future studies.

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“…Looking through studies on Ginkgo biloba, we found contrary treatment effects on tinnitus, and a Cochrane review concluded that there was limited evidence to support the effectiveness for patients whose primary complaint was tinnitus [160]. This might be due to a lack of standard usage, a lack of optimal doses, and a lack of standard methodological measurements of efficacy [149,[161][162][163][164]. The efficacy of tinnitus is likely to be the mixture of multiple ingredients, which might not be conducive to guiding the treatment and avoiding adverse effects.…”

Section: Herbal Medicinesmentioning

confidence: 94%

Auditory Neural Plasticity in Tinnitus Mechanisms and Management

Wang

Tang

et al. 2020

Neural Plasticity

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Tinnitus, which is the perception of sound in the absence of a corresponding external acoustic stimulus, including change of hearing and neural plasticity, has become an increasingly important ailment affecting the daily life of a considerable proportion of the population and causing significant burdens for both the affected individuals and society as a whole. Here, we briefly review the epidemiology and classification of tinnitus, and the currently available treatments are discussed in terms of the available evidence for their mechanisms and efficacy. The conclusion drawn from the available evidence is that there is no specific medication for tinnitus treatment at present, and tinnitus management might provide better solutions. Therapeutic interventions for tinnitus should be based on a comprehensive understanding of the etiology and features of individual cases of tinnitus, and more high quality and large-scale research studies are urgently needed to develop more efficacious medications.

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Clinical randomized trial study of hearing aids effectiveness in association with Ginkgo biloba extract (EGb 761) on tinnitus improvement

Cited by 29 publications

References 40 publications

Effectiveness of Tinnitan Duo® in Subjective Tinnitus with Emotional Affectation: A Prospective, Interventional Study

Effectiveness of Tinnitan Duo® in Subjective Tinnitus with Emotional Affectation: A Prospective, Interventional Study

Methodological Aspects of Randomized Controlled Trials for Tinnitus: A Systematic Review and How a Decision Support System Could Overcome Barriers

Auditory Neural Plasticity in Tinnitus Mechanisms and Management

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