2021
DOI: 10.12659/aot.932249
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Clinical Rationale for a Routine Testing Schedule Using Donor-Derived Cell-Free DNA After Kidney Transplantation

Abstract: Kidney transplant recipients require meticulous clinical and laboratory surveillance to monitor allograft health. Conventional biomarkers, including serum creatinine and proteinuria, are lagging indicators of allograft injury, often rising only after significant and potentially irreversible damage has occurred. Immunosuppressive medication levels can be followed, but their utility is largely limited to guiding dosing changes or assessing adherence. Kidney biopsy, the criterion standard for the diagnosis and ch… Show more

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Cited by 4 publications
(1 citation statement)
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“…10 A similar routine testing schedule for dd-cfDNA has recently been proposed. 46 In addition, testing is indicated when graft damage is suspected and 7-10 days after immunosuppressive drug dosage changes. No testing should be performed within 12 hours after biopsy.…”
Section: Clinical Validity Of Dd-cfdna Assaysmentioning
confidence: 99%
“…10 A similar routine testing schedule for dd-cfDNA has recently been proposed. 46 In addition, testing is indicated when graft damage is suspected and 7-10 days after immunosuppressive drug dosage changes. No testing should be performed within 12 hours after biopsy.…”
Section: Clinical Validity Of Dd-cfdna Assaysmentioning
confidence: 99%