Clinical recurrence of prostatic ductal adenocarcinoma in the anterior urethra

Haller, Britt; Yao, Henry Han‐I; Christidis, Daniel; Chee, Justin; Bishop, Conrad

doi:10.1177/2051415820921312

Cited by 2 publications

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“…NEPC tends to metastasize to bone, lung, and liver, and urethra or bladder metastasis has not been reported [ 1 , 2 ]. Isolated metastasis or recurrence of PC in the intra-urinary tract is extremely rare, with only 15 cases reported previously [ 5 – 19 ] (Table 1 ); five had an origin in the prostatic ductal adenocarcinoma (PDC) and most of the rest were from adenocarcinomas with lower Gleason scores. On the other hand, in a study of 282 patients with secondary bladder neoplasms, 19% had PC-related secondary urinary bladder tumors [ 20 ], and 39% had urinary bladder metastases at autopsy [ 21 ], but the majority showed bladder-neck invasion.…”

Section: Discussionmentioning

confidence: 99%

Multiple metastases of androgen indifferent prostate cancer in the urinary tract: two case reports and a literature review

et al. 2022

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Background Prostate cancer (PC) is mainly known to metastasize to bone, lung and liver, but isolated metastases of prostate cancer, including ductal carcinoma, in the urinary tract are very rare. We describe two patients with nodular masses in the urinary tract (the anterior urethra or the urinary bladder) that were found on cystoscopy during treatment of castration-resistant prostate cancer. Case presentation In both cases, the pathological diagnosis from transurethral tumor resection showed that they were androgen indifferent prostate cancer (AIPC), including aggressive variant prostate cancer (AVPC) in Case 1 and treatment-induced neuroendocrine differentiation prostate cancer (NEPC) in Case 2. In Case 1, Loss of genetic heterozygosity (LOH) of BRCA2 and gene amplification of KRAS was identified from the urethra polyps. In Case 2, homozygous deletion was observed in PTEN, and LOH without mutation was observed in RB1. Conclusion These are the first reports of two cases of urinary tract metastasis of AIPC.

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