Clinical relevance of 13 cytokine gene polymorphisms in Chinese major trauma patients

Gu, Wei; Zhou, Jian; Jiang, Dongpo; Zhang, Lianyang; Du, Debin; Hu, Ping; Chen, Kehong; Q, Liu; Wang, Zhengguo; Jiang, Jianxin

doi:10.1007/s00134-010-1797-5

Cited by 35 publications

(45 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Single nucleotide polymorphisms (SNPs) in inflammatory cytokine genes such as those coding for TNF and LTA have been extensively evaluated in adults [12][13][14][15][16][17], providing good markers for severity in adult sepsis. A recent meta-analysis has confirmed an increased risk of sepsis in carriers of the A allele for the TNF-308 G > A SNP [6] and AA genotype for LTA + 252A > G SNP [7].…”

Section: Introductionmentioning

confidence: 99%

Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) single nucleotide polymorphisms: Importance in ARDS in septic pediatric critically ill patients

et al. 2012

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) single nucleotide polymorphisms: Importance in ARDS in septic pediatric critically ill patients

et al. 2012

View full text Add to dashboard Cite

“…Single-nucleotide polymorphisms of nine cytokine genes (out of 13) were associated with ex vivo cytokine production by LPS-stimulated leukocytes or risk of development of sepsis in a cohort of trauma patients [39]. A relationship between IL-6, IL-10 and the responsiveness to an ACTH stimulation test were also reported by Kwon et al [40], strongly confirming an interference between the inflammatory response and the neuro-endocrine pathway.…”

Section: Sepsis Mediators Genetic Predisposition To Sepsismentioning

confidence: 72%

Year in review in Intensive Care Medicine 2010: I. Acute renal failure, outcome, risk assessment and ICU performance, sepsis, neuro intensive care and experimentals

et al. 2011

View full text Add to dashboard Cite

“…Only two studies [15,17] with high quality containing 193 cases and 193 controls evaluated the association of the IL-1A-889 polymorphism (rs1800587) with sepsis risk. In overall comparison, a significant association was observed for allelic effect (OR = 1.47, 95% CI = 1.01-2.13, P = 0.04).…”

Section: Resultsmentioning

confidence: 99%

“…Seven studies [12-15,17,34] totaling 745 cases and 750 controls were identified in order to investigate the association between IL-1B-511 polymorphism (rs16944) and sepsis risk. Overall, the results showed no associations under any genetic model.…”

Section: Resultsmentioning

confidence: 99%

Associations between interleukin-1 gene polymorphisms and sepsis risk: a meta-analysis

et al. 2014

Self Cite

View full text Add to dashboard Cite

BackgroundPrevious epidemiological studies have presented conflicting evidence regarding associations between interleukin-1 (IL-1) polymorphisms and sepsis susceptibility. We have performed a meta-analysis to evaluate possible associations between IL-1 polymorphisms and sepsis risk.MethodsEligible literature was retrieved from PubMed, Embase and Web of Knowledge databases until Jun 15, 2013. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using random-effects model in the overall and subgroup analysis based on ethnicity, sepsis severity and quality score.ResultsEighteen studies addressing five IL-1 polymorphisms were included in this meta-analysis. For IL-1A-889 (rs1800587) polymorphism, significant association was observed in overall comparison for allelic effect (OR = 1.47, 95% CI = 1.01-2.13, P = 0.04). There were no significant associations between either IL-1B-511 (rs16944) or IL-1B-31 (rs1143627) and sepsis susceptibility in overall or subgroup analyses. For IL-1B + 3594 (rs143634) polymorphism, genotype TT decreased sepsis risk in overall analysis (OR = 0.59, 95% CI = 0.36-0.97, P = 0.04), as well as in Caucasian (OR = 0.57, 95% CI = 0.34-0.95, P = 0.03) and sepsis (OR = 0.55, 95% CI = 0.31-0.97, P = 0.04) subgroup analysis. For IL-1RN VNTR polymorphism, significant association was observed in overall comparison for allelic effect (OR = 1.40, 95% CI = 1.01-1.95, P = 0.04). Furthermore, the effect sizes of IL-1RN VNTR on sepsis risk increased with disease severity (septic shock OR > severe sepsis OR > sepsis OR).ConclusionsOur meta-analysis indicated that IL-1A-889, IL-1B + 3954 and IL-1RN VNTR might be associated with sepsis susceptibility. However, further studies with larger sample sizes and from homogenous populations would be necessary to validate these findings.

show abstract

Clinical relevance of 13 cytokine gene polymorphisms in Chinese major trauma patients

Abstract: Polymorphisms of IL-1beta/-1470, IL-1beta/-511, IL-1beta/-31, IL-4/-589, IL-6/-572, IL-8/-251, IL-10/-819, and TNFalpha/-308 are susceptibility loci for the development of sepsis and organ dysfunction in major trauma patients.

Cited by 35 publications

References 15 publications

Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) single nucleotide polymorphisms: Importance in ARDS in septic pediatric critically ill patients

Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) single nucleotide polymorphisms: Importance in ARDS in septic pediatric critically ill patients

Year in review in Intensive Care Medicine 2010: I. Acute renal failure, outcome, risk assessment and ICU performance, sepsis, neuro intensive care and experimentals

Associations between interleukin-1 gene polymorphisms and sepsis risk: a meta-analysis

Contact Info

Product

Resources

About