Clinical Relevance of Cytokines, Chemokines and Adhesion Molecules in Systemic Vasculitis

Kasama, Tsuyoshi; Takahashi, Ryo; Wakabayashi, Kuninobu; Miwa, Yusuke

doi:10.5772/19737

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2020

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“…CXCL10 or IP-10 is a member of the CXC subtype of the chemokine superfamily and is expressed in astrocytes, glial cells, endothelial cells, macrophages, T cells, neutrophils, dendritic cells, keratinocytes, fibroblasts and hepatocytes (Kasama et al, 2011;Vazirinejad et al, 2014;Iwanowski et al, 2017). Its role in the pathogenesis of MS is based on chemoattracting Th1 to CNS (Dufour et al, 2002;Sørensen et al, 2002;Iwanowski et al, 2017).…”

Section: Cxcl10mentioning

confidence: 99%

Investigating the Causal Effect of Brain Expression of CCL2, NFKB1, MAPK14, TNFRSF1A, CXCL10 Genes on Multiple Sclerosis: A Two-Sample Mendelian Randomization Approach

Fazia

Nova

Gentilini

et al. 2020

Front. Bioeng. Biotechnol.

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Causal Genes in Multiple Sclerosis a direct positive causal effect for CCL2. Since in general we observed a different magnitude for the gene specific causal effect we hypothesize that in cerebellum and medulla the effect of each gene expression is direct but also mediated by the others. These results confirm the importance of the involvement of NF-κB signaling pathway in brain tissue for the development of the disease and improve our understanding in the pathogenesis of MS.

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