Clinical Relevance of MMP and TIMP Measurements in Cancer Tissue

Bashir, Omer; Cao, Jian; Zucker, Stanley

doi:10.1002/9783527649327.ch14

Cited by 2 publications

(4 citation statements)

References 83 publications

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“…Normally, TIMPs levels are in excess compared to MMPs levels in extracellular fluids and tissues, thus limiting their activity to focal peri-cellular sites. As previously mentioned, TIMPs are known for their inhibitory activity towards MMPs, nonetheless, it has been shown that the activation of MMP-2 is associated with a low concentration of TIMP-2 coupled with MMP-14 in the cell membrane [12].…”

Section: Endogenous Mmp Inhibitorsmentioning

confidence: 97%

“…Although MMPs are generally considered as pro-oncogenic proteins, some MMPs, such as MMP-8, may have anti-tumor properties. Indeed, in different experimental models the neutrophil collagenase, MMP-8 showed anti-tumoral properties suppressing cell proliferation and the formation of metastases [12]. As described for MMP-1, also MMP-13 protein expression increased during the invasive processes of some tumors, including melanoma [41].…”

Section: Collagenasesmentioning

confidence: 99%

“…The different structures characterizing the various MMPs allow the accomplishment of multiple functions influencing several processes like cell behavior, apoptosis and cell proliferation. Oncological studies have shown that MMPs play several functions favoring tumor progression through the degradation of surrounding tissues, the modulation of growth factors and membrane receptors, as well as inflammatory proteins, adhesion molecules and chemo-attractive proteins [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Functional Roles of Matrix Metalloproteinases and Their Inhibitors in Melanoma

Napoli

Scuderi

Gattuso

et al. 2020

Cells

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The extracellular matrix (ECM) plays an important role in the regulation of the tissue microenvironment and in the maintenance of cellular homeostasis. Several proteins with a proteolytic activity toward several ECM components are involved in the regulation and remodeling of the ECM. Among these, Matrix Metalloproteinases (MMPs) are a class of peptidase able to remodel the ECM by favoring the tumor invasive processes. Of these peptidases, MMP-9 is the most involved in the development of cancer, including that of melanoma. Dysregulations of the MAPKs and PI3K/Akt signaling pathways can lead to an aberrant overexpression of MMP-9. Even ncRNAs are implicated in the aberrant production of MMP-9 protein, as well as other proteins responsible for the activation or inhibition of MMP-9, such as Osteopontin and Tissue Inhibitors of Metalloproteinases. Currently, there are different therapeutic approaches for melanoma, including targeted therapies and immunotherapies. However, no biomarkers are available for the prediction of the therapeutic response. In this context, several studies have tried to understand the diagnostic, prognostic and therapeutic potential of MMP-9 in melanoma patients by performing clinical trials with synthetic MMPs inhibitors. Therefore, MMP-9 may be considered a promising molecule for the management of melanoma patients due to its role as a biomarker and therapeutic target.

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Section: Endogenous Mmp Inhibitorsmentioning

confidence: 97%

Section: Collagenasesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Functional Roles of Matrix Metalloproteinases and Their Inhibitors in Melanoma

Napoli

Scuderi

Gattuso

et al. 2020

Cells

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“…The numerous structures that characterize MMPs allow them to perform multiple roles that influence various processes such as cell behavior, apoptosis, and cell proliferation. MMPs have been found to promote tumor progression by degrading surrounding tissues, modulating growth factors and membrane receptors, as well as inflammatory proteins, adhesion molecules, and chemo-attractive proteins, according to oncological studies [110][111][112]. MMPs are also involved in the alteration of the ECM of the skin.…”

Section: Matrix Metalloproteinasesmentioning

confidence: 99%

Role of Biomarkers in the Integrated Management of Melanoma

Naik¹

2021

Disease Markers

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Melanoma, which is an aggressive skin cancer, is currently the fifth and seventh most common cancer in men and women, respectively. The American Cancer Society reported that approximately 106,110 new cases of melanoma were diagnosed in the United States in 2021, with 7,180 people dying from the disease. This information could facilitate the early detection of possible metastatic lesions and the development of novel therapeutic techniques for melanoma. Additionally, early detection of malignant melanoma remains an objective of melanoma research. Recently, melanoma treatment has substantially improved, given the availability of targeted treatments and immunotherapy. These developments have highlighted the significance of identifying biomarkers for prognosis and predicting therapy response. Biomarkers included tissue protein expression, circulating DNA detection, and genetic alterations in cancer cells. Improved diagnostic and prognostic biomarkers are becoming increasingly relevant in melanoma treatment, with the development of newer and more targeted treatments. Here, the author discusses the aspects of biomarkers in the real-time management of patients with melanoma.

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Clinical Relevance of MMP and TIMP Measurements in Cancer Tissue

Cited by 2 publications

References 83 publications

Functional Roles of Matrix Metalloproteinases and Their Inhibitors in Melanoma

Functional Roles of Matrix Metalloproteinases and Their Inhibitors in Melanoma

Role of Biomarkers in the Integrated Management of Melanoma

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