Clinical relevance of plasma homocysteine levels in Taiwanese patients with coronary artery disease

Abstract

Homocysteine (Hcy) has recently been considered as a risk factor for cardiovascular disease. Coronary artery disease (CAD) is the third most common cause of mortality in Taiwan. The objective of our present study is to delineate the relationship between the plasma Hcy level and CAD in Taiwanese using an improved enzymatic method. Blood samples were collected from 86 CAD patients, which include 38 patients with acute coronary syndrome (ACS) and 48 patients with stable CAD, and 89 controls. Plasma Hcy levels were measured by HPLC and enzymatic methods. Plasma Hcy levels were 8.27 +/- 1.74, 8.50 +/-1.88 and 11.76 +/- 4.58 muM in normal controls, patients with stable CAD and those with ACS, respectively. Plasma Hcy levels were elevated in the cohort of ACS patients, as compared with those of normal controls or patients with stable CAD. Within the CAD group, patients with the highest quartile Hcy level (10.18-23.73 muM) had a significantly higher odd ratio for ACS, as compared with those with the lowest quartile Hcy level after multivariate adjustment. Plasma Hcy concentration can be used as an independent risk factor of ACS, particularly for those with a history of CAD. Moreover, our improved enzymatic assay can be automated for large-scale screening of high-risk cohorts.

Impact of Homocysteine Level on Long-term Cardiovascular Outcomes in Patients after Coronary Artery Stenting

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Permselectivity of Electrodeposited Polydopamine/Graphene Composite for Voltammetric Determination of Dopamine

“…Therefore, dopamine plays a critical role in clinically valuable diagnosing. Selective detection of DA is challenging due to the main interferences, AA and UA, with orders of magnitude higher concentrations . Conventional selective analysis methods include UV‐vis spectrophotometry, fluorometric method and high‐performance liquid chromatography (HLPC) separation‐detection method .…”

“…Conventional selective analysis methods include UV‐vis spectrophotometry, fluorometric method and high‐performance liquid chromatography (HLPC) separation‐detection method . Compared with methods described above, electrochemical method attracts tremendous scientists due to its simplicity, efficiency and sensitivity .…”

The Relationship between Hyperhomocysteinemia, Haemostatic Factors and Acute Coronary Syndrome in Southeastern Turkey: A Prospective, Comparative Study

“…However, mild to moderate elevations in homocysteine levels were reported recently to be risk factors for atherosclerosis and thrombosis. Moderate elevations at homocysteine levels were shown to be associated with an increase the risk for coronary artery disease in many studies [5][6][7][8][9]. Homocysteine provides a suitable backThe Relationship between Hyperhomocysteinemia, Haemostatic Factors and Acute Coronary Syndrome in 273 Southeastern Turkey: A Prospective, Comparative Study ground for atherosclerosis by impairing the mechanisms of coagulation-fibrinolysis, endothelial functions and proliferation of smooth muscle cells.…”