Clinical relevance of resistant strains of Helicobacter pylori: a review of current data

Mégraud, Françis; Doermann, Henry-Pierre

doi:10.1136/gut.43.2008.s61

Cited by 95 publications

(89 citation statements)

References 30 publications

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“…Metronidazole resistance was the first to be described (11,12) and clarithromycin resistance was found to be the most important cause of eradication failure (13). The primary resistance to macrolides in Western countries varies from 2 to 12%.…”

Section: Introductionmentioning

confidence: 99%

Moxifloxacin-Based Triple Therapy Versus Clarithromycin-Based Triple Therapy for First-Line Treatment of Helicobacter pylori Infection: A Meta-Analysis of Randomized Controlled Trials

Wang

Yang

et al. 2009

Intern. Med.

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Background Moxifloxacin-based (RR, 1.13; 95% CI, 1.01, 1.27; P=0.04). There were no statistically significant difference in the overall side effects (RR, 0.61; 95% CI, 0.25, 1.48; P<0.28). Conclusions Moxifloxacin-based triple therapy is more effective and does not increase the incidence of overall side effects compared to clarithromycin-based triple therapy in the treatment of H. pylori infection.

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Section: Introductionmentioning

confidence: 99%

Moxifloxacin-Based Triple Therapy Versus Clarithromycin-Based Triple Therapy for First-Line Treatment of Helicobacter pylori Infection: A Meta-Analysis of Randomized Controlled Trials

Wang

Yang

et al. 2009

Intern. Med.

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“…However, the increasing use of these antibiotics causes the development of clinical isolates of H. pylori resistant to commonly used antibiotics. Resistance to clarithromycin or metronidazole has been described (Huang and Hunt, 1997;Megraud and Doermann, 1998). Therefore, development of new antimicrobial agents against drug resistant H. pylori is needed.…”

Section: Introductionmentioning

confidence: 99%

In vitro anti‐Helicobacter pylori activity of diallyl sulphides and protocatechuic acid

Liu

Hsu

Yin

2007

Phytotherapy Research

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The in vitro inhibitory effects of diallyl disulphide (DADS), diallyl trisulphide (DAT), roselle calyx extract and protocatechuic acid (PA) on the growth of Helicobacter pylori (15 susceptible, 11 clarithromycin-resistant and 9 metronidazole-resistant strains) were studied. The inhibition zone was determined after each agent had been heated at 25, 60, 100°C for 60 min. The minimal inhibitory concentration (MIC) of each agent was determined by the tube dilution assay. The results showed that heat treatment did not affect the anti-H. pylori activity of DADS, DAT, roselle calyx extract and PA, and the MIC values of these agents against test H. pylori strains were in the range 8 -64 mg/L. The time-kill study assay for DAT and PA at 1× × × × × MIC was monitored in Muller Hinton broth supplemented with 10% horse blood or mice stomach homogenate. Both DAT and PA inhibited the growth of all test H. pylori in broth and mice stomach homogenate ( p < < < < < 0.05); however, the inhibitory effects of these two agents were less in mice stomach homogenate than in broth (p < < < < < 0.05). DAT at 4, 6, 8, 10, 12, 14 mg/L and PA at 8, 16, 24, 32, 40, 48 mg/L were used for urease activity assay. These two agents significantly reduced urease activity of test H. pylori strains (p < < < < < 0.05), in which DAT and PA at 1× × × × × MIC reduced the urease activity of H. pylori to 70% and 40%, respectively. These agents, based on their lower MIC values and heat tolerance, might be useful in the prevention or therapy of H. pylori.

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“…] lymphoma (Blaser, 1990;Marshall, 1994). Infection with H. pylori can be effectively treated by the combination of a proton pump inhibitor with multiple antibiotics but although the bacteria can be eradicated in up to 90% of patients side effects, poor compliance and resistance to the antibiotics used are common causes of treatment failure (Megraud and Doermann, 1998;de Boer and Borody, 2000).…”

mentioning

confidence: 99%

Quantitative real-time PCR for the clinical detection of Helicobacter pylori

et al. 2007

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Accurate diagnosis of Helicobacter pylori infection is very important in both clinical practice and research. We evaluated the sensitivity of real-time PCR (RT-PCR) for the detection and quantification of Helicobacter pylori using DNA from 91 human gastric biopsy samples divided into three groups: 46 biopsies from untreated patients who according to the references methods were considered H. pylori-negative (group A); 35 biopsies from patients previously treated against H. pylori and considered to be cured by "gold standard" tests (group B); and 10 biopsies from patients H. pylori-positive by all available methods (group C). The sensitivity of the RT-PCR assay was higher than that of standard methods. Of the 81 patients considered to be uninfected according to the references methods, 16 were H. pylori-positive by PCR, 10 of which were patients who had received H. pylori eradication therapy and 6 were untreated patients. Based on these findings we recommend that RT-PCR should be use in addition to standard methods in clinical studies to monitor the results of H. pylori eradication therapy.

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Clinical relevance of resistant strains of Helicobacter pylori: a review of current data

Cited by 95 publications

References 30 publications

Moxifloxacin-Based Triple Therapy Versus Clarithromycin-Based Triple Therapy for First-Line Treatment of Helicobacter pylori Infection: A Meta-Analysis of Randomized Controlled Trials

Moxifloxacin-Based Triple Therapy Versus Clarithromycin-Based Triple Therapy for First-Line Treatment of Helicobacter pylori Infection: A Meta-Analysis of Randomized Controlled Trials

In vitro anti‐Helicobacter pylori activity of diallyl sulphides and protocatechuic acid

Quantitative real-time PCR for the clinical detection of Helicobacter pylori

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