Clinical relevance of semaphorin-3F in patients with prostate cancer

Abstract

Purpose: To identify prognosis predictors for patients with prostate cancer (PCa).
 
 Methods: Four independent PCa microarray datasets (GSE32448, GSE16560, GSE79957 and GSE17951) were reanalyzed to characterize the expression of semaphorin-3F (SEMA3F) gene between PCa patients and normal prostate tissues and the correlation between SEMA3F expression and the age, tumor/nodes/metastasis (TNM) staging, Gleason Grade Group, prostate-specific antigen level and overall survival of PCa patients. Gene set enrichment analysis was applied to investigate the potential relevant mechanisms regarding the expression of SEMA3F and the proliferation of PCa cells.
 
 Results: The level of SEMA3F was significantly higher in normal prostate tissues compared with that in PCa cells (P

The Role of Semaphorins in Cancers With Special Focus on Urological Malignancies

“…Sema3F has been found to be decreased in cancer tissue compared to healthy prostate [41]. Beuten et al investigated polymorphisms in sem-a3B and sema3F in prostate cancer in regard to patients' ethnicity.…”