Clinical relevance of the utilization of vital Lugol’s iodine staining in detection and diagnosis of oral cancer and dysplasia

Elimairi, I.; Altay, Mehmet Ali; Abdoun, Omer; Elimairi, A.; Tozoglu, Sinan; Baur, Dale A.; Quereshy, Faisal A.

doi:10.1007/s00784-016-1925-x

Cited by 12 publications

(13 citation statements)

References 19 publications

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“…Lugol iodine staining test is currently used for intraoperative assessment of head and neck cancer in the attempt to diagnose the disease as early as possible, and provide the best therapeutic option for every patient [18,19].…”

Section: Resultsmentioning

confidence: 99%

Lugol Iodine Staining Test in Early Detection of Head and Neck Cancer

Stefan¹,

Lostun²,

Lostun³

2017

Rev. Chim.

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Head and neck cancer represents 3% of malignancies, and it is associated with high mortality due to advanced stage diagnosis. In early stages, the symptomatology can either be absent or be very common, misleading the patient who often ignores it. Early diagnosis of head and neck neoplasia is essential for a favorable long-term outcome. Lately new in vivo examination techniques were developed, and older ones have been improved. Today, in vivo staining techniques are an important tool in the diagnostic of head and neck cancer. Lugol iodine staining method provides valuable information concerning the tumor, allowing the surgeon to differentiate premalignant and malignant lesions.

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Section: Resultsmentioning

confidence: 99%

Lugol Iodine Staining Test in Early Detection of Head and Neck Cancer

Stefan¹,

Lostun²,

Lostun³

2017

Rev. Chim.

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“…In the literature different authors have used different concentrations of lugol iodine solution. The most frequent concentrations found are 1%; 3% and 10% [16,20,21], but other concentrations were reported as well: 1.5, 2, 5% [22][23][24][25]. We are using 3% lugol iodine solution with good results in staining the oral cavity tissue structures.…”

Section: Resultsmentioning

confidence: 99%

Lugol Iodine Staining Test in Assessing Disease Free Margins in Tonsillar Cancer

Stefan¹,

Lostun²,

Lostun³

2017

Rev. Chim.

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The carcinoma of the tonsil represents 10-15% of the total of malignant tumors in the oral cavity, having a predilection for males and the great majority is represented by squamous cell carcinomas. In order to improve the long term results of oncologic treatment for patients with tonsillar malignancies early diagnosis and disease free margins during surgery are mandatory. These can be obtained using lugol iodine staining during resection surgery for malignant tumors of the tonsil. This method has been shown to be effective, easy to use, cheap and safe.

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“…In OSCC, CIS, and low- and high-grade OED, little glycogen is present in the granule cell layer, resulting in iodine unstained (IU) areas [ 12 , 27 ]. However, IS cannot be used for patients with iodine allergy, and the technique is invasive [ 28 ]. IS is applicable for movable mucosae such as the tongue, oral floor, buccal mucosa, and soft palate, but is difficult to use on keratinized mucosa such as the gingiva and hard palate [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…IS is applicable for movable mucosae such as the tongue, oral floor, buccal mucosa, and soft palate, but is difficult to use on keratinized mucosa such as the gingiva and hard palate [ 10 ]. It was reported that 53.1% and 21.4% of patients feel discomfort and pain, respectively, with IS [ 28 ]. According to reports [ 12 , 27 , 28 , 29 ], the sensitivity and specificity for detection oral cancer are 56.0% and 46.8% [ 29 ], and 88.5 and 51.6% [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Non-Invasive Early Detection of Oral Cancers Using Fluorescence Visualization with Optical Instruments

Morikawa

Shibahara

Nomura

et al. 2020

Cancers

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Background: Oral cancer screening is important for early detection and early treatment, which help improve survival rates. Biopsy is the gold standard for a definitive diagnosis but is invasive and painful, while fluorescence visualization is non-invasive, convenient, and real-time, and examinations can be repeated using optical instruments. The purpose of this study was to clarify the usefulness of fluorescence visualization in oral cancer screening. Methods: A total of 502 patients, who were examined using fluorescence visualization with optical instruments in our hospitals between 2014 and 2019, were enrolled in this study. The final diagnosis was performed by pathological examination. Fluorescence visualization was analyzed using subjective and objective evaluations. Results: Subjective evaluations for detecting oral cancer offered 96.8% sensitivity and 48.4% specificity. Regarding the objective evaluations, sensitivity and specificity were 43.7% and 84.6% for mean green value, 55.2% and 67.0% for median green value, 82.0% and 44.2% for coefficient of variation of value, 59.6% and 45.3% for skewness, and 85.1% and 75.8% for value ratio. For the sub-analysis of oral cancer, all factors on objective and subjective evaluation showed no significant difference. Conclusions: Fluorescence visualization with subjective and objective evaluation is useful for oral cancer screening.

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Clinical relevance of the utilization of vital Lugol’s iodine staining in detection and diagnosis of oral cancer and dysplasia

Abstract: Lugol's iodine staining can effectively be used in detection of the dysplastic and malignant superficial lesions of the oral epithelium.

Cited by 12 publications

References 19 publications

Lugol Iodine Staining Test in Early Detection of Head and Neck Cancer

Lugol Iodine Staining Test in Early Detection of Head and Neck Cancer

Lugol Iodine Staining Test in Assessing Disease Free Margins in Tonsillar Cancer

Non-Invasive Early Detection of Oral Cancers Using Fluorescence Visualization with Optical Instruments

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