Clinical report: contrast enhancement of tumor perfusion as a guidance for biopsy

Bang, N; Nielsen, Michael Bachmann; Vejborg, Ilse; Mogensen, Anne Mellon

doi:10.1016/s0929-8266(00)00108-7

Cited by 33 publications

(29 citation statements)

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“…There have been three previous studies on the use of CEUS to aid in the biopsy of hepatic focal lesions. Bang et al [10] reported the first case in which they used CEUS to identify the nonnecrotic portion as an adequate biopsy site within a large neurofibrosarcoma. They slowly injected (1 mL/s) a firstgeneration contrast agent in order to sustain the contrast enhancement during the biopsy procedure, as the unstable microbubbles were rapidly destroyed with the colour Doppler mode they used.…”

Section: Discussionmentioning

confidence: 99%

“…This technique has been introduced to help in guiding radiofrequency ablation of hepatic tumours [8,9]. However, not much attention has been paid to the use of CEUS as a method of real-time guidance for biopsy of focal hepatic lesions [10,11]. To our knowledge, no prospective study has been conducted to assess the usefulness of realtime CEUS guidance for biopsy of focal hepatic lesions.…”

Section: Introductionmentioning

confidence: 99%

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Real-time contrast-enhanced ultrasound-guided biopsy of focal hepatic lesions not localised on B-mode ultrasound

et al. 2010

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Real-time contrast-enhanced ultrasound-guided biopsy of focal hepatic lesions not localised on B-mode ultrasound

et al. 2010

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“…Previously, this problem has been avoided by performing multiple biopsies from the center of the lesion to the edge, having a cytopathologist present during biopsy, or performing repeated biopsies. However, the occurrence rate of complications may be increased with those methods (9,10).…”

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confidence: 99%

“…Tumor tissue, identified by the presence of vascularity, can be reliably visualized under CEUS. CEUS-guided biopsy increases the diagnostic rate by 10% and decreases the false negative rate, particularly in large tumors with areas of necrosis (10,12,15).…”

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confidence: 99%

Contrast-enhanced US-guided percutaneous biopsy of anterior mediastinal lesions

Mao²,

Ping³

et al. 2017

Diagn Interv Radiol

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A nterior mediastinal tumors are common in clinical settings. Common lesions include inflammatory vs. neoplastic lesions, benign vs. malignant lesions, and primary vs. metastatic lesions. Among these, lymphomas are medically treatable, thymomas are surgically treatable, and metastatic carcinomas are nonresectable (1). Primary mediastinal tumors represent only about 3% of the tumors within the chest wall. Metastatic carcinoma and non-Hodgkin's lymphoma are among common anterior mediastinal tumors. The rates of nonsurgical tumors such as lymphoma are higher than the rates of surgical diseases such as thymomas (2). Some anterior mediastinal tumors such as nonseminomatous germ cell tumors, thymic carcinomas, seminomas, lymphomas, and thymomas are quite similar in medical imaging appearance, but are quite different in treatment strategy; early and precise histopathologic diagnosis of anterior mediastinal lesions is essential for correct therapeutic decision, and remains an interesting diagnostic challenge (3).Several biopsy techniques and approaches have been previously described and are available to obtain specimens of anterior mediastinal lesions, including percutaneous image-guided core needle biopsy, parasternal anterior mediastinotomy, endoscopic ultrasonography (US)-guided biopsy, video-assisted thoracoscopic surgery, cervical mediastinoscopy, and open surgical procedures (1). Most of those procedures require intubation and general anesthesia. Open biopsy is associated with morbidity, chance of pleural dissemination, and poor long-term results. For these reasons, surgically strategies are not suitable for anterior mediastinum lesions (4).In general, US-guided percutaneous core needle biopsy is the first diagnostic choice because it is a minimally invasive, safe, and cost-effective procedure. I N T E R V E N T I O N A L R A D I O LO G Y O R I G I N A L A R T I C L E PURPOSEWe aimed to explore the value of contrast-enhanced ultrasonography (CEUS) in guidance of percutaneous biopsy of anterior mediastinal lesions. METHODSNinety patients with solitary anterior mediastinal lesions (55 males, 35 females; mean age, 46±4 years) were included. Patients were randomly divided into CEUS group (n=45) and conventional ultrasonography (US) group (n=45). Real-time US-guided core needle (16 G) percutaneous biopsies were performed in all lesions. The display of internal mammary arteries, internal necrosis, and active areas were recorded and compared. Biopsy success rate and diagnostic accuracy were compared between the two groups. RESULTSDisplay rate of unenhanced internal necrosis was higher in the CEUS group than in the US group (88.9% vs. 46.7%, P = 0.041). With real-time CEUS guidance, internal mammary arteries were effectively displayed and avoided during biopsies in 68.9% of the lesions (31/45). Of the lesions, 88.9% (80/90) were histologically proven, including 13 benign lesions and 67 malignancies. There was a significant difference in the rate of successful puncture attempts between the two groups (P = 0.041). CEUS gro...

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“…In some cases, a continuous infusion may be the better choice while in other cases the procedure may be performed without a second contrast injection if the perfusion conditions are adequately demonstrated with the first CEUS to allow for a standard ultrasound guided procedure. CEUS-guided biopsy has been reported to increase the diagnostic accuracy rate by up to 10 % either by directing the biopsy towards contrast-enhanced -and thus viable -tissue inside the tumour and thereby avoiding sampling of necrotic material, or by identifying previously not-visualised lesions more accessible for biopsy [4,[68][69][70][71][72]. Furthermore, CEUS may visualise active bleeding, hemobilia or segmental liver infarction.…”

Section: Ceus-guided Interventionsmentioning

confidence: 99%

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Clinical report: contrast enhancement of tumor perfusion as a guidance for biopsy

Cited by 33 publications

References 4 publications

Real-time contrast-enhanced ultrasound-guided biopsy of focal hepatic lesions not localised on B-mode ultrasound

Real-time contrast-enhanced ultrasound-guided biopsy of focal hepatic lesions not localised on B-mode ultrasound

Contrast-enhanced US-guided percutaneous biopsy of anterior mediastinal lesions

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