Clinical Report of 28 Patients with Sheehan's Syndrome

A Case of Postpartum Hypopituitarism Accompanied by Cushing's Syndrome as a Result of an Adrenocortical Carcinoma

“…One of the causes of hypopituitarism is the postpartum ischemic pituitary necrosis, which is called Sheehan's syndrome [1][2][3]. If a patient describes early menopause with the symptoms and clinical findings of hypothyroidism, this syndrome must be thought and a detailed obstetrical history must be taken to obtain some clues of postpartum pituitary necrosis.…”

“…Partial or total empty sella is a characteristic finding of Sheehan's syndrome [1,2]. The reasons for secondary empty sella are surgical treatment, radiotherapy, spontaneous infarction of pituitary tumors, Sheehan's syndrome, lymphocytic hypophysitis, levothyroxine therapy in patient with primary hypothyroidism and bromocriptine therapy in prolactinoma [7,8].…”

“…The typical course of Sheehan's syndrome is the appearance of GH and PRL deficiency, followed by gonadotropin deficiency, and then, thyrotropin deficiency and finally, corticotropin deficiency [1,2,6]. The severity of pituitary damage determines the timing of the onset and the magnitude of pituitary failure.…”

“…SHEEHAN'S syndrome occurs as a result of ischemic pituitary necrosis due to severe postpartum hemorrhage and is characterized by various degrees of hypopituitarism [1,2]. Sheehan's syndrome is a rare postpartum complication of pregnancy with better obstetric care in developed countries.…”

“…Sheehan's syndrome is a rare postpartum complication of pregnancy with better obstetric care in developed countries. Acute hypopituitarism may occur immediately after delivery or different degrees of pituitary failure may develop step by step over a long period [2,3].…”