Clinical Research Involving Children: Registration, Completeness, and Publication

Abstract

Results are unavailable for more than half of the studies involving children, revealing a substantial publication bias. Registration and posting of results on ClinicalTrials.gov should be mandatory for all studies involving children.

Publicación de trabajos presentados en los Encuentros Nacionales de Investigación Pediátrica de la Sociedad Argentina de Pediatría: factores involucrados

“…9 C o n t a r c o n f i n a n c i a m i e n t o e s t u v o significativamente asociado a la publicación, y no influyeron ni el diseño ni el tipo de presentación, aunque, en este último caso (presentación oral), la ausencia de significación puede deberse a una falta de potencia (p= 0,06). Kleine-Konig 6 y Shamliyan 10 encontraron que los trabajos experimentales y aquellos que se presentaban en forma oral se publicaban más que los observacionales. También Canosa 4 encontró que la presentación oral se asociaba a mayor posibilidad de publicación.…”

Publication of abstracts presented at the National Pediatric Research Meetings of the Argentine Society of Pediatrics: Related factors

“…9 Having received funding was significantly associated with publishing, but design and type of presentation were not; notwithstanding this, for type of presentation (oral), lack of significance may have been due to lack of power (p = 0.06). Kleine-Konig 6 and Shamliyan 10 observed that experimental studies and abstracts presented orally had more chances of publication than observational ones. Canosa 4 also observed that oral presentations were associated with greater chances of publication.…”

Availability of results from clinical research: Failing policy efforts

“…Less than half of the NIH-funded registered trials are published in a peer-reviewed journal within 30 months of trial completion [17]. Only 29% of completed registered studies involving children and 53% of NIH-funded trials have been published [18].…”

“…Previous research used time-consuming manual searchers of the publications in various subsets of registered studies (i.e., by source of funding [17], study participants [18], and specific health conditions) [19]. In contrast, this paper examines result availability from all studies registered with ClinicalTrials.gov to answer the question: Do existing policies in research registration, publication, and indexing guarantee access to the results?…”