Clinical research of rolling manipulation in treating knee osteoarthritis

Oriental medicine as collaborating treatments with conventional treatments for knee osteoarthritis: A PRISMA-compliant systematic review and meta-analysis

“…A total of 23 studies were selected and analyzed (Table 1). Among the 23 studies, Cao 2013, [23] Yang 2012, [25] Miao 2014, [29] Sun 2009, [30] Zhao 2013, [32] and Zhou 2014 [33] had 2 experimental groups and were compared with the conventional treatment. Therefore, they were synthesized by dividing them each into 2 different studies, for example, Miao 2014 (1) and Miao 2014 (2) during the meta-analysis.…”

“…After 2010, 4 articles were published each in 2014 [24,29,33,39] and 2015, [28,34,43,45] one study in 2010 [27] and 2011, [44] 2 studies in 2012 [25,36] and 2019, [40,41] and 3 studies in 2013 [23,26] and 2017. / [37,38,42] Regarding the country of publication, 22 papers (95.7%) were published in China [23][24][25][26][27][28][29][30][32][33][34][35][36][37][38][39][40][41][42][43][44][45] and 1 paper (4.3%) was published in Spain. [31] Except for Vas 2004, [31] all were published in China.…”

“…The total number of patients including the intervention group and control group in each study ranged from a minimum of 58 to a maximum of 152. There were 17 studies with 50 to 100 participants [24][25][26][27][28][30][31][32]34,35,[38][39][40][41][42]44,45] and 6 studies with more than 100 participants. [23,29,33,36,37,43] Conventional treatment, which is the control group of the 23 studies included in this review, can be divided into 2 major categories: drug and injection.…”

“…There were 5 studies (21.7%) in which the conventional treatment was an injection, [23][24][25][26][27] and all of them used sodium hyaluronate. 18 studies (78.3%) used the drug as a control group, [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] all of which used NSAIDs, in specific, celecoxib in 13, [29,30,32,33,[36][37][38][39][40][41][42]44,45] diclofenac in 4, [31,34,35,43] and ibuprofen in 1. [39] The OM treatment used in the intervention group of the study was either used alone or in combination with conventional treatment.…”

“…[39] The OM treatment used in the intervention group of the study was either used alone or in combination with conventional treatment. As mentioned above, 6 studies [23,25,29,30,32,33] have 2 intervention groups making a total of 29 studies when discussing the intervention group. 24 studies (82.8%) used only one OM treatment method, and 5 studies (17.2%) used both OM and conventional treatment.…”