Clinical resolution of generalized lichen amyloidosis with dupilumab: a new alternative therapy

Humeda, Yasmine; Beasley, Jenna; Calder, Kenneth B.

doi:10.5070/d32612051364

Cited by 17 publications

(19 citation statements)

References 13 publications

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“…As expected, LA was the most common subtype of PLCA found in our study group [14]. Almost 30% of our patients had either a history of atopic skin disease or of thyroid disease -a relationship of these pruritic diseases that has been well established [12,[15][16][17][18][19][20].…”

Section: Discussionsupporting

confidence: 60%

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Primary Localized Cutaneous Amyloidosis: A Retrospective Study of an Uncommon Skin Disease in the Largest Tertiary Care Center in Switzerland

et al. 2021

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Background: Primary localized cutaneous amyloidosis (PLCA) is defined by the deposition of amyloid protein in the skin without systemic involvement. There are four subtypes of PLCA: lichen amyloidosis (LA), macular amyloidosis (MA), biphasic amyloidosis (BA), and nodular amyloidosis (NA). PLCA occurs most frequently in Latin Americans and Asians. Treatment is not standardized. Objectives: To identify subtypes, demographic and clinical features and treatment efficacy in patients with histopathologically confirmed PLCA. Materials and Methods: Data of PLCA patients were extracted from the electronic hospital database and included if diagnosis of PLCA was histopathologically confirmed and if sufficient information regarding treatment and follow-up was available. The evaluation of the treatment efficacy was based on a novel score to assess the reduction of itch and skin lesions. Results: In this retrospective, monocentric study, 37 cases of PLCA diagnosed between 2000 and 2020 were included (21 females) with a mean age of 52 years. LA was the most frequent subtype found in 21 patients (56.8%), followed by MA in 10 patients (28%) and BA in 6 patients (16.2%). No cases of NA were included. 22 patients (59.4%) had skin phototype II or III. Regarding treatment, a combination of UVA1 phototherapy with high-potency topical corticosteroids seemed to show the highest efficacy with complete clearance of symptoms in 4 patients (10.8%). A substantial improvement of symptoms was found in 5 patients (12.7%) treated with high-potency topical corticosteroids alone or in combination either with UVA1 or bath PUVA or monotherapy with UVA1 phototherapy or capsaicin (0.075%) cream. Low-/medium-potency topical corticosteroids alone or in combination with UVBnb (311 nm) phototherapy showed a lower efficacy. Conclusion: Our data show that PCLA is a rare disease in central Europe but can also be expected in a predominantly Caucasian population. The best treatment response was achieved with a combination of UVA1 phototherapy and high-potency topical corticosteroids.

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Section: Discussionsupporting

confidence: 60%

“…Chronic scratching is believed to lead to apoptosis of keratinocytes and consecutive amyloid deposition in the dermis [18][19][20]. Therefore, treatment should aim to reduce pruritus as much as possible, as amyloid formation is potentially the end-stage rather than the cause of the skin disease.…”

Section: Discussionmentioning

confidence: 99%

Primary Localized Cutaneous Amyloidosis: A Retrospective Study of an Uncommon Skin Disease in the Largest Tertiary Care Center in Switzerland

et al. 2021

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“…16 Topical corticosteroids are the gold standard therapy for various inflammatory skin diseases. 28 The therapeutic effects of corticosteroids include anti-inflammatory, immunosuppressive, antiproliferative, and vasoconstrictor properties. 29 Very potent topical corticosteroids should be used on thick lesions and in areas other than intertriginous areas.…”

Section: Discussionmentioning

confidence: 99%

Coexistent Lichen Amyloidosis and Acquired Reactive Perforating Collagenosis in Type 2 Diabetes Mellitus and Post-Thyroidectomy Hypothyroidism Due to Papillary Thyroid Carcinoma: A Rare Case

Sutedja¹,

Widjaya²,

Dharmadji³

et al. 2022

IMCRJ

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An abundance of endocrine receptors is expressed on the skin and becomes the target of many hormones. This was associated with various skin diseases that might occur in some endocrine diseases eg, lichen amyloidosis (LA) and acquired reactive perforating collagenosis (ARPC). Here, we report a coexistent LA and ARPC in a 55-year-old woman, characterized with multiple pruritic hyperkeratotic papules and plaques on both arms accompanied by pruritic hyperkeratotic papules and nodules on both legs. She had a history of type 2 diabetes mellitus (DM) and post-thyroidectomy hypothyroidism due to papillary thyroid carcinoma. Histopathological examination revealed amyloid deposition in the papillary dermis corresponding with LA and cup-shaped epidermal depression filled with collagen corresponding with ARPC. The hyperkeratotic papules and nodules flattened in one month after application of 0.05% clobetasol propionate ointment with occlusion on both arms and 0.05% retinoic acid gel on both legs. Hyperkeratotic papules, nodules, and plaques in a patient with a history of endocrine diseases, such as type 2 DM and thyroid disorders should undergo histopathological examination to confirm the diagnosis of skin diseases eg, LA or ARPC.

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“…Emerging biological agents and small molecule agents, such as dupilumab, IL-31 or JAK inhibitors might be the potential therapies for PCA, especially for generalized type. 1 , 7 , 8 …”

Section: Discussionmentioning

confidence: 99%

Lichen Amyloidosis on the Scalp: A Case Report

Li¹,

Huang²,

Du³

et al. 2022

CCID

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Lichen amyloidosis (LA) is one form of primary cutaneous amyloidosis, presented as discrete, lichenoid papules with itching, commonly involving the extensor surfaces of extremities. Scalp involvement is rarely reported in the literature. In this study, we reported a case of LA over the crown and vertex areas of the scalp. The lesions subsided with topical clobetasol propionate/all-trans retinoic acid compound ointment treatment for 2 months and achieved significant improvement.

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Clinical resolution of generalized lichen amyloidosis with dupilumab: a new alternative therapy

Cited by 17 publications

References 13 publications

Primary Localized Cutaneous Amyloidosis: A Retrospective Study of an Uncommon Skin Disease in the Largest Tertiary Care Center in Switzerland

Primary Localized Cutaneous Amyloidosis: A Retrospective Study of an Uncommon Skin Disease in the Largest Tertiary Care Center in Switzerland

Coexistent Lichen Amyloidosis and Acquired Reactive Perforating Collagenosis in Type 2 Diabetes Mellitus and Post-Thyroidectomy Hypothyroidism Due to Papillary Thyroid Carcinoma: A Rare Case

Lichen Amyloidosis on the Scalp: A Case Report

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