Clinical results and prospects for the use of phenosanic acid in patients with focal epilepsy

Бурд, С. Г.; Лебедева, А. В.; Pantina, N.V.; Rubleva, Yu. V.; Пизова, Н. В.; Васильев, С. В.; Белова, А. Н.; Воробьева, О. В.; Emel’yanova, V.V.; Жаднов, В А; Иванова, Н. Е.; Kalinin, Vladimir V.; Kissin, M. Ya.; Котов, С. В.; Maksimova, N. E.; Mihajlov, V.A.; Новиков, А. Е.; Повереннова, И Е; Yamin, M. A.

doi:10.17116/jnevro202112110152

Cited by 7 publications

(1 citation statement)

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“…The introduction of antioxidants—compounds that scavenge free radicals and help living cells maintain their redox status—may help to overcome the side effects caused by organotin [ 13 ]. Indeed, 2,6-Di- tert -butylphenols are known for their antioxidant properties [ 14 ], and they are used in many fields of modern chemistry as polymerization stabilizers [ 15 ], food supplements [ 16 ], and drugs as well [ 17 ]. The introduction of this pendant into the structure of organotin pharmaceuticals may help to attenuate the toxic impact on various cell types and lower the overall cytostatic impact on the living organism [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic and Luminescent Properties of Novel Organotin Complexes with Chelating Antioxidant Ligand

et al. 2022

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A novel polydentate chelating antioxidant ligand and series of organotin complexes on its base were synthesized and characterized by NMR 1H, 13C, 119Sn, IR spectroscopy, X-ray, and elemental analysis. Their antioxidant activity was evaluated in DPPH and NBT-tests, and as lipoxygenase inhibitory activity. It was shown that ligand alone is a radical scavenger, while introducing tin in the structure of the compound significantly decreases its activity. For the ligand alone the ability to strongly suppress the formation of advanced glycation end products (AGEs) was shown, which may be associated with the established antiradical activity. All synthesized compounds appeared to be moderate lipoxygenase inhibitors. The stability of compounds to hydrolysis under different pH was estimated. The ligand undergoes decomposition after about an hour, while organotin complexes on its base demonstrate vast stability, showing signs of decomposition only after 5 h of experimentation. Cytotoxicity of compounds was studied by standard MTT-test, which showed unorthodox results: the ligand itself demonstrated noticeable cytotoxicity while the introduction of organotin moiety either did not affect the toxicity levels or reduced them instead of increasing. Organotin complexes possess luminescence both as powders and DMSO solutions, its quantum yields reaching 67% in DMSO. The combination of luminescence with unique cytotoxic properties allows us to propose the synthesized compounds as perspective theranostic agents.

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