Clinical results of boron neutron capture therapy (BNCT) for glioblastoma

Comparative dosimetry in intracavitary balloon catheter brachytherapy with I-125 and in Cf-252 brachytherapy combined with BNCT for brain tumors

“…Recently, the treatment of 23 patients with BNCT was reported in the study published by Kageji et al, where the mean survival was 19.5 months; and 26.1%, 17.4% and 5.8% of the patients had a survival of two years, three years and five years, respectively. The authors also suggest that the combination of the technique with TMZ would produce better results (29) .…”

A study on the optimum fast neutron flux for Boron Neutron Capture Therapy of deep-seated tumors

“…2009;Savolainen et.al. 2013;Kato et.al, 2004) or deep-seated tumors (Rao et.al, 2004;Kageji, 2011;Yamamoto, 2004;Kawabata, 2009). While a thermal neutron beam (E<1eV) is suitable for treating shallow tumors, the irradiation of epithermal neutron beam (1 eV≤ E ≤ 10 keV) for treatment of deeper tissues is examined in the literature (IAEA-TECDOC, 2001;Kiger III et.al, 2009;Marashi, 2000).…”

A feasibility study of a deuterium–deuterium neutron generator‐based boron neutron capture therapy system for treatment of brain tumors

“…6,7 At present, BNCT treatments have to be carried out at nuclear reactors. 6,8,9 These neutron sources are expensive and complex for most clinical settings, which ultimately limits the number of available BNCT facilities around the world and imposes heavy financial burden on the institutions. Nuclear reactors also have low public acceptability and require complicated licensing procedures.…”