Clinical review: Healing in gastrointestinal anastomoses, Part I

Thompson, Sarah K.; Chang, Eugene; Jobe, Blair A.

doi:10.1002/micr.20197

Cited by 192 publications

(164 citation statements)

References 28 publications

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“…Early anastomotic strength is therefore dependent on the suture-holding capacity of existing collagen until large amounts of new collagen can be synthesized by both fibroblasts and smooth muscle cells. The final phase of healing involves maturation of newly formed anastomosis by the transformation of collagen into thick bundles and contractile units [39] . In the propolis group, the proliferation, activation, and synthesis capacity of fibroblasts were much better than the control group.…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural view of colon anastomosis under propolis effect by transmission electron microscopy

Kılıçoğlu¹,

Kilicoglu²,

Erdemlı³

2008

WJG

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AIM:To evaluate the effect of propolis administration on the healing of colon anastomosis with light and transmission electron microscopes. METHODS: Forty-eight Wistar-Albino female rats were divided into two groups and had colon resection and anastomosis. In group Ⅰ, rats were fed with standard rat chow pre-and postoperatively. The rats in group Ⅱ were fed with standard rat chow and began receiving oral supplementation of propolis 100 mg/kg per day beginning 7 d before the operation and continued until they were sacrificed. Rats were sacrificed 1, 3, 7 and 14 d after operation, and anastomotic bursting pressures measured. After the resection of anastomotic segments, histopathological examination was performed with light and transmission electron microscopes by two blinded histologists and photographed. RESULTS: The colonic bursting pressures of the propolis group were statistically significantly better than the control group. Ultrastructural histopathological analysis of the colon anastomosis revealed that propolis accelerated the phases of the healing process and stimulated mature granulation tissue formation and collagen synthesis of fibroblasts. CONCLUSION: Bursting pressure measurements and ultra structural histopathological evaluation showed that administration of propolis accelerated the healing of colon anastomosis following surgical excision.

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Section: Discussionmentioning

confidence: 99%

Ultrastructural view of colon anastomosis under propolis effect by transmission electron microscopy

Kılıçoğlu¹,

Kilicoglu²,

Erdemlı³

2008

WJG

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“…Cutaneous wound healing is a complex process composed of interdependent and overlapping stages, namely, clot formation, inflammation, proliferation,a n dremodeling [15,16]. The initial postinjury phase is characterized by the formation of a fibrin clot followed by the inflammatory stage (within 1-3 days after injury) which is dominated by immune cells (i.e., neutrophils and macrophages) that destroy bacteria and debride the wound.…”

Section: Introductionmentioning

confidence: 99%

Psychological stress and wound healing in humans: A systematic review and meta-analysis

Walburn

Vedhara

Hankins

et al. 2009

Journal of Psychosomatic Research

284

187

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(2009) Psychological stress and wound healing in humans: a systematic review and meta-analysis. Journal of Psychosomatic Research, 67 (3). pp. [253][254][255][256][257][258][259][260][261][262][263][264][265][266][267][268][269][270][271] This version is available from Sussex Research Online: http://sro.sussex.ac.uk/2232/ This document is made available in accordance with publisher policies and may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the URL above for details on accessing the published version. Copyright and reuse:Sussex Research Online is a digital repository of the research output of the University.Copyright and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable, the material made available in SRO has been checked for eligibility before being made available.Copies of full text items generally can be reproduced, displayed or performed and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. Abstract Objective: The current review aims to synthesize existing knowledge about the relationship between psychological stress and wound healing. Methods: A systematic search strategy was conducted using electronic databases to search for published articles up to the end of October 2007. The reference lists of retrieved articles were inspected for further studies and citation searches were conducted. In addition, a meta-analysis of a subset of studies was conducted to provide a quantitative estimation of the influence of stress on wound healing. Results: Twenty-two papers met the inclusion criteria of the systematic review and a subsample of 11 was included in a meta-analysis. The studies assessed the impact of stress on the healing of a variety of wound types in different contexts, including acute and chronic clinical wounds, experimentally created punch biopsy and blister wounds, and minor damage to the skin caused by tape stripping. Seventeen studies in the systematic review reported that stress was associated with impaired healing or dysregulation of a biomarker related to wound healing. The relationship between stress and wound healing estimated by the meta-analysis was r=−0.42 (95% CI=−0.51 to −0.32) (Pb.01). Conclusion: Attention now needs to be directed towards investigating potential moderators of the relationship, mediating mechanisms underpinning the association, as well as the demonstration of a causal link by the development of experimental interventions in healthy populations.

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“…This is achieved by avoiding large gaps between sutures, and ensuring that all layers of the intestine are included in the stitch (Figure 3). Wound strength is greatly diminished in the first two post-operative days, thus properly placed sutures are essential to provide strength 16,17 . A potential pitfall is inadvertently only including the mucosa as the mucosa can pucker out of the lumen of the transected colon.…”

Section: Discussionmentioning

confidence: 99%

Murine Ileocolic Bowel Resection with Primary Anastomosis

Perry

Borowiec

Dicken

et al. 2014

JoVE

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Intestinal resections are frequently required for treatment of diseases involving the gastrointestinal tract, with Crohn's disease and colon cancer being two common examples. Despite the frequency of these procedures, a significant knowledge gap remains in describing the inherent effects of intestinal resection on host physiology and disease pathophysiology. This article provides detailed instructions for an ileocolic resection with primary end-to-end anastomosis in mice, as well as essential aspects of peri-operative care to maximize post-operative success. When followed closely, this procedure yields a 95% long-term survival rate, no failure to thrive, and minimizes post-operative complications of bowel obstruction and anastomotic leak. The technical challenges of performing the procedure in mice are a barrier to its wide spread use in research. The skills described in this article can be acquired without previous surgical experience. Once mastered, the murine ileocolic resection procedure will provide a reproducible tool for studying the effects of intestinal resection in models of human disease. Video LinkThe video component of this article can be found at

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Clinical review: Healing in gastrointestinal anastomoses, Part I

Cited by 192 publications

References 28 publications

Ultrastructural view of colon anastomosis under propolis effect by transmission electron microscopy

Ultrastructural view of colon anastomosis under propolis effect by transmission electron microscopy

Psychological stress and wound healing in humans: A systematic review and meta-analysis

Murine Ileocolic Bowel Resection with Primary Anastomosis

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