Clinical Review of Histamine2 Receptor Antagonists

A lyophilized aqueous extract of Maytenus ilicifolia leaves inhibits histamine-mediated acid secretion in isolated frog gastric mucosa

“…Cimetidine, a histamine H 2 receptor antagonist, blocked basal acid secretion only when added to the serosal surface of mucosae, the same surface at which histamine stimulated H + secretion. It is well known that cimetidine is a potent anti-ulcerogenic agent since it suppresses gastric secretion of acid and pepsin (Lipsy et al 1990) and scavenges hydroxyl radicals and hydrochloric acid (Ching et al Fig. 4 Effect of increasing concentrations of LAEMIL on acid secretion induced by 100 lM histamine.…”

Radioprotective Effects of Histamine H2 Receptor Antagonists Famotidine and Ranitidine on Gamma-Ray Induced Chromosome Aberration and Micronuclei <i>in vitro</i> in Human Lymphocytes

“…Studies carried out by Lappena et al [18] have shown that Famotidine and Ranitidine as such do not have immunomodulatory role in the body but these drugs are potent oxygen radical scavengers. Ching et al [19] have demonstrated that histamine H2 receptor antagonists such as Famotidine and Ranitidine were good inhibitors of histamine -stimulated gastric acid secretion and also posses the capability for gastric acid suppression and pepsin secretion [4]. These are potent and highly powerful hydroxyl-radical scavengers.…”

“…Histamine H2 receptor antagonist also known as H2 blocker are class of drug which are used to block the action of histamine on parietal cells in stomach thus decreasing acid production by these cells. These drugs are potent scavengers of oxygen radicals, good inhibitors of histamine -stimulated gastric acid secretion, have capability for gastric acid suppression and the pepsin secretion and in addition are potent & highly powerful hydroxyl-radical scavengers [4]. Histamine H2 receptor antagonist such as Cimetidine, Famotidine and Ranitidine are used in the clinical treatment of peptic ulcer.…”

Medications and their effects on sleep

“…Somnolence and lethargy at conventional doses, however, have been documented in the elderly and patients with renal impairment. Slow wave sleep is increased by cimetidine [19,[49][50][51].…”