“…Thus, their for mation can be influenced by factors causing abnormal development of the embryo [17], Particularly, the simian crease has been ob served as a characteristic dermatoglyphic feature in many abnormalities, including Down's syndrome, trisomy 18, trisomy 13, Turner's syndrome and other structural chromosomal aberrations [17], Further more, it has been observed in a variety of other syndromes and abnormalities with an increased frequency, e.g., in premature births, stillbirths, neonatal deaths and con genital anomalies [7], An increased age at delivery, toxemia, hypertension and hy dramnios as well as previous stillbirths in the mothers of infants with simian crease have also been reported [7], Johnson and Opilz [13] observed an association between mental retardation and congenital malfor mations and found that relatively more mothers of children with simian crease had prenatal complications of infection and bleeding. Recently, Dar et al [6] reported a high incidence of simian creases in infants being premature, small for gestational age or who had been exposed to metadone dur ing fetal life.…”