Clinical role of positron emission tomography in oncology

Bomanji, JB; Costa, D. C.; Ell, PJ

doi:10.1016/s1470-2045(00)00257-6

Cited by 249 publications

(120 citation statements)

References 42 publications

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“…PET is regularly used as a functional imaging modality, particularly in the field of oncology (3). Most PET studies depend on the visual qualitative interpretation of whole body images after injection of 18 F-FDG.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of standardized uptake values obtained from 18f fluorodeoxyglucose positron emission tomography/computed tomography imaging performed with 2d and 3D modes in oncological cases

Kocabaş¹,

Yapar²,

Reyhan³

et al. 2012

Diagn Interv Radiol

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NUCLEAR MEDICINEORIGINAL ARTICLE PURPOSE We investigated the usability of standardized uptake values (SUV) obtained from both two-and three-dimensional (2D and 3D) positron-emission tomography and computed tomography (PET-CT) imaging, and compared the images obtained from these techniques in terms of image quality, lesion detectability, and the presence of artifacts. MATERIALS AND METHODSImage data from 100 patients, who had undergone two PET imagings obtained in 2D and 3D mode after a low dose CT, were evaluated prospectively. Subjective analysis of 2D and 3D images was performed by two readers evaluating the following criteria: overall image quality, detectability of each identified lesion, and the presence of artifacts. The lesions recognized by the readers were also analyzed quantitatively by measuring SUV values. RESULTSThere was a significant difference between the SUVs obtained in 2D and 3D modes. Regardless if the first scan was performed in 2D or 3D mode, the values obtained from 3D imaging were significantly lower than those obtained from 2D imaging (mean SUV max was 10.48±7.57 for 2D, and 9.66±6.93 for 3D, P < 0.001). Visual analysis did not reveal significant differences regarding lesion detectability between two modes. CONCLUSIONIn oncological PET-CT applications, SUV values are significantly lower in 3D compared with 2D mode. Thus when serial scanning is needed to evaluate response to therapy in the same patient, the imaging modality should be taken into account and performed with the same method to avoid misinterpretation. Additionally, 3D PET-CT imaging can be used instead of 2D PET-CT due to its shorter scanning time without loss of lesion detectability. F-FDG PET is now routinely used in detecting, staging, and evaluating treatment response of various tumors (1-4). The combination of PET and computed tomography (CT) provides the ability to accurately register the metabolic and molecular aspects of disease with anatomical findings, adding further information to the diagnosis and staging of tumors. PET-CT is a fast growing imaging modality worldwide (2).PET scanners from some vendors can acquire data in both two-dimensional (2D) and three-dimensional (3D) modes, whereas others can only acquire data in 3D mode (5). A shorter scan time and improved efficiency of 18 F-FDG use due to higher sensitivity in the 3D mode could theoretically be the main advantage of 3D acquisition compared to standard 2D (6).There are diverse approaches to assess the amount of 18 F-FDG uptake, though standardized uptake values (SUVs) are widely employed as a semi-quantitative index for tumor uptake (7,8). SUV can be affected by various factors, such as time of acquisition after radiopharmaceutical injection, plasma glucose level, partial volume effect, reconstruction parameters, and attenuation correction methods. In addition, SUV is known to depend on acquisition parameters and region of interest (ROI) selection. Therefore, SUVs may not only change with different modes of acquisition (2D or 3D mode), but also with the u...

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Section: Discussionmentioning

confidence: 99%

“…F-FDG PET is now routinely used in detecting, staging, and evaluating treatment response of various tumors (1)(2)(3)(4). The combination of PET and computed tomography (CT) provides the ability to accurately register the metabolic and molecular aspects of disease with anatomical findings, adding further information to the diagnosis and staging of tumors.…”

mentioning

confidence: 99%

Comparison of standardized uptake values obtained from 18f fluorodeoxyglucose positron emission tomography/computed tomography imaging performed with 2d and 3D modes in oncological cases

Kocabaş¹,

Yapar²,

Reyhan³

et al. 2012

Diagn Interv Radiol

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“…This noninvasive technique that recognizes alterations in cellular glucose metabolism detects the presence of cancer cells by their increased glucose metabolism [1]. In addition to such visual analysis, an often-used semiquantitative parameter, called the standardized uptake value (SUV) assesses the uptake of FDG.…”

Section: Introductionmentioning

confidence: 99%

Gastric cancers with microsatellite instability exhibit high fluorodeoxyglucose uptake on positron emission tomography

et al. 2012

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Background Gastric cancers exhibit various degrees of 18 F-fluorodeoxyglucose (FDG) uptakes on positron emission tomography/computed tomography (PET/CT) imaging. The aim of this study was to evaluate whether FDG uptake in gastric cancer varies according to the microsatellite instability (MSI) status. Methods Consecutive gastric cancer patients who underwent PET/CT imaging and MSI analysis were included in the study. The maximum standardized uptake value (SUV max ) of gastric cancer was assessed using PET/CT imaging. Results Of 131 gastric cancers, 16 exhibited a high incidence of MSI (MSI-H) and 3 exhibited a low incidence of MSI (MSI-L). In 29 subjects who showed no uptake on PET/CT imaging the gastric cancers were all microsatellite stable (MSS). Gastric cancers with MSI were related to age older than 60 years (p = 0.002), cancer volume larger than 10 cm 3 (p = 0.015), and the presence of FDG uptake on PET/CT imaging (p = 0.001). A higher SUV max of gastric cancer was linked to the presence of MSI (p \ 0.001). Conclusion The presence of MSI is related to FDG uptake in gastric cancer. Care should be taken with MSS gastric cancers, because they show lower SUV max on PET/ CT imaging than MSI gastric cancers.

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“…In the field of radiopharmaceuticals production for nuclear medicine and positron emission topography (PET), the introduction of 18F, 79Br, 81Br and 131I by replacement of hydrogen had played a vital role in enhancing the biological significance of tryptamine [19].…”

Section: Halogen Derivativesmentioning

confidence: 99%

Biomedical Significance of Tryptamine: A Review

Kousara¹,

Anjuma²,

Jaleel³

et al. 2017

J Pharmacovigil

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Tryptamine the important psychotropic drug having indole ring has wider biological and pharmaceutical significance. The focus is to see the relevant and recent achievements as neurotransmitter and neuromodulator, vasoconstrictor and vasodilator, antimicrobial and antibacterial, antioxidant and antifungal agents. Tryptamine and its natural and synthetic derivative have been reported for the variety of biological significance in the above mentioned area. This review covers all these aspects in a comprehensive way.

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Clinical role of positron emission tomography in oncology

Cited by 249 publications

References 42 publications

Comparison of standardized uptake values obtained from 18f fluorodeoxyglucose positron emission tomography/computed tomography imaging performed with 2d and 3D modes in oncological cases

Comparison of standardized uptake values obtained from 18f fluorodeoxyglucose positron emission tomography/computed tomography imaging performed with 2d and 3D modes in oncological cases

Gastric cancers with microsatellite instability exhibit high fluorodeoxyglucose uptake on positron emission tomography

Biomedical Significance of Tryptamine: A Review

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