2016
DOI: 10.1016/j.yrtph.2016.05.030
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Clinical safety evaluation of marine oil derived from Calanus finmarchicus

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Cited by 17 publications
(11 citation statements)
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“…The safety of human consumption of wax ester rich oil from copepods ( Calanus finmarchicus ) was studied through clinical trials (randomized, double-blind, placebo-controlled), and long-term consumption (12 months) of 2 g/day did not show any negative effects on hematological and clinical chemistry parameters, including gastrointestinal-related effects [ 87 , 88 ]. Despite a large amount of wax ester, calanus oil has been suggested as a good source of the long-chain polyunsaturated fatty acids (PUFA), eicosapentaenoic acid, and docosahexaenoic acid for humans, and commercial products are available as dietary supplements [ 89 , 90 ].…”
Section: Resultsmentioning
confidence: 99%
“…The safety of human consumption of wax ester rich oil from copepods ( Calanus finmarchicus ) was studied through clinical trials (randomized, double-blind, placebo-controlled), and long-term consumption (12 months) of 2 g/day did not show any negative effects on hematological and clinical chemistry parameters, including gastrointestinal-related effects [ 87 , 88 ]. Despite a large amount of wax ester, calanus oil has been suggested as a good source of the long-chain polyunsaturated fatty acids (PUFA), eicosapentaenoic acid, and docosahexaenoic acid for humans, and commercial products are available as dietary supplements [ 89 , 90 ].…”
Section: Resultsmentioning
confidence: 99%
“…However, other publications have demonstrated that mammals can digest wax esters, at least when consumed in moderate amounts (Hansen and Mead, 1965;Yaron et al, 1982;Gorreta et al, 2002) As reviewed by Hargrove et al (2004), humans are able to hydrolyze the waxes found in a variety of food items and absorb the liberated fatty acids and alcohols. The safety of the oil from Cf for human consumption has been clinically evaluated by Tande et al (2016), and there are no safety concerns regarding this novel marine oil when consumed in recommended amounts of 2g of calanus oil. Parallel to this safety trial ran a study on the bioavailability of EPA and DHA in oil from Cf for human consumption (Cook et al, 2016b).…”
Section: Oil Extracted From Calanus Finmarchicusmentioning
confidence: 99%
“…(2004) , humans are able to hydrolyze the waxes found in a variety of food items and absorb the liberated fatty acids and alcohols. The safety of the oil from Cf for human consumption has been clinically evaluated by Tande et al. (2016) , and there are no safety concerns regarding this novel marine oil when consumed in recommended amounts of 2g of calanus oil.…”
Section: Oil Extracted From Calanus Finmarchicusmentioning
confidence: 99%
“…The participants were advised to consume four capsules daily (2 g CO/day) with plenty of water (at least 200 mL) and a meal to ensure LC n-3 FAs absorption. Tande et al (2016) evaluated the clinical safety of CO (2 g/d) using biochemical and haematological parameters in a randomized, double-blind, placebo-controlled trial. In summary, no adverse effects on human body were observed [23].…”
Section: Study Design and Participantsmentioning
confidence: 99%
“…Tande et al (2016) evaluated the clinical safety of CO (2 g/d) using biochemical and haematological parameters in a randomized, double-blind, placebo-controlled trial. In summary, no adverse effects on human body were observed [23]. Additionally, in the present trial, tolerability was controlled using questionnaires.…”
Section: Study Design and Participantsmentioning
confidence: 99%