Clinical severity of respiratory syncytial virus Group A and B infection in Sydney, Australia

McIntosh, E. David G.; Silva, L. M. De; Oates, R. K.

doi:10.1097/00006454-199310000-00004

Cited by 103 publications

(71 citation statements)

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“…In Australia, McIntosh et al [1993a] also observed a predominance of subgroup A from 1989 to 1991, but no differences in the severity of disease between both subgroups were detected. It was postulated that subgroup A probably prevents further infections with subgroup B.…”

Section: Discussionmentioning

confidence: 83%

Respiratory syncytial virus: Changes in prevalence of subgroups A and B among Argentinian children, 1990-1996

Carballal

Videla

Sequeira³

et al. 2000

J. Med. Virol.

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The frequency of respiratory syncytial virus (RSV) and the distribution of subgroups A and B strains during 7 consecutive years (1990-1996) were examined in two cities of Argentina. Nasopharyngeal aspirates from 1,304 children less than 2 years of age hospitalized with acute lower respiratory infection were studied by indirect immunofluorescence. RSV was detected in 352 cases (26.9%), and the peak activity was observed in midwinter. Subgroup characterization was performed with two monoclonal antibodies against the F protein on nasopharyngeal aspirate smears. Of 195 samples, 174 (89.2%) were identified as subgroup A strains and 21 (10.8%) as subgroup B. Both strains cocirculated during 5 of 7 years studied with subgroup A predominating. Subgroup A occurred at least 8 times as often in all years except for 1994-1995. Children infected by subgroup A were younger than those infected by subgroup B (P < 0.05). The association of subgroup A infection with bronchiolitis and subgroup B with pneumonia was statistically significant (P < 0.03).

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Section: Discussionmentioning

confidence: 83%

Respiratory syncytial virus: Changes in prevalence of subgroups A and B among Argentinian children, 1990-1996

Carballal

Videla

Sequeira³

et al. 2000

J. Med. Virol.

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“…The need for respiratory support seems a reliable indicator of severity. McIntosh et al [1993], in a study of RSV outbreaks during 1989-91, however, found no correlation between strain group and the requirement of oxygen or ventilation. On the other hand, McConnochie et al [1990] and Taylor et al [1989] in analysing illnesses in infants hospitalised during two RSV outbreaks, one of predominantly Subgroup B and one of predominantly Subgroup A strains, suggested that the requirement of oxygen therapy or ventilation was suitable for discriminating between the Salomon et al [1991] in Argentina, found that respiratory rate >50/min.…”

Section: Discussionmentioning

confidence: 92%

“…Published reports disagree as to whether or not there is a difference in the pathogenicity of the two RSV subgroups [Taylor et al, 1989;Monto and Ohmit 1990;Hall et al, 1990;McIntosh et al, 1993;Hornsleth et al, 1998]. If an association between severity of infection and RSV subgroups could be established, the early information about the RSV variant causing the disease might help the clinician to decide on therapy (like Ribavirin treatment), especially in younger infants.…”

Section: Introductionmentioning

confidence: 99%

Clinical and epidemiologic characteristics of respiratory syncytial virus subgroups A and B infections in Santa Fe, Argentina

et al. 2000

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Respiratory Syncytial Virus (RSV) has two major antigenic groups, A and B. The implications of these variants in the epidemiology and pathogenesis of RSV infection are not well defined. This study was undertaken to compare the two RSV subgroups in patients admitted to hospital. Clinical and epidemiologic features of RSV subgroups in children under 30 months of age with proven RSV acute lower respiratory infections were examined during 4 winters from 1993 to 1996 in Santa Fe, Argentina. RSV typing was carried out with monoclonal antibodies in nasopharyngeal cells by indirect immunofluorescence. Of the 177 RSV positive nasopharyngeal aspirates obtained from 1993 to 1996, 85 (48%) were available for typing. Seventy-three (85.9%) specimens were identified as Subgroup A and 12 (14.1%) as Subgroup B. Except in 1993, in which only Subgroup A was detected, both variants circulated throughout the epidemic season. Subgroup A infections produced more severe disease than Subgroup B infections, as assessed by the length of the hospital stay and the use of respiratory support. This difference was age related, being evident in infants 0-6 months old. Patients with Subgroup B infections were also significantly less frequently breast-fed (95% vs. 75% for A and B subgroups, respectively; P = 0.04). It is concluded that the severity of disease in Argentinian patients admitted with acute RSV infections may be associated with Subgroup A strains as determined by a serogrouping method.

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“…It is not apparent why RSV infection in CF infants from Denver and Melbourne should vary so markedly in severity and outcome. Differences in either severity among RSV subtypes 21 or management 22 are unlikely explanations. Reliance upon oropharyngeal, rather than BAL, cultures meant that the infants with lower airway P. aeruginosa infection may not have been identified.…”

Section: Discussionmentioning

confidence: 99%

Severe viral respiratory infections in infants with cystic fibrosis

et al. 1998

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Clinical severity of respiratory syncytial virus Group A and B infection in Sydney, Australia

Cited by 103 publications

References 0 publications

Respiratory syncytial virus: Changes in prevalence of subgroups A and B among Argentinian children, 1990-1996

Respiratory syncytial virus: Changes in prevalence of subgroups A and B among Argentinian children, 1990-1996

Clinical and epidemiologic characteristics of respiratory syncytial virus subgroups A and B infections in Santa Fe, Argentina

Severe viral respiratory infections in infants with cystic fibrosis

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