Clinical short-term results of radiofrequency ablation in primary and secondary liver tumors

Clinical trial of E1B-deleted adenovirus (dl1520) gene therapy for hepatocellular carcinoma

“…7 Hyperthermia resulting from laser beam or radiofrequency heat ablation using cooled -tip needles have been used to provide palliation in these patients. 8,9 Genetic abnormalities seen in HCC tumor cells include inactivation of tumor suppressor genes 10 and activation of oncogenes. 11 The tumor suppressor gene of most interest is p53 that is located on the short arm of chromosome 17 ( 17p13 ).…”

Experimental study of large-volume microwave ablation in the liver (Br J Surg 2002; 89: 1003-1007)

“…Those lesions close to vessels offer the poorest response as a result of conduction and dissipation of heat by the blood flow 2,4 . The histological evidence from patients supports this finding as some viable tumour is present at both intravascular and perivascular areas 4 . Thus, ablation of liver tumours usually requires multiple applications and takes time ranging from 10 to 30 minutes per application, depending on the histological type of the tumour 4 .…”

Letter 1: Randomized clinical trial of specific lactobacillus and fibre supplement to early enteral nutrition in patients with acute pancreatitis (Br J Surg 2002; 89: 1103-1107)

“…In addition, heat is lost from tissue during RFA via conduction and via low-resistance shunting through electrical paths such as blood vessels. Those lesions close to vessels offer the poorest response as a result of conduction and dissipation of heat by the blood flow 2,4 . The histological evidence from patients supports this finding as some viable tumour is present at both intravascular and perivascular areas 4 .…”