2018
DOI: 10.1002/hed.25386
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Clinical significance and peculiarities of succinate dehydrogenase B and hypoxia inducible factor 1α expression in parasympathetic versus sympathetic paragangliomas

Abstract: Background: Succinate dehydrogenase subunit B (SDHB) immunohistochemistry was considered a valuable tool to identify patients with inherited paraganglioma

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Cited by 6 publications
(10 citation statements)
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“…Prior to immunohistochemical analysis in tumor tissues, the specificity of the HIF2α antibody was confirmed by using approaches described in Supplementary Figure S1 . For HIF1α immunohistochemistry, quantification was performed as previously described [ 32 ]. Images were analyzed randomly by 3 of the authors (L.C., A.A., and M.-D.C.) without knowledge of clinicopathological data.…”
Section: Methodsmentioning
confidence: 99%
“…Prior to immunohistochemical analysis in tumor tissues, the specificity of the HIF2α antibody was confirmed by using approaches described in Supplementary Figure S1 . For HIF1α immunohistochemistry, quantification was performed as previously described [ 32 ]. Images were analyzed randomly by 3 of the authors (L.C., A.A., and M.-D.C.) without knowledge of clinicopathological data.…”
Section: Methodsmentioning
confidence: 99%
“…Genetic inactivation of SDH genes can be detected by the loss of SDHB protein immunostaining [36]. Because SDH mutations can also arise at somatic, not germline, levels, we retrieved SDHB immunohistochemical data from our previous reports [32][33][34] in 21 MPPGL samples…”
Section: Low Prevalence Of Pd-l1 Expression and Ctl Tumor Infiltratio...mentioning
confidence: 99%
“…In normoxic conditions, HIF resulted hydroxylated by PHDs at prolines residues allowing its cellular degradation through the ubiquitin-proteasome system ( Figure 2 ). The high oncometabolites concentration prevents the HIF hydroxylation stabilizing it in the active form inducting a pseudohypoxia status characterized by increased angiogenesis and glucose metabolism [ 37 , 145 , 146 , 147 , 148 ]. Independently by HIF mechanism, fumarate and succinate can additionally enhance hypoxia signalling via TETs epigenetic activation [ 149 ] and through ABL1 up-regulation and mTOR pathway [ 150 ].…”
Section: Oncometabolites Mechanism Of Cancer Inductionmentioning
confidence: 99%