Clinical significance and possibilities of therapy of post-stroke depression

Трусова, Н. А.; Левин, О С

doi:10.17116/jnevro201911909260

Cited by 6 publications

(4 citation statements)

References 64 publications

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“…The preclinical study of Xiaoyao Jieyu San was a traditional Chinese medicine consisting of 11 components. By increasing 5-HT in PSD rats, the expression of norepinephrine and Brain-Derived Neurotrophic Factor (BDNF) werereduced, thereby reducing the degree of depression in PSD (Trusova and Levin, 2019).Spikes in glutamate levels in PSD were common, and giving pyruvate to experimental rats had been reported to limit the amount of glutamate to reduce symptoms of anxiety and depression (Pei et al, 2019).Studies had shown that aryl hydrocarbon receptor nuclear translocation protein 2 (ARNT2) could help neurons survive and have neural functions. The effect of ARNT2 in PSD rats may be a therapeutic target for further translational research (Hu et al, 2019;Rice et al, 2022).…”

Section: Group 1: Study Of Risk Factors For Depression After Strokementioning

confidence: 99%

Bibliometric analysis of global research trends in post-stroke depression: hotspots and frontiers

Yang

et al. 2023

Preprint

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Background Post-stroke depression(PSD) is one of the most common complications of stroke which affects recovery and quality of patients’ life adversely. PSD also is a significant source of burden for caregivers. Recently, the number of publications on PSD has been an increasing worldwide that means PSD has attracted more and more attention. Therefore, a more comprehensive understanding of the publications on PSD is now required. The purpose of this paper is to analyze the research status, discover the hotspots and frontiers about PSD. Methods The publications’ raw data was retrieved from the Web of Science Core Collection on September 19, 2022. Impact Factor (IF) and Journal Citation Reports (JCR) segments of the publications were obtained from the Web of Science website. Visualization analysis was performed on CiteSpace and VOSviewer. Results From 2012 to 2022, the number of citations and publications about PSD increased exponentially year by year. Finally, a total of 3268 publications related to PSD were identified. China (867) and the US (738) had the most publications; Capital Med Univ and Univ Melbourne were the most prolific institutions. Ungvari GS and Hackett ML were the most active authors and the most prolific and co-cited, respectively. Journal of stroke cerebrovascular diseases (131 articles) was the highest output. Among the 3268 publications, International journal of stroke had the most citations (43.9 times), Stroke has the most citations (2,990) and the highest H-index value. The citation burst for 8 co-cited references lasts until 2022. Finally, this paper divided the hot spots into four categories: cluster 1 (study on risk factors of PSD), cluster 2 (clinically relevant research on PSD), cluster 3 (mechanisms of PSD), and cluster 4 (the Treatment Study for PSD). Conclusion PSD research is one research main area worldwide. This work demonstrated the knowledge structure and the evolution of the PSD research field and predictdresearches trends through visual analysis. The study of clinical treatment and prevention of PSD will instead of the study of the mechanism in the future. This study provides reference for future research of PSD.

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Section: Group 1: Study Of Risk Factors For Depression After Strokementioning

confidence: 99%

Bibliometric analysis of global research trends in post-stroke depression: hotspots and frontiers

Yang

et al. 2023

Preprint

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“…The intricate etiology of PSD encompasses socio-psychological dynamics, pathophysiological alterations, and myriad other contributory factors. This complexity underpins the prevailing absence of a coherent, efficacious clinical approach towards PSD, often culminating in suboptimal therapeutic outcomes for the afflicted ( Starkstein, Mizrahi & Power, 2008 ; Trusova & Levin, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Nomogram model for predicting the risk of post-stroke depression based on clinical characteristics and DNA methylation

Luo,

Liu,

Liao

et al. 2023

PeerJ

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Objective To construct a comprehensive nomogram model for predicting the risk of post-stroke depression (PSD) by using clinical data that are easily collected in the early stages, and the level of DNA methylation, so as to help doctors and patients prevent the occurrence of PSD as soon as possible. Methods We continuously recruited 226 patients with a history of acute ischemic stroke and followed up for three months. Socio-demographic indicators, vascular-risk factors, and clinical data were collected at admission, and the outcome of depression was evaluated at the third month after stroke. At the same time, a DNA-methylation-related sequencing test was performed on the fasting peripheral blood of the hospitalized patients which was taken the morning after admission. Results A total of 206 samples were randomly divided into training dataset and validation set according to the ratio of 7:3. We screened 24 potentially-predictive factors by Univariate logistic regression and least absolute shrinkage and selection operator (LASSO) regression analysis, and 10 of the factors were found to have predictive ability in the training set. The PSD nomogram model was established based on seven significant variables in multivariate logistic regression. The consistency statistic (C-index) was as high as 0.937, and the area under curve (AUC) in the ROC analysis was 0.933. Replication analysis results in the validation set suggest the C-index was 0.953 and AUC was 0.926. This shows that the model has excellent calibration and differentiating abilities. Conclusion Gender, Rankin score, history of hyperlipidemia, time from onset to hospitalization, location of stroke, National Institutes of Health Stroke scale (NIHSS) score, and the methylation level of the cg02550950 site are all related to the occurrence of PSD. Using this information, we developed a prediction model based on methylation characteristics.

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“…At present, post-stroke depression is mainly treated with antidepressants [9], but it is important to consider any potential side effects, including damage to the heart, gastrointestinal tract, sexual dysfunction, and sleep disturbances [10,11]. The study found that patients taking medications were characterized by a low compliance rate, long reaction time, strong dependence, and large adverse reactions (e.g., headache, nausea, excitement, decreased intellective acuity, loss of memory loss, gain in weight, and metabolic disturbance [12]).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, antidepressants do not fully respond to a large proportion of patients [14]. From the above problems, it can be inferred that poststroke depression is difficult to achieve complete remission by antidepressant treatment alone [9,10].Therefore, combining pharmacological and nonpharmacological therapies is essential. Traditional Chinese acupuncture rehabilitation is an effective nonpharmacological therapy for post-stroke depression because acupuncture has very good results in regulating depression and improving mood and sleep [15].…”

Section: Introductionmentioning

confidence: 99%

Clinical Efficacy and Safety of Acupuncture Rehabilitation for Post-stroke Depression: A Systematic Review and Meta-analysis

et al. 2023

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Objective: The most important and common psychiatric disorders after stroke include post-stroke depression, which can lead to a variety of negative health outcomes. This study was calculated to estimate the security and effectiveness of acupuncture rehabilitation in curative effects for post-stroke depression patients. Methods: As of July 2022, PubMed, Embase, Web of Science, Cochrane Library, and China National Knowledge Infrastructure were searched through electronic databases. Eligibility criteria RCTs evaluate RCTs of acupuncture rehabilitation on treatment events in depressed patients after stroke, compared to a control group. Results: Eight studies were included (n = 16,422). When combined with antidepressant/sham acupuncture efficacy, acupuncture intervention observably reduced HAMD scores (MD= -0.55,95% CI= -1.57 to -0.48, P=0.30, I²= 0%). Meanwhile, acupuncture rehabilitation also reduced BI scores (MD= 1.87,95%CI= -3.77-7.51, P=0.51, I²= 0%) and CGI-S score (MD=0.43,95% CI = 0.06-0.77, P =0.01, I² = 0%) compared with antidepressants / sham acupuncture. Second, the occurrence rate of combined negative events was dramatically lesser in the acupuncture groups, as indicated by the SERS scores (MD= -4.85,95% CI= 5.67 to -4.04, P <0.00001, I² = 0%) of the acupuncture groups and the antidepressant/sham acupuncture groups. Furthermore, the overall clinical outcome was observably better in the acupuncture groups (MD=1.58,95% CI =0.813.09, P =0.18, I² = 0%). Conclusion: Acupuncture rehabilitation intervention for post-stroke depression is safer and more effective than antidepressant/sham acupuncture.

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Clinical significance and possibilities of therapy of post-stroke depression

Cited by 6 publications

References 64 publications

Bibliometric analysis of global research trends in post-stroke depression: hotspots and frontiers

Bibliometric analysis of global research trends in post-stroke depression: hotspots and frontiers

Nomogram model for predicting the risk of post-stroke depression based on clinical characteristics and DNA methylation

Clinical Efficacy and Safety of Acupuncture Rehabilitation for Post-stroke Depression: A Systematic Review and Meta-analysis

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