Clinical significance and prognostic value of circulating B10 cells in colorectal cancer

Abstract

Background: B10 cells, a subset of regulatory B cells, can inhibit antitumor response and thus promote tumor development. This study explored the clinical meaning and prognostic value of circulating B10 cells in colorectal cancer (CRC). Materials and methods:The proportion of B10 cells in peripheral blood in CRC patients and healthy controls was detected by multicolor flow cytometry. Results:The proportion of circulating B10 cells was remarkably elevated in CRC patients compared to normal controls (% of CD19 + B cells; 16.6% (IQR 6.0%) versus 9.0% (IQR 5.7%), p < 0.001). B10 cells proportion was associated with tumor size, depth of invasion, lymph node metastasis, and TNM stage in CRC. Kaplan-Meier analysis indicated that CRC patients with high B10 cells proportion suffered worse overall survival than those with low B10 cells proportion. Multivariate analysis revealed that the proportion of B10 cells was an independent prognostic indicator for CRC patients. Conclusion:Our results indicate that the proportion of circulating B10 cells is an independent prognostic factor for patients with CRC and thus may help guide the clinical decision in CRC.

Circulating immune cells and risk of osteosarcoma: a Mendelian randomization analysis

“…These cells likely contribute to an antitumor immunity effect by producing IL-10 and inducing the generation of immunosuppressive T cells. In some observational studies, both greater infiltration of the tumor tissues by B10 cells and a high proportion of circulating B10 cells could result in a worse prognosis or tumor progression in gastric cancer, colorectal cancer, and cervical cancer ( 38 – 40 ). More than that, it was proposed that immune B cells exhibited a double role in promoting and inhibiting cancer progression depending on their phenotype ( 41 ).…”