Clinical Significance and Prognostic Value of the Expression of LAMP3 in Oral Squamous Cell Carcinoma

Lu, Jun Q.; Ma, Hengcheng; Lian, Shuijin; Huang, Dan; Lian, Min; Zhang, Ye; Huang, Jianfei; Feng, Xingmei

doi:10.1155/2017/1218254

Cited by 9 publications

(10 citation statements)

References 40 publications

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“…In breast cancer, the PERK branch of the UPR increases cell migration upon hypoxic induction through ATF4-mediated induction of lysosomal-associated membrane protein 3 (LAMP3), a lysosomal protein that is also relevant to cancer metastasis [ 140 , 141 ]. The metastatic role of LAMP3 was also further confirmed in head and neck squamous cell carcinoma [ 142 ], oral squamous cell carcinoma (OSCC) [ 143 ], and hepatocellular carcinoma (HCC) [ 144 ] and has recently been reported as a direct target of ATF4 [ 145 ]. Prolonged ERS resulted in irreversible EMT in human peritoneal mesothelial cells (HPMCs), accompanied by activation of the Smad2/3 pathway, nuclear translocation of β -catenin, and expression of Snail [ 146 ].…”

Section: Relationship Between Ers and Emtmentioning

confidence: 99%

Unraveling the Molecular Nexus between GPCRs, ERS, and EMT

Kumari

Reabroi

North

2021

Mediators of Inflammation

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G protein-coupled receptors (GPCRs) represent a large family of transmembrane proteins that transduce an external stimulus into a variety of cellular responses. They play a critical role in various pathological conditions in humans, including cancer, by regulating a number of key processes involved in tumor formation and progression. The epithelial-mesenchymal transition (EMT) is a fundamental process in promoting cancer cell invasion and tumor dissemination leading to metastasis, an often intractable state of the disease. Uncontrolled proliferation and persistent metabolism of cancer cells also induce oxidative stress, hypoxia, and depletion of growth factors and nutrients. These disturbances lead to the accumulation of misfolded proteins in the endoplasmic reticulum (ER) and induce a cellular condition called ER stress (ERS) which is counteracted by activation of the unfolded protein response (UPR). Many GPCRs modulate ERS and UPR signaling via ERS sensors, IRE1α, PERK, and ATF6, to support cancer cell survival and inhibit cell death. By regulating downstream signaling pathways such as NF-κB, MAPK/ERK, PI3K/AKT, TGF-β, and Wnt/β-catenin, GPCRs also upregulate mesenchymal transcription factors including Snail, ZEB, and Twist superfamilies which regulate cell polarity, cytoskeleton remodeling, migration, and invasion. Likewise, ERS-induced UPR upregulates gene transcription and expression of proteins related to EMT enhancing tumor aggressiveness. Though GPCRs are attractive therapeutic targets in cancer biology, much less is known about their roles in regulating ERS and EMT. Here, we will discuss the interplay in GPCR-ERS linked to the EMT process of cancer cells, with a particular focus on oncogenes and molecular signaling pathways.

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Section: Relationship Between Ers and Emtmentioning

confidence: 99%

Unraveling the Molecular Nexus between GPCRs, ERS, and EMT

Kumari

Reabroi

North

2021

Mediators of Inflammation

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“…117 However, the expression of LAMP-3 in non-DC cells has different clinical results, and many reports have shown that the expression of LAMP-3 in non-DC (including EC) is closely related to poor prognosis. [118][119][120][121] This may be related to the activation of its downstream signaling pathway.…”

Section: Tumor-associated Macrophages (Tams)mentioning

confidence: 99%

<p>Esophageal Microenvironment: From Precursor Microenvironment to Premetastatic Niche</p>

Han¹,

Cao²,

Huang³

et al. 2020

CMAR

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Esophageal cancer (EC) is the sixth most deadly cancer, and its incidence is still increasing year by year. Although the researches on the molecular mechanisms of EC have been widely carried out and incremental progress has been made, its overall survival rate is still low. There is cumulative evidence showing that the esophageal microenvironment plays a vital role in the development of EC. In precancerous lesions of the esophagus, high-risk environmental factors can promote the development of precancerous lesions by inducing the production of inflammatory factors and the recruitment of immune cells. In the tumor microenvironment, tumor-promoting cells can inhibit anti-tumor immunity and promote tumor progression through a variety of pathways, such as bone marrow-derived suppressor cells (MDSCs), tumor-associated fibroblasts (CAFs), and regulatory T cells (Tregs). The formation of extracellular hypoxia and acidic microenvironment and the change of extracellular matrix stiffness are also important factors affecting tumor progression and metastasis. Simultaneously, primary tumor-derived cytokines and bone marrow-derived immune cells can also promote the formation of pre-metastasis niche of EC lymph nodes, which are beneficial to EC lymph node metastasis. Further research on the specific mechanism of these processes in the occurrence, development, and metastasis of each EC subtype will support us to grasp the overall pre-cancerous prevention, targeted treatment, and metastatic assessment of EC.

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“…This marker is associated with induction and promotion of tumor migration and invasion (12,13). A significant relationship was seen between LAMP3 expression and lymph node metastasis (6,7). Consequently, LAMP3 expression may be a predictor of cancer patient survival (6).…”

Section: Introductionmentioning

confidence: 99%

“…Lysosome-associated membrane protein 3 (LAMP3, CD208, DC-LAMP), a member of the LAMP protein family, is considered a molecular marker of mature dendritic cells (MDCs) (6). Increased LAMP3 expression is associated with unfavorable prognosis in many cancers including esophageal squamous cell carcinoma (ESCC) (7), gastrointestinal stromal tumor (GIST) (8), breast cancers (9, 10), cervical cancer (11), and head and neck squamous cell carcinomas (6). This marker is associated with induction and promotion of tumor migration and invasion (12,13).…”

Section: Introductionmentioning

confidence: 99%

“…A significant relationship was seen between LAMP3 expression and lymph node metastasis (6,7). Consequently, LAMP3 expression may be a predictor of cancer patient survival (6). Investigations of LAMP3 expression and its association with OSCC patients' clinical features and pathological characteristics are lacking; hence, we aimed to analyze LAMP3 expression in OSCC tissue samples and dysplastic epithelium by quantitative polymerase chain reaction (qPCR).…”

Section: Introductionmentioning

confidence: 99%

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LAMP3 (CD208) Expression in Squamous Cell Carcinoma and Epithelial Dysplasia of the Oral Cavity and Clinicopathological Characteristics of Unfavorable Prognosis

et al. 2021

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Background: This study aimed to evaluate LAMP3 (CD208) gene expression in oral squamous cell carcinoma (OSCC) and dysplastic oral epithelium by quantitative real-time polymerase chain reaction (qPCR) and compare LAMP3 expression in different disease grades and stages. Methods: In this study, 60 OSCC and dysplastic oral epithelium samples were obtained from the Mashhad University of Medical Sciences together with their demographic and clinicopathological documents. LAMP3 expression was measured by qPCR. Results: LAMP3 expression was significantly greater in OSCC than in dysplasia samples (P=0.001), in grade III OSCC than in grades I and II, and also greater in advanced than in early OSCC disease stage (P=0.001). Conclusions:The significantly greater LAMP3 expression in OSCC than in dysplastic epithelium indicates a role for LAMP3 in carcinogenesis in oral mucosa. Our results suggest LAMP3 may be useful as an anticancer target and/or to predict disease pathogenesis in OSCC patient's cells.

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Clinical Significance and Prognostic Value of the Expression of LAMP3 in Oral Squamous Cell Carcinoma

Cited by 9 publications

References 40 publications

Unraveling the Molecular Nexus between GPCRs, ERS, and EMT

Unraveling the Molecular Nexus between GPCRs, ERS, and EMT

<p>Esophageal Microenvironment: From Precursor Microenvironment to Premetastatic Niche</p>

LAMP3 (CD208) Expression in Squamous Cell Carcinoma and Epithelial Dysplasia of the Oral Cavity and Clinicopathological Characteristics of Unfavorable Prognosis

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