Clinical significance of 18F-α-methyl tyrosine PET/CT for the detection of bone marrow invasion in patients with oral squamous cell carcinoma: comparison with 18F-FDG PET/CT and MRI

Abstract

(18)F-FAMT PET/CT was useful and more specific than MRI or (18)F-FDG PET/CT in the detection of bone marrow invasion of OSCC and may contribute to minimize the extent of resection in oral surgery patient.

Effects of Intratumoral Inflammatory Process on 18F-FDG Uptake: Pathologic and Comparative Study with 18F-Fluoro-α-Methyltyrosine PET/CT in Oral Squamous Cell Carcinoma

“…The potential of L-type amino acid transporter 1 as a therapeutic target in oral cancer has been described long before (34,35). We designed 18 F-FAMT as a specific PET radiotracer for L-type amino acid transporter 1 that is overexpressed exclusively in malignant tumors (12) and performed several clinical trials in comparison with 18 F-FDG in oral malignancies (10,14,19). Therefore, analysis of 18 F-FAMT and its corresponding tumor pathologic characteristics is fundamental for the development of a PET imaging-based comprehensive diagnosis of tumor growth.…”

“…With a predetermined pathologically confirmed cutoff SUV of 3.0 for 18 F-FDG and 1.4 for 18 F-FAMT from previous PET study of maxillofacial tumors (19), PET volume computerized-assisted reporting performs autosegmentation to the threshold-defined volumes and automatically calculates MTV and average SUV (10). TLG of 18 F-FDG was calculated by multiplying MTV with the average SUV within that volume.…”

“…18 F-FAMT discriminates malignant tumors from benign lesions in oral malignancies (14,19). Moreover, in OSCC, 18 F-FAMT provides more accurate assessment of bone marrow invasion than 18 F-FDG (10). In this study, we investigated how 18 F-FDG and 18 F-FAMT PET parameters (SUV max , MTV, and TLG or total lesion retention [TLR]) might be affected by intratumoral inflammatory process through a study with tumor inflammation grade obtained from postsurgical specimen pathologic examination.…”

“…To address this, the amino acid-based PET radiotracer 18 F-fluoro-a-methyltyrosine ( 18 F-FAMT), which accumulates exclusively in malignant tumor cells through the L-type amino acid transporter 1, was developed (10)(11)(12). In previous OSCC studies, 18 F-FAMT was better than 18 F-FDG in its correlation with tumor proliferation activity, represented by Ki-67 labeling index (Ki-67 LI) (13,14).…”

Emission Computed Tomography for the Diagnosis of Mandibular Invasion by Head and Neck Cancers: A Systematic Review and Meta-Analysis

“…After retrieving the full text, 17 studies were included (Fig 1). [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] …”