Clinical significance of activated Wnt/β-catenin signaling in apoptosis inhibition of oral cancer

Wang, Yufeng; Cao, Zheng; Liu, Fengjia; Ou, Yuejian

doi:10.1515/biol-2021-0104

Cited by 11 publications

(7 citation statements)

References 33 publications

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“…At the same time, the expression level of anti-apoptotic proteins is enhanced, which promotes vascular formation and re-epithelialization, providing promising strategies for the treatment of stroke diseases [63]. On the other hand, the Wnt signaling pathway can effectively reduce the expression of pro-inflammatory cytokines and play an anti-apoptotic role [111].…”

Section: Brainmentioning

confidence: 99%

Exosomes-Mediated Signaling Pathway: A New Direction for Treatment of Organ Ischemia-Reperfusion Injury

Wang,

Xu,

Yan

et al. 2024

Biomedicines

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Ischemia reperfusion (I/R) is a common pathological process which occurs mostly in organs like the heart, brain, kidney, and lung. The injury caused by I/R gradually becomes one of the main causes of fatal diseases, which is an urgent clinical problem to be solved. Although great progress has been made in therapeutic methods, including surgical, drug, gene therapy, and transplant therapy for I/R injury, the development of effective methods to cure the injury remains a worldwide challenge. In recent years, exosomes have attracted much attention for their important roles in immune response, antigen presentation, cell migration, cell differentiation, and tumor invasion. Meanwhile, exosomes have been shown to have great potential in the treatment of I/R injury in organs. The study of the exosome-mediated signaling pathway can not only help to reveal the mechanism behind exosomes promoting reperfusion injury recovery, but also provide a theoretical basis for the clinical application of exosomes. Here, we review the research progress in utilizing various exosomes from different cell types to promote the healing of I/R injury, focusing on the classical signaling pathways such as PI3K/Akt, NF-κB, Nrf2, PTEN, Wnt, MAPK, toll-like receptor, and AMPK. The results suggest that exosomes regulate these signaling pathways to reduce oxidative stress, regulate immune responses, decrease the expression of inflammatory cytokines, and promote tissue repair, making exosomes a competitive emerging vector for treating I/R damage in organs.

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Section: Brainmentioning

confidence: 99%

Exosomes-Mediated Signaling Pathway: A New Direction for Treatment of Organ Ischemia-Reperfusion Injury

Wang,

Xu,

Yan

et al. 2024

Biomedicines

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“…Interactions with NOTCH signaling highlight a role in cell fate determination and differentiation [139].…”

Section: Wnt/β-catenin Mutations In Relation To Developmental Dynamic...mentioning

confidence: 99%

Mutational Landscape of Oral Squamous Cell Carcinoma Investigated Through the Developmental Dynamics of Oral Squamous Epithelium

Shafi,

Aakash,

Haseeb

et al. 2024

Preprint

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Background: Oral Squamous Cell Carcinoma (OSCC) poses a global health challenge, demanding an in-depth understanding of its mutational landscape. The complex mutational profile underscores the need for targeted therapies. OSCC's impact on crucial functions necessitates precise interventions for improved patient outcomes. This investigation into OSCC's mutational landscape through developmental biology aims to fill critical knowledge gaps, contributing possibly towards future personalized therapies and advancing our approach to this challenging malignancy. Methods: Databases, including PubMed, MEDLINE, Google Scholar, and open access/subscription-based journals were searched for published articles without any date restrictions, to investigate the mutational landscape of OSCC through the lens of developmental dynamics. Based on the criteria mentioned in the methods section, studies were systematically reviewed to investigate OSCC oncogenesis. This study adheres to relevant PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). Results: This study into Oral Squamous Cell Carcinoma (OSCC) reveals a complex genetic landscape marked by mutations in key regulators including TP53, CASP8, CDKN2A, FAT1, PIK3CA, and RYR2. TP53 emerges as a central player, with mutations disrupting its tumor-suppressive functions and influencing developmental processes in OSCC. Dysregulated Notch1 signaling contributes to aberrant cell differentiation and tissue morphogenesis. JAK/STAT and SHH signaling, essential for normal oral epithelial development, exhibit dual dynamics in OSCC, influencing both normal developmental processes and tumorigenesis. Implications for precision medicine arise from the identified genetic alterations, offering potential targets for future therapeutic interventions. Notch1 and TP53 signaling pathways emerge as promising targets, while modulating JAK/STAT and SHH signaling presents challenges and opportunities for new therapeutic strategies. Conclusion: This study reveals genetic complexities and regulatory networks disrupted in OSCC carcinogenesis and also playing key roles in developmental dynamics of oral squamous epithelium. Key genes like TP53 and Notch1, integral to oral epithelial development, undergo dysregulation, influencing OSCC initiation. JAK/STAT and SHH signaling, crucial in normal development, exhibit dual roles, contributing to OSCC progression. This study also points to targeted therapeutic strategies that may emerge in future by investigating OSCC through developmental dynamics. Further research may provide deeper insights into the complex developmental biology, paving the way for enhanced interventions in OSCC.

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“…These factors are essential in genes associated with cell proliferation regulation, survival, and apoptosis, thereby influencing cancer progression [ 37 ]. Furthermore, the canonical WNT/β-catenin pathway plays a significant role in oral cancer, influencing prognosis and treatment response [ 38 , 39 ]. Its aberrant activation can lead to apoptosis resistance and tumorigenesis [ 39 ], while its role in oral carcinogenesis is well-documented [ 40 ].…”

Section: Oxidative Stress and Antioxidant Mechanism In Oral Cancer Re...mentioning

confidence: 99%

Oxidative Stress in the Pathogenesis of Oral Cancer

Ionescu,

Kamal,

Ciobica

et al. 2024

Biomedicines

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Oxidative stress, arising from an imbalance between reactive oxygen species (ROS) and antioxidants, contributes significantly to oral cancer such as oral squamous cell carcinoma (OSCC) initiation, promotion, and progression. ROS, generated both internally and externally, induce cellular damage including DNA mutations and lipid peroxidation, fostering oncogene activation and carcinogenesis. The objective of this review was to cover and analyze the interplay between ROS and antioxidants, influencing the key processes such as cell proliferation, apoptosis, and angiogenesis, shaping the trajectory of OSCC development. Despite the promise of antioxidants to halt cancer progression and mitigate oxidative damage, their therapeutic efficacy remains debated. The conducted literature search highlighted potential biomarkers that indicate levels of oxidative stress, showing promise for the early detection and monitoring of OSCC. Furthermore, melatonin has emerged as a promising adjunct therapy for OSCC, exerting antioxidant and oncostatic effects by modulating tumor-associated neutrophils and inhibiting cancer cell survival and migration. In addition, this review aims to shed light on developing personalized therapeutic strategies for patients with OSCC such as melatonin therapy, which will be discussed. Research is needed to elucidate the underlying mechanisms and clinical implications of oxidative stress modulation in the context of oral cancer.

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Clinical significance of activated Wnt/β-catenin signaling in apoptosis inhibition of oral cancer

Cited by 11 publications

References 33 publications

Exosomes-Mediated Signaling Pathway: A New Direction for Treatment of Organ Ischemia-Reperfusion Injury

Exosomes-Mediated Signaling Pathway: A New Direction for Treatment of Organ Ischemia-Reperfusion Injury

Mutational Landscape of Oral Squamous Cell Carcinoma Investigated Through the Developmental Dynamics of Oral Squamous Epithelium

Oxidative Stress in the Pathogenesis of Oral Cancer

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